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Anti-Inflammatory Bioactivities in Plant Extracts
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Anti-Inflammatory Bioactivities in Plant Extracts

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 14779

Special Issue Editors

Dr. Yoana Dimitrova Kiselova-Kaneva

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Guest Editor
Department of Biochemistry Molecular Medicine and Nutrigenomics, Medical University “Prof. D-r Paraskev Stoyanov”, Varna, Bulgaria
Interests: medicinal plants; bioactive compounds of plant origin; polyphenols; in vitro and in vivo antioxidant; anti-inflammatory and immunomodulatory properties of plant derived products
Special Issues, Collections and Topics in MDPI journals
Dr. Ilian Badjakov

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Guest Editor
Agrobiotechnology, AgroBioInstitute, Agricultural Academy, 1164 Sofia, Bulgaria
Interests: natural products; bioactive compounds; GC-MS; LC-ESI-MS/MS; biotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Ivayla Dincheva

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Guest Editor
Agrobiotechnologies, AgroBioInstitute, Agricultural Academy, 1164 Sofia, Bulgaria
Interests: metabolomics; natural product chemistry; bioactive compounds; GC-MS; LC-ESI-MS/MS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Considering the vast diversity among the plant species and the large number of identified compounds from plant origin it is clear that their healing potential is huge and still insufficiently studied. Studies on the links between the existing empirical data from folk medicine and the mechanisms of curative effects are being supported by the evolving and growing potential of modern medico-biological research and clinical investigations. Inflammation is associated with a vast variety of acute and chronic pathological conditions and diseases. On the other hand, synthetic anti-inflammatory drugs may have unwanted and adverse effects. In this regard, the search for new and safe preparations from plant origin provides an alternative and/or complementary tool for the control of inflammation processes. Revealing the molecular effects of medicinal plants and their biologically active components and identifying new molecular targets of action is essential for the development of nutrition, biotechnology and pharmaceutical sciences.

This Special Issue will focus on the phytochemical identification of plant constituents with anti-inflammatory potential. Results from in in silico, in vitro, including in cell culture models, in vivo experiments and human intervention studies are also welcomed. Original data and review articles with phytochemical analyses and experiments with pure compounds, different types of extracts and fractions revealing the anti-inflammatory potentials of the plants will be accepted. 

Dr. Yoana Dimitrova Kiselova-Kaneva
Dr. Ilian Badjakov
Dr. Ivayla N. Dincheva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal plants
  • phytochemical composition
  • anti-inflammatory properties

Published Papers (7 papers)

