Study in Chitosan and Crosslinked Chitosan Nanoparticles

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 2457

Special Issue Editors

Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro 76010, Mexico
Interests: nanoparticles; enzyme immobilization; biorefinery; nanobiocatalyst; hydrolytic enzymes; magnetic composite
Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas s/n, Col. Las Campanas, Queretaro 76010, Mexico
Interests: active edible films; essential oil; mesoporous silica nanoparticles; nanocellulose; biodegradability; edible coating; chitosan; food preservation
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Special Issue Information

Dear Colleagues,

Chitosan is a biodegradable polymer derived from chitin, which is found in the exoskeletons of crustaceans. It has a wide range of applications, including as a drug delivery system, wound dressing, and food preservative. Crosslinked chitosan nanoparticles are chitosan nanoparticles with a large surface area that have been treated with a crosslinking agent to increase their stability and durability. Crosslinking can also improve the mechanical properties of the nanoparticles, making them more resistant to degradation by enzymes or pH changes. This increased stability leads to crosslinked chitosan nanoparticles having many potential applications in various industries due to their biocompatibility, biodegradability, and versatility.

Dr. Aldo Amaro-Reyes
Prof. Dr. Carlos Regalado-González
Guest Editors

Manuscript Submission Information

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Keywords

  • chitosan
  • crosslinking
  • nanoparticles
  • tissue engineering
  • enzyme immobilization
  • targeted drug delivery
  • genipin
  • glutaraldehyde
  • tripolyphosphate
  • polymer coating
  • nanobiocatalyst

Published Papers (1 paper)

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Review

28 pages, 4110 KiB  
Review
Advancements in Chitosan-Based Nanoparticles for Pulmonary Drug Delivery
by Thiago Medeiros Zacaron, Mariana Leite Simões e Silva, Mirsiane Pascoal Costa, Dominique Mesquita e Silva, Allana Carvalho Silva, Ana Carolina Morais Apolônio, Rodrigo Luiz Fabri, Frederico Pittella, Helvécio Vinícius Antunes Rocha and Guilherme Diniz Tavares
Polymers 2023, 15(18), 3849; https://doi.org/10.3390/polym15183849 - 21 Sep 2023
Cited by 3 | Viewed by 2200
Abstract
The evolution of respiratory diseases represents a considerable public health challenge, as they are among the leading causes of death worldwide. In this sense, in addition to the high prevalence of diseases such as asthma, chronic obstructive pulmonary disease, pneumonia, cystic fibrosis, and [...] Read more.
The evolution of respiratory diseases represents a considerable public health challenge, as they are among the leading causes of death worldwide. In this sense, in addition to the high prevalence of diseases such as asthma, chronic obstructive pulmonary disease, pneumonia, cystic fibrosis, and lung cancer, emerging respiratory diseases, particularly those caused by members of the coronavirus family, have contributed to a significant number of deaths on a global scale over the last two decades. Therefore, several studies have been conducted to optimize the efficacy of treatments against these diseases, focusing on pulmonary drug delivery using nanomedicine. Thus, the development of nanocarriers has emerged as a promising alternative to overcome the limitations of conventional therapy, by increasing drug bioavailability at the target site and reducing unwanted side effects. In this context, nanoparticles composed of chitosan (CS) show advantages over other nanocarriers because chitosan possesses intrinsic biological properties, such as anti-inflammatory, antimicrobial, and mucoadhesive capacity. Moreover, CS nanoparticles have the potential to enhance drug stability, prolong the duration of action, improve drug targeting, control drug release, optimize dissolution of poorly soluble drugs, and increase cell membrane permeability of hydrophobic drugs. These properties could optimize the performance of the drug after its pulmonary administration. Therefore, this review aims to discuss the potential of chitosan nanoparticles for pulmonary drug delivery, highlighting how their biological properties can improve the treatment of pulmonary diseases, including their synergistic action with the encapsulated drug. Full article
(This article belongs to the Special Issue Study in Chitosan and Crosslinked Chitosan Nanoparticles)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Stabilization of Active Principles in Chitosan Nanoparticles
Authors: Alberto Balfagón Costa et al.
Affiliation: Department of Chemical Engineering and Materials Science, Institut Químic de Sarrià, Universitat Ramón Llull, 08017 Barcelona, Spain

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