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Polymers
Special Issues
Interpolymer Complexes
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Interpolymer Complexes

A special issue of Polymers (ISSN 2073-4360).

Deadline for manuscript submissions: closed (31 August 2018)

Special Issue Editors

Prof. Dr. Vitaliy V. Khutoryanskiy

E-Mail Website
Guest Editor
Reading School of Pharmacy, University of Reading, Reading RG6 6AD, UK
Interests: water-soluble polymers; hydrogels; polymer complexes; drug delivery; mucoadhesion; nanomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Rouslan Moustafine

E-Mail Website
Guest Editor
Department of Pharmaceutical, Analytical and Toxicological Chemistry, Kazan State Medical University, 49 Butlerov Street, 420012 Kazan, Russia
Interests: drug delivery; polymers; polymer complexes; solid dosage forms

Special Issue Information

Dear Colleagues,

Interpolymer complexes are products of interactions between complementary macromolecules in solutions. These may include hydrogen-bonded complexes, complexes between oppositely-charged polyelectrolytes (polyelectrolyte complexes) and complexes between stereo-isomers (stereo-complexes). Additionally, interpolymer complexation is possible at interfaces, e.g., between linear polymers and hydrogels, at solid surfaces (e.g., layer-by-layer deposition), and liquid–liquid interfaces. These complexes could be formed not only by synthetic polymers but also may involve biomacromolecules (e.g., protein–polymer complexes). Complexes between complementary polymers are finding numerous applications, including design of drug delivery systems, coating technologies, microencapsulation, etc.

The aim of this Special Issue is to provide a platform for scientists to share their newest progress in this topic. This Special Issue will publish full research papers, communications, and review articles.

Prof. Vitaliy Khutoryanskiy
Dr. Rouslan Moustafine
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interpolymer complexes
  • polyelectrolyte complexes
  • hydrogen bonding
  • interpolyelectrolyte complexes
  • electrostatic attraction
  • ionic bonds
  • stereo-isomers

Published Papers (2 papers)

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Research

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20 pages, 3456 KiB  
Article
Encapsulation and Ultrasound-Triggered Release of G-Quadruplex DNA in Multilayer Hydrogel Microcapsules
by Aaron Alford, Brenna Tucker, Veronika Kozlovskaya, Jun Chen, Nirzari Gupta, Racquel Caviedes, Jenna Gearhart, David Graves and Eugenia Kharlampieva
Polymers 2018, 10(12), 1342; https://doi.org/10.3390/polym10121342 - 05 Dec 2018
Cited by 25 | Viewed by 4501
Abstract
Nucleic acid therapeutics have the potential to be the most effective disease treatment strategy due to their intrinsic precision and selectivity for coding highly specific biological processes. However, freely administered nucleic acids of any type are quickly destroyed or rendered inert by a [...] Read more.
Nucleic acid therapeutics have the potential to be the most effective disease treatment strategy due to their intrinsic precision and selectivity for coding highly specific biological processes. However, freely administered nucleic acids of any type are quickly destroyed or rendered inert by a host of defense mechanisms in the body. In this work, we address the challenge of using nucleic acids as drugs by preparing stimuli responsive poly(methacrylic acid)/poly(N-vinylpyrrolidone) (PMAA/PVPON)n multilayer hydrogel capsules loaded with ~7 kDa G-quadruplex DNA. The capsules are shown to release their DNA cargo on demand in response to both enzymatic and ultrasound (US)-triggered degradation. The unique structure adopted by the G-quadruplex is essential to its biological function and we show that the controlled release from the microcapsules preserves the basket conformation of the oligonucleotide used in our studies. We also show that the (PMAA/PVPON) multilayer hydrogel capsules can encapsulate and release ~450 kDa double stranded DNA. The encapsulation and release approaches for both oligonucleotides in multilayer hydrogel microcapsules developed here can be applied to create methodologies for new therapeutic strategies involving the controlled delivery of sensitive biomolecules. Our study provides a promising methodology for the design of effective carriers for DNA vaccines and medicines for a wide range of immunotherapies, cancer therapy and/or tissue regeneration therapies in the future. Full article
(This article belongs to the Special Issue Interpolymer Complexes)
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Review

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34 pages, 15799 KiB  
Review
Intra- and Interpolyelectrolyte Complexes of Polyampholytes
by Sarkyt E. Kudaibergenov and Nurxat Nuraje
Polymers 2018, 10(10), 1146; https://doi.org/10.3390/polym10101146 - 14 Oct 2018
Cited by 41 | Viewed by 6767
Abstract
At present, a large amount of research from experimental and theoretical points of view has been done on interpolyelectrolyte complexes formed by electrostatic attractive forces and/or interpolymer complexes stabilized by hydrogen bonds. By contrast, relatively less attention has been given to polymer–polymer complex [...] Read more.
At present, a large amount of research from experimental and theoretical points of view has been done on interpolyelectrolyte complexes formed by electrostatic attractive forces and/or interpolymer complexes stabilized by hydrogen bonds. By contrast, relatively less attention has been given to polymer–polymer complex formation with synthetic polyampholytes (PA). In this review the complexation of polyampholytes with polyelectrolytes (PE) is considered from theoretical and application points of view. Formation of intra- and interpolyelectrolyte complexes of random, regular, block, dendritic polyampholytes are outlined. A separate subsection is devoted to amphoteric behavior of interpolyelectrolyte complexes. The realization of the so-called “isoelectric effect” for interpolyelectrolyte complexes of water-soluble polyampholytes, amphoteric hydrogels and cryogels with respect to surfactants, dye molecules, polyelectrolytes and proteins is demonstrated. Full article
(This article belongs to the Special Issue Interpolymer Complexes)
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