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Research

13 pages, 1966 KiB  
Article
Anti-Inflammatory Effect of Ebractenoid F, a Major Active Compound of Euphorbia ebracteolata Hayata, through Inhibition of Nuclear Factor-κB Activation
by Jaemoo Chun, Sang Yeon Mah and Yeong Shik Kim
Plants 2023, 12(15), 2845; https://doi.org/10.3390/plants12152845 - 01 Aug 2023
Cited by 1 | Viewed by 883
Abstract
Euphorbia ebracteolata Hayata (Euphorbiaceae family) is a perennial plant that is widely distributed in Korea, Japan, and China. Its roots contain bioactive diterpenes that have anti-inflammatory properties. However, the anti-inflammatory mechanisms are not yet fully understood. This study aimed to identify the most [...] Read more.
Euphorbia ebracteolata Hayata (Euphorbiaceae family) is a perennial plant that is widely distributed in Korea, Japan, and China. Its roots contain bioactive diterpenes that have anti-inflammatory properties. However, the anti-inflammatory mechanisms are not yet fully understood. This study aimed to identify the most active anti-inflammatory compound from the roots of E. ebracteolata Hayata, using bioassay-guided fractionation and a combinative method of high-speed countercurrent chromatography (HSCCC) and preparative high-performance liquid chromatography (HPLC). Then, we investigated its anti-inflammatory mechanism in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Ebractenoid F was identified as the most potent bioactive compound of E. ebracteolata Hayata. Ebractenoid F significantly decreased nitric oxide (NO) production and nuclear factor-κB (NF-κB) activation induced by LPS in RAW 264.7 macrophages. Moreover, ebractenoid F decreased the degradation of inhibitory κB-α, the nuclear translocation of the p65 and p50 subunits of NF-κB, and the expression of NF-κB downstream genes. Furthermore, ebractenoid F inhibited the phosphorylation of Akt and mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in LPS-stimulated RAW 264.7 cells. In conclusion, ebractenoid F exerts the most potent anti-inflammatory effect by suppressing NF-κB-mediated NO production in LPS-stimulated RAW 264.7 cells. Ebractenoid F may be a useful therapeutic compound for the prevention or treatment of inflammation-associated diseases. Full article
(This article belongs to the Special Issue Anti-Inflammatory Bioactivities in Plant Extracts)
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19 pages, 2437 KiB  
Article
Anti-Inflammatory Activities of Arnica montana Planta Tota versus Flower Extracts: Analytical, In Vitro and In Vivo Mouse Paw Oedema Model Studies
by Johann Röhrl, Maria-Riera Piqué-Borràs, Manuela Jaklin, Markus Werner, Oliver Werz, Heinke Josef, Hubert Hölz, Aldo Ammendola and Gerald Künstle
Plants 2023, 12(6), 1348; https://doi.org/10.3390/plants12061348 - 16 Mar 2023
Cited by 5 | Viewed by 2515
Abstract
Arnica montana is well known for its anti-inflammatory properties. While the anti-inflammatory activity of Arnica flowers (Arnicae flos) has been extensively studied, that of the whole plant (Arnicae planta tota) is less characterized. We compared the ability of Arnicae planta tota and Arnicae [...] Read more.
Arnica montana is well known for its anti-inflammatory properties. While the anti-inflammatory activity of Arnica flowers (Arnicae flos) has been extensively studied, that of the whole plant (Arnicae planta tota) is less characterized. We compared the ability of Arnicae planta tota and Arnicae flos extracts to inhibit the pro-inflammatory NF-κB—eicosanoid pathway, using several in vitro and in vivo assays. We showed that Arnicae planta tota inhibited NF-κB reporter activation, with an IC50 of 15.4 μg/mL (vs. 52.5 μg/mL for Arnicae flos). Arnicae planta tota also inhibited LPS-induced expression of ALOX5 and PTGS2 genes in human differentiated macrophages. ALOX5 and PTGS2 encode the 5-lipoxygenase (5-LO) and cyclooxygenase-2 (COX-2) enzymes that initialize the conversion of arachidonic acid into leukotrienes and prostaglandins, respectively. Arnicae planta tota inhibited 5-LO and COX-2 enzymatic activity in vitro and in human primary peripheral blood cells, with lower IC50 compared to Arnicae flos. Finally, Arnicae planta tota applied topically reduced carrageenan-induced mouse paw oedema more efficiently than Arnicae flos. Altogether, Arnicae planta tota displayed a superior anti-inflammatory activity compared to Arnicae flos, suggesting that Arnicae-planta-tota-containing products might be more effective in alleviating the manifestations of acute inflammation than those based on Arnicae flos alone. Full article
