Sustainability Functional Biopolymers for Future Precision Medicine: Processing and Translational Issues

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 2244

Special Issue Editors

Centre for Tissue Engineering and Regenerative Medicine (CTERM), Faculty of Medicine, 12th Floor Clinical Block, UKM Medical Centre, Jalan Yaacob Latiff, Cheras 56000, Kuala Lumpur, Malaysia
Interests: biomaterials; drug delivery system; skin wound healing; tissue engineering and regenerative medicine; cell delivery system; multifunctional smart materials; acellular tissue substitute; nanomaterials technology
Special Issues, Collections and Topics in MDPI journals
Department of Industrial Engineering, BIOtech Research Center, University of Trento, Via Sommarive 9, 38123 Trento, Italy
Interests: scaffolds design; regenerative medicine; nature-derived matrices; polymers functionalization; cells; tissue engineering; stem cell culture; cell culture; biocompatibility evaluations; bioink design; drug release systems; 3D in vitro models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Precision medicine is a future essential advanced shifting era in clinical practice to construct suitable treatments that are based on an individual or subsets of patients. Functional biopolymer development faces a challenge due to the limitations of a “one-size-fits-all” approach to medicine intentions. Recently, a new concept of bioconvergence approaches has been introduced in regenerative medicine involving expertise from various fields, primarily synergistic life sciences, technology, and computerized systems. For this strategy to succeed, sustainable functional biopolymers must play a major role in future precision/personalized medicine. Certain issues should be addressed, especially in terms of the selection of compatible natural polymers, extraction, characterization, cell interaction, efficiency in preclinical models, mass production, and translational issues, mainly in clinical trial stages. This Special Issue will serve as a platform to gather new biopolymers, technologies, and perspectives from experts globally regarding the sustainability of authentic functional biopolymers.

Prof. Dr. Mh Busra Fauzi
Prof. Dr. Antonella Motta
Guest Editors

Manuscript Submission Information

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Published Papers (1 paper)

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Review

36 pages, 2175 KiB  
Review
Recent Approaches to the Modification of Collagen Biomatrix as a Corneal Biomatrix and Its Cellular Interaction
by Nur Amalia Ra’oh, Rohaina Che Man, Mh Busra Fauzi, Norzana Abd Ghafar, Muhamad Ramdzan Buyong, Ng Min Hwei and Wan Haslina Wan Abdul Halim
Polymers 2023, 15(7), 1766; https://doi.org/10.3390/polym15071766 - 01 Apr 2023
Viewed by 1865
Abstract
Over the last several decades, numerous modifications and advancements have been made to design the optimal corneal biomatrix for corneal epithelial cell (CECs) or limbal epithelial stem cell (LESC) carriers. However, researchers have yet to discover the ideal optimization strategies for corneal biomatrix [...] Read more.
Over the last several decades, numerous modifications and advancements have been made to design the optimal corneal biomatrix for corneal epithelial cell (CECs) or limbal epithelial stem cell (LESC) carriers. However, researchers have yet to discover the ideal optimization strategies for corneal biomatrix design and its effects on cultured CECs or LESCs. This review discusses and summarizes recent optimization strategies for developing an ideal collagen biomatrix and its interactions with CECs and LESCs. Using PRISMA guidelines, articles published from June 2012 to June 2022 were systematically searched using Web of Science (WoS), Scopus, PubMed, Wiley, and EBSCOhost databases. The literature search identified 444 potential relevant published articles, with 29 relevant articles selected based on inclusion and exclusion criteria following screening and appraising processes. Physicochemical and biocompatibility (in vitro and in vivo) characterization methods are highlighted, which are inconsistent throughout various studies. Despite the variability in the methodology approach, it is postulated that the modification of the collagen biomatrix improves its mechanical and biocompatibility properties toward CECs and LESCs. All findings are discussed in this review, which provides a general view of recent trends in this field. Full article
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