Cardiac Physiology and Pathophysiology

A special issue of Physiologia (ISSN 2673-9488).

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 3291

Special Issue Editor


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Guest Editor
School of Health Sciences, Liverpool Hope University, Liverpool L16 9JD, UK
Interests: cardiac physiology; strength and conditioning; anabolic steroids; supplementation

Special Issue Information

Dear Colleagues,

Cardiac structure and functions have long been shown to adapt in response to a broad range of stimuli. Disease states, acute and chronic exercise training, drugs and supplements for health, performance-enhancing and recreational drugs can all impact cardiac structure and function.

Similar structural and functional responses can be observed in response to these different stimuli. Therefore, appreciating the scale and type of adaptations that occur and how these responses translate to health and performance outcomes is an important aspect for cardiac physiologists to understand.

Thus, the aim of this Special Issue is to highlight the scale and breadth of structural and functional changes that can occur in response to a broad spectrum of stimuli and how they impact health and performance outcomes.

Dr. Peter Angell
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac structure and functions
  • disease states
  • acute and chronic exercise training
  • drugs

Published Papers (1 paper)

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30 pages, 2831 KiB  
Systematic Review
Remodeling in Persistent Atrial Fibrillation: Pathophysiology and Therapeutic Targets—A Systematic Review
by Attila Roka and Isaac Burright
Physiologia 2023, 3(1), 43-72; https://doi.org/10.3390/physiologia3010004 - 09 Jan 2023
Cited by 4 | Viewed by 2840
Abstract
Atrial fibrillation (AF) is characterized by disorganized rapid atrial electrical activity, which leads to impaired atrial function, adverse hemodynamic effects, and increased thromboembolic risk. The paroxysmal forms of AF can be effectively treated with current pharmacological and non-pharmacological modalities by targeting the arrhythmia [...] Read more.
Atrial fibrillation (AF) is characterized by disorganized rapid atrial electrical activity, which leads to impaired atrial function, adverse hemodynamic effects, and increased thromboembolic risk. The paroxysmal forms of AF can be effectively treated with current pharmacological and non-pharmacological modalities by targeting the arrhythmia triggers. Persistent AF, however, is more difficult to treat due to remodeling processes which may become major factors in the maintenance of the arrhythmia, rendering trigger-targeting treatment options less effective. We will systematically review the recent findings of the development and maintenance of persistent AF, including genetic, cellular, organ level, and systemic processes. As AF remains the most common sustained arrhythmia with the ongoing need to find effective treatment, we will also discuss potential treatment options targeting the remodeling processes. Full article
(This article belongs to the Special Issue Cardiac Physiology and Pathophysiology)
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