(This article belongs to the Special Issue Anti-Inflammatory Bioactivities in Plant Extracts)
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9 pages, 1051 KiB  
Article
Myrrh and Chamomile Flower Extract Inhibit Mediator Release from IgE-stimulated Mast-Cell-Like RBL-2H3 Cells
by Fabian Altenbernd, Lena Schwarz, Bartosz Lipowicz and Cica Vissiennon
Plants 2022, 11(24), 3422; https://doi.org/10.3390/plants11243422 - 08 Dec 2022
Viewed by 1808
Abstract
Recent clinical evidence supports the efficacy of a traditional medicinal product (TMP) containing a combination of myrrh (Commiphora myrrha (Nees) Engl.), coffee charcoal (Coffea arabica L.), and chamomile flower dry extract (Matricaria chamomilla L.) in the therapy of diarrhea and [...] Read more.
Recent clinical evidence supports the efficacy of a traditional medicinal product (TMP) containing a combination of myrrh (Commiphora myrrha (Nees) Engl.), coffee charcoal (Coffea arabica L.), and chamomile flower dry extract (Matricaria chamomilla L.) in the therapy of diarrhea and inflammatory bowel disease. Mast cells seem to play a key role in the symptom generation of irritable bowel syndrome (IBS). To evaluate the use of the TMP in IBS treatment, the effects of the herbal extracts on the release of mast-cell mediators from stimulated RBL-2H3 cells were investigated. Therefore, degranulation was induced by phorbol-12-myristate-13-acetate (PMA) and calcium ionophore A13187 (CI) or IgE stimulation, and the amounts of released β-hexosaminidase and histamine were quantified. The extracts showed no effect on the mediator release of PMA- and CI-stimulated RBL-2H3 cells. Myrrh and chamomile were able to reduce the β-hexosaminidase release of IgE-stimulated cells, while myrrh showed stronger inhibition of the mediator release than chamomile, which reduced only IgE-stimulated histamine release. Thus, these results indicate a mechanistic basis for the use of the herbal combination of myrrh, coffee charcoal, and chamomile flower extract in the symptom-oriented treatment of IBS patients with diarrheal symptoms. Full article
(This article belongs to the Special Issue Anti-Inflammatory Bioactivities in Plant Extracts)
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13 pages, 2027 KiB  
Article
The Essential Oil of Hyptis crenata Inhibits the Increase in Secretion of Inflammatory Mediators
by Rutyleia Alves-Soares, Hermógenes David de Oliveira, Dyély de Carvalho Oliveira Campos, Yuri de Abreu Gomes-Vasconcelos, Francisco Walber Ferreira-da-Silva, Kerly Shamyra Silva-Alves, Lianna Noronha Coelho-de-Souza, Lúcio Ricardo Leite Diniz, José Henrique Leal-Cardoso and Andrelina Noronha Coelho-de-Souza
Plants 2022, 11(22), 3048; https://doi.org/10.3390/plants11223048 - 11 Nov 2022
Viewed by 1151
Abstract
Background: Hyptis crenata is a plant of great ethnopharmacological importance widely distributed in South American countries. In Northeast Brazil, teas or infusions of its aerial parts are used in folk medicine to treat several acute and chronic inflammatory diseases. In a previous work [...] Read more.
Background: Hyptis crenata is a plant of great ethnopharmacological importance widely distributed in South American countries. In Northeast Brazil, teas or infusions of its aerial parts are used in folk medicine to treat several acute and chronic inflammatory diseases. In a previous work we have demonstrated that the essential oil of H. crenata (EOHc) has an antiedematogenic effect. The aim of this work was to evaluate the effect of EOHc on cytokines secretion and cellular infiltration. Methods: Peritonitis and paw edema models induced by carrageenan were used to determine leucocyte count, myeloperoxidase (MPO) activity, nitrite, and cytokines secretion. Results: EOHc (10–300 mg/kg) significantly