Skin Performance of Drug Delivery Systems: Scope, Challenges and Future Research and Regulatory Prospects
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 73078
Special Issue Editors
Interests: nanoplatforms for brain and skin delivery; innovative biocompatible excipients; poorly water-soluble drugs; physicochemical/in vitro/in silico characterization methods; in vivo pharmacokinetics in rats
Special Issues, Collections and Topics in MDPI journals
Interests: (trans)dermal delivery systems; film-forming polymers; polysaccharide excipients; in vitro/in vivo characterization; tape stripping
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Skin performance is an umbrella term for diverse attributes of topical products, ranging from bulk aesthetics to permeation testing. Although recent regulatory guidelines favour a patient-focused approach to topical product design, clear input on the suitable characterization techniques is often lacking, leaving opportunity for researchers in the field to contribute through novel or optimised testing protocols. Patient acceptability and adherence rely on a complex interplay of formulation attributes possibly discerned by rheology, texture, tribology and/or sensory profiling. The feel attributed to conventional dosage forms in terms of emolliency or occlusion is acknowledged, but inadequately assessed in case of innovative delivery systems. Finally, the transformation or metamorphosis phenomenon of certain formulations upon topical application needs special consideration, being directly responsible for effective drug delivery revealed via drug release and permeation testing. Therefore, both patient expectations and regulatory inclinations of topical formulations imply a need for tailored characterisation approaches.
Dr. Snezana Savic
Dr. Ivana Pantelić
Guest Editors
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Keywords
- topical drug delivery systems
- formulation metamorphosis
- patient acceptability
- analysis of texture
- rheology
- tribology
- substantivity
- sensory profiling
- in silico/in vitro/in vivo efficacy testing of skin performance