Phytochemical and Biological Activity of Plant Extracts

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 3164

Special Issue Editors


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Guest Editor
Grupo QBAB, Instituto de Ciencias Químicas Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, San Miguel, Santiago 8900000, Chile
Interests: application of natural products on agriculture; synthesis of natural products analogs; structure–activity relationships; development of formulations using bioactive natural products and nanomaterials

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Guest Editor
Grupo QBAB, Instituto de Ciencias Químicas Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, San Miguel, Santiago 8900000, Chile
Interests: organic chemistry; organic synthesis; natural products research; biological activity of natural compounds and derivatives

Special Issue Information

Dear Colleagues,

For a long time, plants have been a significant source of compounds with biological activity, and they have even been used as alternative medicine in diverse cultures around the world for centuries. It is well established that these activities are associated with the great number of secondary metabolites produced by plants to adapt themselves to the environment where they grow. As environmental conditions can change drastically from one place to another, or even in the same place due to climatic change or exogenous parameters, the chemical nature and relative concentration of metabolites change as well.

Therefore, this Special Issue focuses on phytochemical studies aimed to isolate and characterize natural products or to determine the chemical composition pattern that could be responsible for plant biological activities. The chemical modification of secondary metabolites to get synthetic plant analogs to establish structure–activity relationships or to increase their therapeutic or preventive properties will also be considered. On the other hand, studies of the composition and bioactivity of extracts obtained from different plant varieties or growth locations, or by different extraction methods will be also considered.

Dr. F. Olea Andres
Dr. Héctor Carrasco
Guest Editors

Manuscript Submission Information

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Keywords

  • natural products
  • plant extracts
  • extraction methods
  • synthetic analogs
  • biological activities of plant extracts
  • bioactive natural products

Published Papers (3 papers)

