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Special Issue "Solubilization and Controlled Release of Poorly Water-Soluble Drugs"
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 30445
Special Issue Editors
Interests: controlled bioavailability of poorly soluble and poorly absorbable drugs; solubilization, formulation, and development of patient-centric dosage forms; advanced nano-based delivery systems using fattigation (fatty acid conjugation) and click chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: bioavailability; solubilization technology; controlled delivery systems; targeted nano-delivery systems; extracellular vesicles; theranostics
Special Issue Information
In the last decade, emerging trends in combinatorial chemistry and drug design have rendered newly developed drug molecules with higher lipophilicity, larger molecular weight, and poor water solubility. These properties are associated with a variety of rate limiting dissolution, slow absorption, and low bioavailability that may lead to the failures of developing many promising agents, including lead compounds, in vital therapeutic areas. At first, the optimization of physicochemical properties of such poorly water-soluble molecules for enhanced solubility, dissolution, and ultimately enhanced bioavailability is the most important prerequisite for pharmaceutical researchers to develop drug products. A variety of approaches have been used to overcome the poor water solubility and enhance the dissolution rate of drugs, such as solid dispersion, salt formation, supercritical fluid technology, prodrugs, co-crystal formation, cyclodextrin complexes, lipid-based formulations, and nanosized drug delivery systems, etc. Secondly, to achieve an appropriate delivery system of poorly water soluble drugs that can modulate the drug release at desired rates, times and/ or locations for an effective medication, state-of-art technologies of engineering the surface of delivery systems as well as a modification of the payload are taken into consideration. Of note, once these delivery systems are formulated to satisfy enhanced solubility and controlled release, they offer several patient-centered advantages, such as reduced high total doses, reduced dosing frequency, and gastrointestinal side effects, and improved patient acceptance and compliance. In addition, the most up-to-date studies have showcased promising natural delivery systems of poor water molecules with versatile and multifunctional activities as the next generation of theranostic (therapeutic and diagnostic) applications in medicine.
This Special Issue aims to highlight the latest progress and research of pharmaceutical and biopharmaceutical technologies to address and solve the problems of poorly water-soluble drugs, as well as present innovative delivery systems of these drugs and formulation of various routes of administration via solubilization and controlled release. The Special Issue also covers studies that could help shed light on how the new delivery systems worked out to present the most relevant contributions in developing effective medical applications of poorly water soluble drugs for patient centricity.
Prof. Dr. Beom-Jin Lee
Dr. Phuong Ha-Lien Tran
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- solubilization technology
- controlled release
- poorly water soluble drug
- drug delivery sytems
- formulation of various routes of administration
- pharmaceutical technology
- surface engineering
- therapeutics/ Diagnostics
- patient centricity and unmet medical needs