Polymer-Based Biomaterials for Tissue Engineering Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1203

Special Issue Editors

Guangxi Key Laboratory of Manufacturing System and Advanced Manufacturing Technology, School of Mechanical Engineering, Guangxi University, Nanning 530004, China
Interests: polymer scaffolds; additive manufacturing; tissue engineering; biomaterials; nanocomposites; functional materials; biological properties; mechanical properties; degradation properties; drug release
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Guangxi Key Laboratory of Manufacturing System and Advanced Manufacturing Technology, School of Mechanical Engineering, Guangxi University, Nanning 530004, China
Interests: microfluidic and biochips; MEMS (microelectro-mechanical systems); microsensors; micro-nano machining; precision manufacturing; biological manufacturing; biomedical instruments; environmental monitorin
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College of Mechanical and Electrical Engineering, Central South University, Changsha, China
Interests: 3D/4D printing; biofabrication; shape memory; bone scaffold; biomaterials; function materials; polymers; nanocomposites
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Mechanical Engineering, Guangxi University, Nanning, China
Interests: intelligent manufacturing; additive manufacturing; 3D/4D printing; laser manufacturing; biomanufacturing; flexible electronics; bionic robot; intelligent monitoring and control
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Special Issue Information

Dear Colleagues,

Tissue engineering is an attractive interdisciplinary field aiming to develop functional biological substitutes to restore or improve tissue function by combining various scaffolds with cells. In recent years, polymer-based biomaterials have played a pivotal role in tissue engineering and have attracted significant attention.

This Special Issue aims to encompass the development of state-of-the-art polymeric biomaterials and cutting-edge applications of polymer biomaterials in the field of tissue engineering. The topics include, but are not limited to, the following:

  • Tissue engineering;
  • Polymeric biomaterials;
  • 3D/4D printing;
  • Bioprinting;
  • Cell printing;
  • Organ and organ-like structure printing;
  • Additive manufacturing of biomimetic materials and structures;
  • Design and additive manufacturing of tissue-engineered bone, blood vessels, and skin;
  • Additive manufacturing of pharmaceuticals and drug-loaded implants.

We welcome original research papers and reviews addressing new materials, processes, performance evaluations, and practical applications to drive continuous innovation in this field.

Dr. Wang Guo
Prof. Dr. Hui You
Prof. Dr. Pei Feng
Prof. Dr. Yu Long
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer-based biomaterials
  • tissue engineering
  • additive manufacturing
  • 3D printing
  • 4D printing
  • bioprinting
  • cell printing
  • organ and organoid printing
  • biomimetic materials and structures

Published Papers (2 papers)

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Research

24 pages, 17897 KiB  
Article
Researching on the Effect of Input Parameters on the Quality and Manufacturability of 3D-Printed Cellular Samples from Nylon 12 CF in Synergy with Testing Their Behavior in Bending
by Martin Koroľ, Jozef Török, Peter Pavol Monka, Petr Baron, Beata Mrugalska and Katarina Monkova
Polymers 2024, 16(10), 1429; https://doi.org/10.3390/polym16101429 - 17 May 2024
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Abstract
The study of cellular structures and their properties represents big potential for their future applications in real practice. The article aims to study the effect of input parameters on the quality and manufacturability of cellular samples 3D-printed from Nylon 12 CF in synergy [...] Read more.
The study of cellular structures and their properties represents big potential for their future applications in real practice. The article aims to study the effect of input parameters on the quality and manufacturability of cellular samples 3D-printed from Nylon 12 CF in synergy with testing their bending behavior. Three types of structures (Schwarz Diamond, Shoen Gyroid, and Schwarz Primitive) were selected for investigation that were made via the fused deposition modeling technique. As part of the research focused on the settings of input parameters in terms of the quality and manufacturability of the samples, input parameters such as volume fraction, temperature of the working space, filament feeding method and positioning of the sample on the printing pad were specified for the combination of the used material and 3D printer. During the experimental investigation of the bending properties of the samples, a three-point bending test was performed. The dependences of force on deflection were mathematically described and the amount of absorbed energy and ductility were evaluated. The results show that among the investigated structures, the Schwarz Diamond structure appears to be the most suitable for bending stress applications. Full article
(This article belongs to the Special Issue Polymer-Based Biomaterials for Tissue Engineering Applications)
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32 pages, 14592 KiB  
Article
The Impacts of the Sterilization Method and the Electrospinning Conditions of Nanofibrous Biodegradable Layers on Their Degradation and Hemocompatibility Behavior
by Kristyna Havlickova, Eva Kuzelova Kostakova, Maxim Lisnenko, Sarka Hauzerova, Martin Stuchlik, Stanislava Vrchovecka, Lucie Vistejnova, Jiri Molacek, David Lukas, Renata Prochazkova, Jana Horakova, Sarka Jakubkova, Bohdana Heczkova and Vera Jencova
Polymers 2024, 16(8), 1029; https://doi.org/10.3390/polym16081029 - 9 Apr 2024
Cited by 1 | Viewed by 507
Abstract
The use of electrospun polymeric biodegradable materials for medical applications is becoming increasingly widespread. One of the most important parameters regarding the functionality of nanofiber scaffolds during implantation and the subsequent regeneration of damaged tissues concerns their stability and degradation behavior, both of [...] Read more.
The use of electrospun polymeric biodegradable materials for medical applications is becoming increasingly widespread. One of the most important parameters regarding the functionality of nanofiber scaffolds during implantation and the subsequent regeneration of damaged tissues concerns their stability and degradation behavior, both of which are influenced by a wide range of factors (the properties of the polymer and the polymer solution, the technological processing approach, the sterilization method, etc.). This study monitored the degradation of nanofibrous materials fabricated from degradable polyesters as a result of the sterilization method applied (ethylene oxide and gamma irradiation) and the solvent system used to prepare the spun polymer solution. Aliphatic polyesters PCL and PLCL were chosen for this study and selected with respect to the applicability and handling in the surgical setting of these nanofibrous materials for vascular bandaging. The results revealed that the choice of solvent system exerts a significant impact on degradation during sterilization, especially at higher gamma irradiation values. The subsequent enzyme-catalyzed degradation of the materials following sterilization indicated that the choice of the sterilization method influenced the degradation behavior of the materials. Whereas wave-like degradation was evident concerning ethylene oxide sterilization, no such behavior was observed following gamma-irradiation sterilization. With concern for some of the tested materials, the results also indicated the potential for influencing the development of degradation within the bulk versus degradation from the surface of the material. Both the sterilization method and the choice of the spinning solvent system were found to impact degradation, which was observed to be most accelerated in the case of PLCL (L-lactide-co-caprolactone copolymer) electrospun from organic acids and subsequently sterilized using gamma irradiation. Since we planned to use these materials in cardiovascular applications, it was decided that their hemocompatibility would also be tested. The results of these tests revealed that changes in the structures of the materials initiated by sterilization may exert thrombogenic and anticoagulant impacts. Moreover, the microscopic analysis suggested that the solvent system used in the preparation of the materials potentially affects the behavior of erythrocytes; however, no indication of the occurrence of hemolysis was detected. Full article
(This article belongs to the Special Issue Polymer-Based Biomaterials for Tissue Engineering Applications)
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