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Research

12 pages, 2093 KiB  
Article
Influence of β-Ionone in the Phytotoxicity of the Rhizome of Iris pallida Lam
by Yourk Sothearith, Kwame Sarpong Appiah, Chhin Sophea, Jady Smith, Say Samal, Takashi Motobayashi and Yoshiharu Fujii
Plants 2024, 13(2), 326; https://doi.org/10.3390/plants13020326 - 22 Jan 2024
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Abstract
Iris pallida Lam., also known as Sweetie Iris, is a perennial ornamental and medicinal plant that produces a wide range of secondary metabolites. The Sweetie Iris was recently reported to have high allelopathic properties with the potential to be explored in sustainable weed [...] Read more.
Iris pallida Lam., also known as Sweetie Iris, is a perennial ornamental and medicinal plant that produces a wide range of secondary metabolites. The Sweetie Iris was recently reported to have high allelopathic properties with the potential to be explored in sustainable weed management. This study aimed to identify and evaluate the contributions of compounds involved in the inhibitory effects of the rhizome of Sweetie Iris. High-performance liquid chromatography (HPLC) analysis was used to determine the content of β-ionone in the rhizome of Sweetie Iris. The phytotoxicity of β-ionone was evaluated on lettuce (Lactuca sativa L.) and other test plants. The content of β-ionone in the crude extract of Sweetie Iris rhizome was found to be 20.0 mg g−1 by HPLC analysis. The phytotoxicity bioassay showed that β-ionone had strong inhibitory activity on the growth of lettuce (Lactuca sativa L.) and the other test plants, including Taraxacum officinale, Stellaria media, Eleusine indica, Amaranthus hybridus, Vicia villosa, and Brassica napus. At a concentration of 23.0 µg mL−1, β-ionone inhibited the growth of all test plant species treated. Therefore, β-ionone is an active compound among the other allelopathic substances contained in the rhizome of Sweetie Iris. Full article
(This article belongs to the Special Issue Phytochemical and Biological Activity of Plant Extracts)
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17 pages, 5359 KiB  
Article
Green Extraction Techniques of Phytochemicals from Hedera helix L. and In Vitro Characterization of the Extracts
by Adina I. Gavrila, Christina M. Zalaru, Rodica Tatia, Ana-Maria Seciu-Grama, Cristina L. Negrea, Ioan Calinescu, Petre Chipurici, Adrian Trifan and Ioana Popa
Plants 2023, 12(22), 3908; https://doi.org/10.3390/plants12223908 - 20 Nov 2023
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Abstract
Hedera helix L. contains phytochemicals with good biological properties which are beneficial to human health and can be used to protect plants against different diseases. The aim of this research was to find the most suitable extraction method and the most favorable parameters [...] Read more.
Hedera helix L. contains phytochemicals with good biological properties which are beneficial to human health and can be used to protect plants against different diseases. The aim of this research was to find the most suitable extraction method and the most favorable parameters for the extraction of different bioactive compounds from ivy leaves. Different extraction methods, namely microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), and conventional heating extraction (CHE), were used. The most suitable method for the extraction of saponins is MAE with an extraction efficiency of 58%, while for carbohydrates and polyphenols, the best results were achieved via UAE with an extraction efficiency of 61.7% and 63.5%, respectively. The antioxidant activity (AA) of the extracts was also determined. The highest AA was obtained via UAE (368.98 ± 9.01 µmol TR/gDM). Better results were achieved at 50 °C for 10 min of extraction, using 80% ethanol in water as solvent. In order to evaluate their in vitro cytotoxicity, the extracts richest in bioactive compounds were tested on NCTC fibroblasts. Their influence on the DNA content of RAW 264.7 murine macrophages was also tested. Until 200 µg/mL, the extracts obtained via UAE and MAE were cytocompatible with NCTC fibroblasts at 48 h of treatment. Summarizing the above, both MAE and UAE can be employed as green and efficient methods for producing extracts rich in bioactive compounds, exhibiting strong antioxidant properties and good noncytotoxic activity. Full article
(This article belongs to the Special Issue Phytochemical and Biological Activity of Plant Extracts)
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19 pages, 3138 KiB  
Article
Pentaclethra eetveldeana Leaves from Four Congo-Brazzaville Regions: Antioxidant Capacity, Anti-Inflammatory Activity and Proportional Accumulation of Phytochemicals
by Victor N’goka, Sandrine Lydie Oyegue Liabagui, Cédric Sima Obiang, Herman Begouabe, Gelase Fredy Nsonde Ntandou, Romeo Karl Imboumy-Limoukou, Jean-Claude Biteghe-Bi-Essone, Brice Serge Kumulungui, Jean Bernard Lekana-Douki and Ange Antoine Abena
Plants 2023, 12(18), 3271; https://doi.org/10.3390/plants12183271 - 15 Sep 2023
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Abstract
Oxidative stress and inflammation play a key role in the occurrence of neurodegenerative diseases. Traditionally, Pentaclethra eetveldeana leaves are used in dementia treatment. Therefore, this study aimed to evaluate the antioxidant and anti-inflammatory activities as well as the phytochemical composition of Pentaclethra eetveldeana [...] Read more.
Oxidative stress and inflammation play a key role in the occurrence of neurodegenerative diseases. Traditionally, Pentaclethra eetveldeana leaves are used in dementia treatment. Therefore, this study aimed to evaluate the antioxidant and anti-inflammatory activities as well as the phytochemical composition of Pentaclethra eetveldeana leaves from four Congo-Brazzaville regions. The 1.2-diphenyl-1-picrylhydrazyl radical-scavenging, β-carotene bleaching and molybdenum reduction assays were used to assess the antioxidant activity. The protein denaturation and erythrocyte membrane stabilization tests were used to analyze the anti-inflammatory activity. Phytochemical screening, the quantification of polyphenols by spectrophotometry, as well as the determination of extraction yields were carried out. It was found that the extracts reduced molybdenum; furthermore, compared to ascorbic acid, they showed better antiradical activity and inhibited lipid peroxidation. Moreover, globally, the membrane-stabilizing power of the aqueous extracts was superior or comparable to diclofenac, while the same extracts were less effective for the inhibition of denaturation. All of the aqueous extracts contained polyphenols, saponins, alkaloids, anthraquinones, reducing sugar and cardiotonic glycosides. The total polyphenols, tannins and proanthocyanidins are produced proportionally from one region to another. Finally, the leaves from Brazzaville and Boundji contain flavonols, while those from Makoua and Owando contain flavones. Thus, Pentaclethra eetveldeana leaves contribute to traditional dementia treatment through their antioxidant and anti-inflammatory properties. Full article
(This article belongs to the Special Issue Phytochemical and Biological Activity of Plant Extracts)
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