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Pharmaceutics
Special Issues
New Pharmaceutical Applications through 3D Printing Processes
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New Pharmaceutical Applications through 3D Printing Processes

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 22314

Special Issue Editors

Dr. Mattia Tiboni

E-Mail Website
Guest Editor
Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy
Interests: 3D printing; additive manufacturing; hot melt extrusion; microfluidics; nanomedicine
Dr. Annalisa Aluigi

E-Mail Website
Guest Editor
Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy
Interests: 3D printing; electrospinning; biopolymers; nanomaterials; drug delivery

Special Issue Information

Dear Colleagues,

Additive manufacturing and 3D printing (3DP) are technologies with a growing interest in the pharmaceutical field. During the last decade, new techniques, innovative applications, and different materials have been developed and tested. Not only the direct production of pharmaceutical forms but also the development of manufacturing and analytical systems has been explored. The use of 3D-printing technologies opens new opportunities for the manufacturing of personalized dosage forms and medical devices tunable for the patient’s needs, but also for the development and personalization of manufacturing and analytical systems based on researchers’ needs. Nevertheless, since pharmaceutical 3DP is still a growing field, different requests still have to be explored, such as the improvement of pharma dedicated 3D printers and production lines, as well as the advancement of dedicated printable excipients.

This Special Issue will collect contributions about innovative materials, innovative techniques, and innovative approaches using 3D printing with a pharmaceutical endpoint.

Dr. Mattia Tiboni
Dr. Annalisa Aluigi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • additive manufacturing
  • 3D Printing
  • 3DP excipients
  • innovative materials
  • drug delivery
  • quality control
  • pharmaceutical manufacturing
  • microfluidics

Published Papers (4 papers)

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Research

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16 pages, 1621 KiB  
Article
Three-Dimensionally Printed Vaginal Rings: Perceptions of Women and Gynecologists in a Cross-Sectional Survey
by Laura Andrade Junqueira, Francisco José Raposo, Geraldo Sérgio Farinazzo Vitral, Atabak Ghanizadeh Tabriz, Dennis Douroumis, Nádia Rezende Barbosa Raposo and Marcos Antônio Fernandes Brandão
Pharmaceutics 2023, 15(9), 2302; https://doi.org/10.3390/pharmaceutics15092302 - 11 Sep 2023
Cited by 1 | Viewed by 948
Abstract
Three-dimensional printing technologies can be implemented for the fabrication of personalized vaginal rings (VRs) as an alternative approach to traditional manufacturing. Although several studies have demonstrated the potential of additive manufacturing, there is a lack of knowledge concerning the opinions of patients and [...] Read more.
Three-dimensional printing technologies can be implemented for the fabrication of personalized vaginal rings (VRs) as an alternative approach to traditional manufacturing. Although several studies have demonstrated the potential of additive manufacturing, there is a lack of knowledge concerning the opinions of patients and clinicians. This study aimed to investigate the perception of women and gynecologists regarding VRs with personalized shapes. The devices were printed with different designs (traditional, “Y”, “M”, and flat circle) by Fused Deposition Modeling for a cross-sectional survey with 155 participants. Their anticipated opinion was assessed through a questionnaire after a visual/tactile analysis of the VRs. The findings revealed that most women would feel comfortable using some of the 3D-printed VR designs and demonstrated good acceptability for the traditional and two innovative designs. However, women presented multiple preferences when the actual geometry was assessed, which directly related to their age, previous use of the vaginal route, and perception of comfort. In turn, gynecologists favored prescribing traditional and flat circle designs. Overall, although there was a difference in the perception between women and gynecologists, they had a positive opinion of the 3D-printed VRs. Finally, the personalized VRs could lead to an increase in therapeutic adherence, by meeting women’s preferences. Full article
(This article belongs to the Special Issue New Pharmaceutical Applications through 3D Printing Processes)
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19 pages, 2372 KiB  
Article
The Quest for Child-Friendly Carrier Materials Used in the 3D Semi-Solid Extrusion Printing of Medicines
by Eveline E. M. van Kampen, Sejad Ayyoubi, Luc Willemsteijn, Kjeld J. C. van Bommel and Elisabeth J. Ruijgrok
Pharmaceutics 2023, 15(1), 28; https://doi.org/10.3390/pharmaceutics15010028 - 21 Dec 2022
Cited by 3 | Viewed by 2540
Abstract
This work gives a brief overview of carrier materials currently used in pharmaceutical studies on the three-dimensional (3D) semi-solid extrusion (SSE) printing of medicines for pediatrics. The suitability of using these carrier materials in pediatric formulations, concerning safety and toxicity, was reviewed by [...] Read more.
This work gives a brief overview of carrier materials currently used in pharmaceutical studies on the three-dimensional (3D) semi-solid extrusion (SSE) printing of medicines for pediatrics. The suitability of using these carrier materials in pediatric formulations, concerning safety and toxicity, was reviewed by consulting the ‘Safety & Toxicity of Excipients for Pediatrics’ (STEP) database and the Food and Drug Administration (FDA) regulations. In the second part of this work, carrier materials were tested on their ability to form a semi-solid mixture with lactose by dual asymmetric centrifugation (DAC) and printing by SSE. With the combination of theoretical and experimental studies, this work will guide research toward grounded decision-making when it comes to carrier material selection for pharmaceutical pediatric 3D SSE printing formulations. Full article
(This article belongs to the Special Issue New Pharmaceutical Applications through 3D Printing Processes)
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Review

