Organoids and Spheroids for the Design and the Evaluation of Therapeutic Strategies
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 12483
Special Issue Editors
Interests: microbubbles; ultrasound; sonoporation; ultrasound imaging; drug and gene delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Spheroids and organoids are small, self-organized and three-dimensional tissue systems. The growing interest in the use of these systems arises from their ability to mimic the physiology and pathophysiology of a specific tissue or organ in vitro. They are promising in vitro microphysiological systems for the modeling of physiological (morphogenesis, organogenesis) and pathophysiological (cancer, brain disorders, etc.) processes, for developing regenerative medicine and tissue engineering (bone/cartilage defects, critical limb ischemia, etc.), for designing and validating treatments (drug screening, drug toxicity, drug-delivery systems, etc.) and for identifying diagnosis biomarkers. The three-dimensional architecture of these systems allows the many restrictions of two-dimensional cell culture systems to be overcome. Indeed, spheroids and organoids reproduce the cellular microenvironment of a specific tissue or organ, thus replicating cellular and molecular interactions, as well as biochemical and biomechanical signaling pathways, which determine the cell’s fate within that specific tissue or organ. Finally, these in vitro 3D systems can show great potential in acquiring data more efficiently and economically than animal models, which could help to reduce the use of animal models.
The present Special Issue in Pharmaceutics aims to gather a collection of research articles or reviews describing the use of organoids and spheroids to design and/or validate:
- drug design;
- drug screening;
- drug targeting;
- drug delivery methods;
- drug toxicity.
We are also open to any other topics that authors may wish to submit, provided their relevance is clear.
Prof. Jean-Michel Escoffre
Dr. Dévina C. Ung
Guest Editors
Manuscript Submission Information
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