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Polymers
Special Issues
Responsive Biomaterials for Applications in Disease Diagnosis and Drug Delivery
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Responsive Biomaterials for Applications in Disease Diagnosis and Drug Delivery

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2881

Special Issue Editor

Prof. Dr. Chen Xie

E-Mail Website
Guest Editor
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, China
Interests: optical imaging and cancer therapy; organic conjugated materials for tumor imaging and treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Responsive biomaterials are commonly regarded as biomaterials whose properties may change with exposure to external stimuli, such as heat, light, biomarkers and pH. Such a feature makes them suitable for disease diagnosis and drug delivery. Disease sites usually have unique features compared with normal tissues, including the overexpression of specific biomarkers, or abnormal pH or oxygen levels. Well-designed responsive biomaterials may respond to these dysfunctions and further lead to the release of drugs or generation of signals, making both the diagnosis and therapy more precise. In the past decades, researchers have developed a variety of responsive biomaterials for precise diagnosis and medicine, which show great promise. The purpose of this Special Issue is to collect these studies and present them to a wider academic community to further promote the development of responsive biomaterials.

Prof. Dr. Chen Xie
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterial
  • stimuli-responsive
  • disease diagnosis
  • drug delivery

Published Papers (2 papers)

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Research

11 pages, 11534 KiB  
Article
Oligomerization Strategy of D-A-Type Conjugated Molecules for Improved NIR-II Fluorescence Imaging
by Tongqing Zou, Yu Liu, Xinyue Zhang, Lu Chen, Qinqin Xu, Yancheng Ding, Ping Li, Chen Xie, Chao Yin and Quli Fan
Polymers 2023, 15(16), 3451; https://doi.org/10.3390/polym15163451 - 18 Aug 2023
Cited by 1 | Viewed by 1024
Abstract
Fluorescence imaging (FI) in the second near-infrared (NIR-II) window has emerged as a promising imaging method for cancer diagnosis because of its superior properties such as deep penetration depth and high signal-to-background ratio. Despite the superiorities of organic conjugated nanomaterials for NIR-II FI, [...] Read more.
Fluorescence imaging (FI) in the second near-infrared (NIR-II) window has emerged as a promising imaging method for cancer diagnosis because of its superior properties such as deep penetration depth and high signal-to-background ratio. Despite the superiorities of organic conjugated nanomaterials for NIR-II FI, the issues of low fluorescence quantum yield, weak metabolic capability, undefined molecular structure for conjugated polymers, weak light-harvesting ability, short emission wavelength, and high synthetic complexity for conjugated small molecules still remain to be concerned. We herein propose an oligomerization strategy by facilely adjusting the oligomerization time to balance the advantages and disadvantages between conjugated polymers and small molecules, obtaining the candidate (CO1, oligomerization time: 1 min) with the optimal NIR-II optical performance. Then the CO1 is further prepared into water-dispersed nanoparticles (CON1) via a nanoprecipitation approach. By virtue of the suitable size, excellent NIR-II optical properties, low toxicity, and strong cell-labeling ability, the CON1 is successfully employed for in vivo NIR-II imaging, permitting the real-time visualization of blood vascular system and tumors with high sensitivity and resolution. This work thus not only provides a personalized organic conjugated nano-agent for NIR-II FI, but also highlights the molecular strategy for the development of organic conjugated systems with optimal performance for bio-imaging. Full article
(This article belongs to the Special Issue Responsive Biomaterials for Applications in Disease Diagnosis and Drug Delivery)
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13 pages, 4877 KiB  
Article
Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor
by Dashan Qi, Haowei Zhu, Yingjie Kong and Qingming Shen
Polymers 2022, 14(24), 5547; https://doi.org/10.3390/polym14245547 - 18 Dec 2022
Cited by 7 | Viewed by 1512
Abstract
Traditional hydrogels have drawbacks such as surgical implantation, large wound surfaces, and uncontrollable drug release during tumor treatment. In this paper, targeted nanomedicine has been combined with injectable hydrogel for photothermal–chemotherapy combination therapy. First, targeted nanomedicine (ICG—MTX) was fabricated by combining near-infrared (NIR) [...] Read more.
Traditional hydrogels have drawbacks such as surgical implantation, large wound surfaces, and uncontrollable drug release during tumor treatment. In this paper, targeted nanomedicine has been combined with injectable hydrogel for photothermal–chemotherapy combination therapy. First, targeted nanomedicine (ICG—MTX) was fabricated by combining near-infrared (NIR) photothermal reagents (ICG) and chemotherapy drugs (MTX). The ICG—MTX was then mixed with the hydrogel precursor and radical initiator to obtain an injectable hydrogel precursor solution. Under the irradiation of NIR light, the precursor solution could release alkyl radicals, which promote the transition of the precursor solution from a liquid to a colloidal state. As a result, the nanomedicine could effectively remain at the site of the tumor and continue to be released from the hydrogel. Due to the targeted nature of MTX, the released ICG—MTX could target tumor cells and improve the accuracy of photothermal–chemo combination therapy. The results indicated that the injectable nanomedicine–hydrogel system has a favorable therapeutic effect on tumors. Full article
(This article belongs to the Special Issue Responsive Biomaterials for Applications in Disease Diagnosis and Drug Delivery)
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