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35 pages, 8382 KiB  
Review
3D Bioprinted Chitosan-Based Hydrogel Scaffolds in Tissue Engineering and Localised Drug Delivery
by Maria Lazaridou, Dimitrios N. Bikiaris and Dimitrios A. Lamprou
Pharmaceutics 2022, 14(9), 1978; https://doi.org/10.3390/pharmaceutics14091978 - 19 Sep 2022
Cited by 32 | Viewed by 7549
Abstract
Bioprinting is an emerging technology with various applications in developing functional tissue constructs for the replacement of harmed or damaged tissues and simultaneously controlled drug delivery systems (DDSs) for the administration of several active substances, such as growth factors, proteins, and drug molecules. [...] Read more.
Bioprinting is an emerging technology with various applications in developing functional tissue constructs for the replacement of harmed or damaged tissues and simultaneously controlled drug delivery systems (DDSs) for the administration of several active substances, such as growth factors, proteins, and drug molecules. It is a novel approach that provides high reproducibility and precise control over the fabricated constructs in an automated way. An ideal bioink should possess proper mechanical, rheological, and biological properties essential to ensure proper function. Chitosan is a promising natural-derived polysaccharide to be used as ink because of its attractive properties, such as biodegradability, biocompatibility, low cost, and non-immunogenicity. This review focuses on 3D bioprinting technology for the preparation of chitosan-based hydrogel scaffolds for the regeneration of tissues delivering either cells or active substances to promote restoration. Full article
(This article belongs to the Special Issue New Pharmaceutical Applications through 3D Printing Processes)
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36 pages, 15663 KiB  
Review
Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design
by Lucía Rodríguez-Pombo, Atheer Awad, Abdul W. Basit, Carmen Alvarez-Lorenzo and Alvaro Goyanes
Pharmaceutics 2022, 14(8), 1732; https://doi.org/10.3390/pharmaceutics14081732 - 18 Aug 2022
Cited by 14 | Viewed by 9158
Abstract
Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include veterinary applications, improving administration and palatability in different animal species. Despite [...] Read more.
Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include veterinary applications, improving administration and palatability in different animal species. Despite their advantages, current chewable formulations do not account for individualised dosing and palatability preferences. In light of this, three-dimensional (3D) printing, and in particular the semi-solid extrusion technology, has been suggested as a novel manufacturing method for producing customised chewable dosage forms. This advanced approach offers flexibility for selecting patient-specific doses, excipients, and organoleptic properties, which are critical for ensuring efficacy, safety and adherence to the treatment. This review provides an overview of the latest advancements in chewable dosage forms for human and veterinary use, highlighting the motivations behind their use and covering formulation considerations, as well as regulatory aspects. Full article
(This article belongs to the Special Issue New Pharmaceutical Applications through 3D Printing Processes)
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