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Pharmaceutics
Special Issues
Topical Microemulsion Formulation for Transdermal Drug Delivery
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Topical Microemulsion Formulation for Transdermal Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 1533

Special Issue Editors

Prof. Dr. Pao-Chu Wu

E-Mail Website
Guest Editor
School of Pharmacy, Collage of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Interests: drug delivery systems; transdermal drug delivery; pharmaceutical dosage forms; microemulsion; liposome
Special Issues, Collections and Topics in MDPI journals
Dr. Yi-Ping Fang

E-Mail Website
Guest Editor
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Interests: nanomedicine; biomaterials; topical/transdermal delivery; photodynamic therapy; pharmaceutical engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are planning to publish a Special Issue based on “Topical Microemulsion Formulation for Transdermal Drug Delivery” in the journal Pharmaceutics.

Transdermal drug delivery systems play an important role in the delivery of drugs with low permeability through the skin by enhancing their permeability and treatment action, avoiding the hepatic first passage, and reducing toxicity. Recently, new optimized approaches have been developed for transdermal drug delivery with the purpose of avoiding and overcoming the complications of drugs generated as a result of other drug delivery systems.   

This Special Issue aims to highlight and capture the challenges faced by the low permeable soluble drugs by developing a topical microemulsion formulation for transdermal drug delivery. We invite articles based on novel topical microemulsion formulations to overcome the challenges generated as a result of drug administrations.

We look forward to receiving your contributions.

Prof. Dr. Pao-Chu Wu
Dr. Yi-Ping Fang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microemulsion
  • topical delivery
  • transdermal delivery
  • biomedical application
  • formulation design
  • self-emulsifying/microemulsifying drug delivery system (SEDDS/SMEDDS)

Published Papers (1 paper)

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Research

13 pages, 1897 KiB  
Article
Improvement in Skin Penetration Capacity of Linalool by Using Microemulsion as a Delivery Carrier: Formulation Optimization and In Vitro Evaluation
by Ming-Jun Tsai, Wen-Yu Chang, I-Hui Chiu, I-Ling Lin and Pao-Chu Wu
Pharmaceutics 2023, 15(5), 1446; https://doi.org/10.3390/pharmaceutics15051446 - 09 May 2023
Viewed by 1172
Abstract
Linalool is an aromatic oil with analgesic, anti-inflammatory and anti-UVB-induced skin damage effects. The aim of this study was to develop a linalool-loaded microemulsion formulation for topical application. In order to quickly obtain an optimal drug-loaded formulation, statistical tools of the response surface [...] Read more.
Linalool is an aromatic oil with analgesic, anti-inflammatory and anti-UVB-induced skin damage effects. The aim of this study was to develop a linalool-loaded microemulsion formulation for topical application. In order to quickly obtain an optimal drug-loaded formulation, statistical tools of the response surface methodology and a mixed experimental design with four independent variables of oil (X1), mixed surfactant (X2), cosurfactant (X3) and water (X4) were used to design a series of model formulations in order to analyze the effect of the composition on the characteristics and permeation capacity of linalool-loaded microemulsion formulations and to obtain an appropriate drug-loaded formulation. The results showed that the droplet size, viscosity and penetration capacity of linalool-loaded formulations were significantly affected by formulation component proportions. The skin deposition amount of the drug and flux of such formulations expressively increased about 6.1-fold and 6.5-fold, respectively, when compared to the control group (5% linalool dissolved in ethanol). After 3 months of storage, the physicochemical characteristics and drug level did not show a significant change. The linalool formulation-treated rat skin showed non-significant irritation compared to skin treatments in the distilled-water-treated group. The results showed that specific microemulsion applications might be considered as potential drug delivery carriers for essential oil topical application. Full article
(This article belongs to the Special Issue Topical Microemulsion Formulation for Transdermal Drug Delivery)
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