inhibited leucocyte migration and reduced the neutrophil count (control: 1.46 × 103 ± 0.031 × 103/mL) of the total leucocytes population in extracellular exudate (control: 2.14 × 103 ± 0.149 × 103/mL) by 15.00%, 43.29%, 65.52%, and 72.83% for the doses of 10, 30, 100, and 300 mg/kg EOHc, respectively (EC50: 24.15 mg/kg). EOHc (100 mg/kg) inhibited the increase in myeloperoxidase activity and completely blocked the increase in nitrite concentration induced by carrageenan. EOHc markedly reduced the pro-inflammatory cytokines (IL-6, MCP-1, IFN-γ, TNF-α, and IL-12p70) and increased IL-10, an anti-inflammatory cytokine (compared to control group, p < 0.05). Conclusions: This study demonstrates that EOHc has a long-lasting anti-inflammatory effect mediated through interference on MPO activity, and nitrite, and cytokines secretion. This effect, coupled with low EOHc toxicity, as far as results obtained in mice could be translated to humans, suggests that EOHc has great potentiality as a therapeutic agent. Full article
(This article belongs to the Special Issue Anti-Inflammatory Bioactivities in Plant Extracts)
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19 pages, 3397 KiB  
Article
Anti-Apoptotic and Anti-Inflammatory Effects of an Ethanolic Extract of Lycium chinense Root against Particulate Matter 10-Induced Cell Death and Inflammation in RBL-2H3 Basophil Cells and BALB/c Mice
by Jisun Lee, Jin Ree, Hyeon Jeong Kim, Hee Jin Kim, Woo Jung Kim, Tae Gyu Choi, Sanghyun Lee, Yun Ki Hong, Seong Bin Hong and Yong Il Park
Plants 2022, 11(19), 2485; https://doi.org/10.3390/plants11192485 - 22 Sep 2022
Cited by 3 | Viewed by 1576
Abstract
Particulate matters (PMs) from polluted air cause diverse pulmonary and cardiovascular diseases, including lung inflammation. While the fruits (Goji) of Lycium trees are commonly consumed as traditional medicine and functional food ingredients, the majority of their roots are discarded as by-products. To enhance [...] Read more.
Particulate matters (PMs) from polluted air cause diverse pulmonary and cardiovascular diseases, including lung inflammation. While the fruits (Goji) of Lycium trees are commonly consumed as traditional medicine and functional food ingredients, the majority of their roots are discarded as by-products. To enhance the industrial applicability of Lycium roots, we prepared an ethanol extract (named GR30) of L. chinense Miller roots and evaluated its potential protective effects against particulate matter 10 (PM10)-induced inflammation and immune cell death. The GR30 treatment (0–500 μg/mL) significantly attenuated the PM10-induced cell cycle arrest, DNA fragmentation and mitochondria-dependent apoptosis in RBL-2H3 basophil cells. GR30 also significantly antagonized the PM10-induced expression of proinflammatory cytokines (IL-4, IL-13, and TNF-α) and COX2 expression through downregulation of MAPKs (ERK and JNK) signalling pathway. Oral administration of GR30 (200–400 mg/kg) to PM10 (20 mg/mL)-challenged mice significantly reduced the serum levels of IgE and the expression of TNF-α and Bax in lung tissues, which were elevated by PM10 exposure. These results revealed that the ethanolic extract (GR30) of L. chinense Miller roots exhibited anti-inflammatory and cyto-protective activity against PM10-induced inflammation and basophil cell death, and thus, it would be useful in functional food industries to ameliorate PM-mediated damage to respiratory and immune systems. Full article
(This article belongs to the Special Issue Anti-Inflammatory Bioactivities in Plant Extracts)
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18 pages, 3215 KiB  
Article
Angiopteris cochinchinensis de Vriese Ameliorates LPS-Induced Acute Lung Injury via Src Inhibition
by Won Young Jang, Hwa Pyoung Lee, Seung A Kim, Lei Huang, Ji Hye Yoon, Chae Yun Shin, Ankita Mitra, Han Gyung Kim and Jae Youl Cho
Plants 2022, 11(10), 1306; https://doi.org/10.3390/plants11101306 - 13 May 2022
Cited by 9 | Viewed by 3077
Abstract
Growing demand for treatment options against acute lung injury (ALI) emphasizes studies on plant extracts harboring anti-inflammatory effects. According to GC-MS analysis, Angiopteris cochinchinensis de Vriese consists of various flavonoids with anti-inflammatory activities. Thus, in this study, the anti-inflammatory effects of an extract [...] Read more.
