Chitosan in Drug Delivery

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 1392

Special Issue Editors


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Guest Editor
Romania Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa"—Iași, 700115 Iasi, Romania
Interests: organic synthesis; chitosan microparticles and nanoparticles; antioxidant activity; diabetes mellitus type 2; drug delivery systems; drug loading; release profile
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, Romania
Interests: synthesis; 13C-NMR; 1H-NMR; synthetic chemistry; synthetic organic chemistry; heterocyclic chemistry; organic chemistry synthesis; IR; medicinal and pharmaceutical chemistry
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, Romania
Interests: anti-inflammatory agents; DPPH; antioxidant activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Drug delivery systems (DDSs) hold an important position in the pharmaceutical field in order to improve the pharmacological properties of free conventional drugs. Chitosan, either alone or as a composite, due to its numerous beneficial properties is extensively researched as a drug carrier for various routes of administration. Its properties are closely related to the type of manufactured carrier (hydrogels, films, membranes, beads, porous foams, micro- and nanoparticles, in situ gels, sponges, nanofibers, etc.). Therefore, chemists, bioengineers, physicists, and materials science specialists targeting the development of new DDSs, are welcome to share their results by publishing in this Special Issue.

Topics of interest for this Special Issue include, yet are not limited to, the following:

  • Design, development, and characterization of chitosan DDSs;
  • Applications of these DDSs and their in vitro and in vivo evaluation;
  • Other topics which highlight the importance of using chitosan in the development of new DDSs to support targeted therapy. 

This Special Issue is addressed to a large number of readers in the materials science field; we encourage the submission of articles for review and later publication.

Dr. Florentina Lupascu
Dr. Maria Apotrosoaei
Dr. Ioana Mirela Vasincu
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chitosan
  • drug delivery systems
  • hydrogels
  • films
  • nanofibers
  • microparticles
  • nanoparticles
  • polymeric materials
  • target drug carriers
  • drugs
  • polymer carriers
  • drug loading

Published Papers (1 paper)

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Research

14 pages, 8380 KiB  
Article
pH-Responsive Chitosan-Doped ZnO Hybrid Hydrogels for the Encapsulation of Bioactive Compounds in Aquaculture
by Samuel Sánchez-Serrano, Daniela J. González-Méndez, José A. Olivas-Valdez, Natalie Millán-Aguiñaga, Viridiana Evangelista, Oscar E. Contreras and Marlene N. Cardoza-Contreras
Polymers 2023, 15(20), 4105; https://doi.org/10.3390/polym15204105 - 16 Oct 2023
Viewed by 903
Abstract
In this study, we synthesized and characterized pH-responsive Chitosan–AgCl-doped ZnO hybrid hydrogels and evaluated their potential for loading aquaculture bioactive compounds, and assessed their antimicrobial properties against a threatening pathogen associated with disease across a broad spectrum of warm water fish and invertebrates. [...] Read more.
In this study, we synthesized and characterized pH-responsive Chitosan–AgCl-doped ZnO hybrid hydrogels and evaluated their potential for loading aquaculture bioactive compounds, and assessed their antimicrobial properties against a threatening pathogen associated with disease across a broad spectrum of warm water fish and invertebrates. Hydrogel characterization consisted of assessing morphology via SEM, composition via EDS, hydrogels’ network components interactions via FT-IR and pH response through swelling behavior determinations. The swelling characterization of the synthesized hydrogels demonstrated a pH-responsive behavior, showing that low pH values caused the hydrogel polymeric network to expand and capture more of the aqueous solution. These characteristics make the synthesized hydrogels suitable for the encapsulation and controlled release of drugs and bioactive compounds in aquaculture. Chitosan_ZnO hybrid hydrogels showed great antimicrobial activity against Vibrio harveyi, even better than that of loaded PB hydrogels. Here, we provide evidence for the potential capacity of Chitosan_ZnO hybrid hydrogels for the preventive and curative treatment of diseases that impact aquaculture animal health and prevent drug resistance by bacteria. Full article
(This article belongs to the Special Issue Chitosan in Drug Delivery)
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