Polymer-Based Fibers and Composites for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Fibers".

Deadline for manuscript submissions: 25 June 2024 | Viewed by 3115

Special Issue Editors

Department of Fiber and Composite Materials, Feng Chia University, Taichung, Taiwan
Interests: atmospheric pressure plasma; green synthesis; green materials; functional composite materials
Department of Chemical and Materials Engineering, National Chin-Yi University of Technology, Taichung, Taiwan
Interests: composite manufacturing; composite mechanics; crystal diffraction; biomaterials
Department of Mechanical Engineering, National Cheng Kung University, Tainan, Taiwan
Interests: nanomaterials; tribology; LED applications; sustainable materials
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Special Issue Information

Dear Colleagues,

Over the course of an accelerating and evolving pandemic, low cost, fast production, and high functionality have become some of the key developments in biomedical applications. Thus, it is of vital importance to focus on research into pure or hybrid polymeric materials in fibrous or composite form with tailored functionality that meet the fundamental requirements of biocompatibility, biodegradability, and microbial growth inhibition.

The objective of this Special Issue is to demonstrate recent interdisciplinary studies in the design, synthesis, fabrication, and characterization of polymer-based fibers and composites for biomedical applications. All original research papers and review articles related to this topic from leading groups around the world are welcome.

Dr. Jason H. C. Yang
Dr. Yi-Jen Huang
Dr. Shih-Chen Shi
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • nanomaterials
  • hydrogels
  • biocompatibility
  • biodegradability
  • hemocompatibility
  • antimicrobial
  • drug delivery system
  • wound dressing
  • medical implants
  • extracellular matrix (ECM)
  • biocoatings
  • nanoparticles

Published Papers (2 papers)

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Research

17 pages, 4465 KiB  
Article
Polycaprolactone Nanofibers Functionalized by Fibronectin/Gentamicin and Implanted Silver for Enhanced Antibacterial Properties, Cell Adhesion, and Proliferation
by Elizaveta S. Permyakova, Anastasiya O. Solovieva, Natalia Sitnikova, Philipp V. Kiryukhantsev-Korneev, Magzhan K. Kutzhanov, Alexander N. Sheveyko, Sergey G. Ignatov, Pavel V. Slukin, Dmitry V. Shtansky and Anton M. Manakhov
Polymers 2024, 16(2), 261; https://doi.org/10.3390/polym16020261 - 17 Jan 2024
Viewed by 692
Abstract
Novel nanomaterials used for wound healing should have many beneficial properties, including high biological and antibacterial activity. Immobilization of proteins can stimulate cell migration and viability, and implanted Ag ions provide an antimicrobial effect. However, the ion implantation method, often used to introduce [...] Read more.
Novel nanomaterials used for wound healing should have many beneficial properties, including high biological and antibacterial activity. Immobilization of proteins can stimulate cell migration and viability, and implanted Ag ions provide an antimicrobial effect. However, the ion implantation method, often used to introduce a bactericidal element into the surface, can lead to the degradation of vital proteins. To analyze the surface structure of nanofibers coated with a layer of plasma COOH polymer, fibronectin/gentamicin, and implanted with Ag ions, a new X-ray photoelectron spectroscopy (XPS) fitting method is used for the first time, allowing for a quantitative assessment of surface biomolecules. The results demonstrated noticeable changes in the composition of fibronectin- and gentamicin-modified nanofibers upon the introduction of Ag ions. Approximately 60% of the surface chemistry has changed, mainly due to an increase in hydrocarbon content and the introduction of up to 0.3 at.% Ag. Despite the significant degradation of fibronectin molecules, the biological activity of Ag-implanted nanofibers remained high, which is explained by the positive effect of Ag ions inducing the generation of reactive oxygen species. The PCL nanofibers with immobilized gentamicin and implanted silver ions exhibited very significant antipathogen activity to a wide range of Gram-positive and Gram-negative strains. Thus, the results of this work not only make a significant contribution to the development of new hybrid fiber materials for wound dressings but also demonstrate the capabilities of a new XPS fitting methodology for quantitative analysis of surface-related proteins and antibiotics. Full article
(This article belongs to the Special Issue Polymer-Based Fibers and Composites for Biomedical Applications)
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20 pages, 5857 KiB  
Article
Poly(vinyl alcohol)/Silk Fibroin/Ag-NPs Composite Nanofibers as a Substrate for MG-63 Cells’ Growth
by Monica L. Mejía Suaza, Jennifer C. Leos Rivera, Maria C. Rodríguez Padilla, Maria E. Moncada Acevedo, Claudia P. Ossa Orozco and Diana G. Zarate Triviño
Polymers 2023, 15(8), 1838; https://doi.org/10.3390/polym15081838 - 11 Apr 2023
Cited by 2 | Viewed by 1623
Abstract
Nanofiber scaffolds of polyvinyl alcohol, silk fibroin from Bombyx mori cocoons, and silver nanoparticles were developed as a substrate for MG-63 growth. The fiber morphology, mechanical properties, thermal degradation, chemical composition, and water contact angle were investigated. In vitro tests were performed by [...] Read more.
Nanofiber scaffolds of polyvinyl alcohol, silk fibroin from Bombyx mori cocoons, and silver nanoparticles were developed as a substrate for MG-63 growth. The fiber morphology, mechanical properties, thermal degradation, chemical composition, and water contact angle were investigated. In vitro tests were performed by the cell viability MTS test of MG-63 cells on electrospun PVA scaffolds, mineralization was analyzed by alizarin red, and the alkaline phosphatase (ALP) assay was evaluated. At higher PVA concentrations, Young’s modulus (E) increased. The addition of fibroin and silver nanoparticles improved the thermal stability of PVA scaffolds. FTIR spectra indicated characteristic absorption peaks related to the chemical structures of PVA, fibroin, and Ag-NPs, demonstrating good interactions between them. The contact angle of the PVA scaffolds decreased with the incorporation of fibroin and showed hydrophilic characteristics. In all concentrations, MG-63 cells on PVA/fibroin/Ag-NPs scaffolds had higher cell viability than PVA pristine. On day ten of culture, PVA18/SF/Ag-NPs showed the highest mineralization, observed by the alizarin red test. PVA10/SF/Ag-NPs presented the highest alkaline phosphatase activity after an incubation time of 37 h. The achievements indicate the potential of the nanofibers of PVA18/SF/Ag-NPs as a possible substitute for bone tissue engineering (BTE). Full article
(This article belongs to the Special Issue Polymer-Based Fibers and Composites for Biomedical Applications)
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