Growing demand for treatment options against acute lung injury (ALI) emphasizes studies on plant extracts harboring anti-inflammatory effects. According to GC-MS analysis, Angiopteris cochinchinensis de Vriese consists of various flavonoids with anti-inflammatory activities. Thus, in this study, the anti-inflammatory effects of an extract of Angiopteris cochinchinensis de Vriese (Ac-EE) were assessed using RAW264.6 murine macrophages and a lipopolysaccharide (LPS)-induced ALI model. Ac-EE reduced the nitric oxide production in murine macrophages increased by LPS induction. Moreover, protective effects of Ac-EE on lung tissue were demonstrated by shrinkage of edema and lung injury. Reduced neutrophil infiltration and formation of hyaline membranes were also detected in lung tissues after H&E staining. Semiquantitative RT-PCR, quantitative real-time PCR, and ELISA showed that Ac-EE inhibits the production of proinflammatory mediators, including iNOS and COX-2, and cytokines, such as TNF-α, IL-1β, and IL-6. An Ac-EE-mediated anti-inflammatory response was derived from inhibiting the NF-κB signaling pathway, which was evaluated by luciferase reporter assay and Western blotting analysis. A cellular thermal shift assay revealed that the prime target of Ac-EE in alleviating inflammation was Src. With its direct binding with Src, Angiopteris cochinchinensis de Vriese significantly mitigates lung injury, showing possibilities of its potential as an effective botanical drug. Full article
(This article belongs to the Special Issue Anti-Inflammatory Bioactivities in Plant Extracts)
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20 pages, 3353 KiB  
Article
Mitigation of Gastric Damage Using Cinnamomum cassia Extract: Network Pharmacological Analysis of Active Compounds and Protection Effects in Rats
by Ji Hwan Lee, Hee Jae Kwak, Dongchul Shin, Hye Jin Seo, Shin Jung Park, Bo-Hee Hong, Myoung-Sook Shin, Seung Hyun Kim and Ki Sung Kang
Plants 2022, 11(6), 716; https://doi.org/10.3390/plants11060716 - 08 Mar 2022
Cited by 14 | Viewed by 2815
Abstract
Gastritis is a common disease worldwide that is caused by various causes such as eating habits, smoking, severe stress, and heavy drinking, as well as Helicobacter pylori infections and non-steroidal anti-inflammatory drugs. Cinnamomum cassia is a tropical aromatic evergreen tree commonly used as [...] Read more.
Gastritis is a common disease worldwide that is caused by various causes such as eating habits, smoking, severe stress, and heavy drinking, as well as Helicobacter pylori infections and non-steroidal anti-inflammatory drugs. Cinnamomum cassia is a tropical aromatic evergreen tree commonly used as a natural medicine in Asia and as a functional food ingredient. Studies have reported this species’ anti-obesity, anti-diabetic, and cardiovascular disease suppression effects. We evaluated the potential effects of C. cassia using non-steroidal anti-inflammatory drugs (NSAIDs), ethanol (EtOH), and ethanol/hydrochloric acid (HCl)-induced gastric mucosal injury models. C. cassia extracts reduced the area of gastric mucosa injury caused by indomethacin, NSAID, EtOH, and EtOH/HCl. We also applied a network pharmacology-based approach to identify the active compounds, potential targets, and pharmacological mechanisms of C. cassia against gastritis. Through a network pharmacology analysis, 10 key components were predicted as anti-gastritis effect-related compounds of C. cassia among 51 expected active compounds. The NF-κB signaling pathway, a widely known inflammatory response mechanism, comprised a major signaling pathway within the network pharmacology analysis. These results suggest that the anti-gastritis activities of C. cassia may be induced via the anti-inflammatory effects of key components, which suppress the inflammation-related genes and signaling pathways identified in this study. Full article
(This article belongs to the Special Issue Anti-Inflammatory Bioactivities in Plant Extracts)
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