Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Polymer and Lipid-based Materials for Nanodrug Delivery Systems
share announcement

Polymer and Lipid-based Materials for Nanodrug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (10 July 2022) | Viewed by 7145

Special Issue Editors

Dr. Yao Jiang

E-Mail Website
Guest Editor
Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford OX1 2JD, UK
Interests: haematology and ontology; cancer biology; myeloma and Leukemia; drug delivery for cancer
Dr. Yifeng Cao

E-Mail Website
Guest Editor
Institute of Electronic Chemicals, Institute of Zhejiang University-Quzhou, Quzhou 32400, China
Interests: intermolecular and surface interactions; bilubrication; separation and purification

Special Issue Information

Dear Colleagues,

Biocompatible natural and synthetic materials have been designed for use in nanodrug delivery systems for several decades. They have improved the delivery and efficacy of a range of pharmaceutical compounds including drugs, genes, antibodies, peptides, and vaccines. In particular, polymer and lipid-based materials for drug delivery have been paid great attention. Many of these materials have been designed to enhance the delivery of a therapeutic to its target site and minimize off-target accumulation.

This Special Issue focuses on the key findings and contributions regarding novel nanodrug delivery systems for therapy, diagnostics, and bioimaging. In this issue, we welcome original research articles and reviews related to topics including (but not limited to) the design, synthesis, and characterization of nano-formulations for the delivery of drugs, mRNA, photosensitizers, nanoenzymes, and lubricants; novel therapeutic approaches involving targeted delivery using designed functional nanocarriers; controlled release systems that can be magnetically, ultrasonically, or enzymatically triggered to increase release rates.

Dr. Yao Jiang
Dr. Yifeng Cao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liposomes
  • nanoparticles
  • micelles
  • polymers
  • prodrug
  • drug screening platform
  • targeted therapy
  • drug delivery system
  • theranostics
  • transport phenomena

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

19 pages, 4227 KiB  
Article
Transferrin-Enabled Blood–Brain Barrier Crossing Manganese-Based Nanozyme for Rebalancing the Reactive Oxygen Species Level in Ischemic Stroke
by Qianqian Zhao, Wenxian Du, Lingling Zhou, Jianrong Wu, Xiaoxing Zhang, Xiaoer Wei, Sijia Wang, Yu Huang and Yuehua Li
Pharmaceutics 2022, 14(6), 1122; https://doi.org/10.3390/pharmaceutics14061122 - 25 May 2022
Cited by 15 | Viewed by 2317
Abstract
(1) Background: Acute ischemic stroke (IS) is one of the main causes of human disability and death. Therefore, multifunctional nanosystems that effectively cross the blood–brain barrier (BBB) and efficiently eliminate reactive oxygen species (ROS) are urgently needed for comprehensive neuroprotective effects. (2) Methods: [...] Read more.
(1) Background: Acute ischemic stroke (IS) is one of the main causes of human disability and death. Therefore, multifunctional nanosystems that effectively cross the blood–brain barrier (BBB) and efficiently eliminate reactive oxygen species (ROS) are urgently needed for comprehensive neuroprotective effects. (2) Methods: We designed a targeted transferrin (Tf)-based manganese dioxide nanozyme (MnO2@Tf, MT) using a mild biomimetic mineralization method for rebalancing ROS levels. Furthermore, MT can be efficiently loaded with edaravone (Eda), a clinical neuroprotective agent, to obtain the Eda-MnO2@Tf (EMT) nanozyme. (3) Results: The EMT nanozyme not only accumulates in a lesion area and crosses the BBB but also possesses satisfactory biocompatibility and biosafety based on the functional inheritance of Tf. Meanwhile, EMT has intrinsic hydroxyl radical-scavenging ability and superoxide-dismutase-like and catalase-like nanozyme abilities, allowing it to ameliorate ROS-mediated damage and decrease inflammatory factor levels in vivo. Moreover, the released Mn2+ ions in the weak acid environment of the lesion area can be used for magnetic resonance imaging (MRI) to monitor the treatment process. (4) Conclusions: Our study not only paves a way to engineer alternative targeted ROS scavengers for intensive reperfusion-induced injury in ischemic stroke but also provides new insights into the construction of bioinspired Mn-based nanozymes. Full article
(This article belongs to the Special Issue Polymer and Lipid-based Materials for Nanodrug Delivery Systems)
►▼ Show Figures

Figure 1

13 pages, 2569 KiB  
Article
High Performance Gold Nanorods@DNA Self-Assembled Drug-Loading System for Cancer Thermo-Chemotherapy in the Second Near-Infrared Optical Window
by Wei Chang, Junfeng Wang, Jing Zhang, Qing Ling, Yumei Li and Jie Wang
Pharmaceutics 2022, 14(5), 1110; https://doi.org/10.3390/pharmaceutics14051110 - 23 May 2022
Cited by 8 | Viewed by 2147
Abstract
In terms of synergistic cancer therapy, biological nanomaterials with a second near-infrared (NIR-II) window response can greatly increase photothermal effects and photoacoustic imaging performance. Herein, we report a novel stimuli-responsive multifunctional drug-loading system which was constructed by integrating miniature gold nanorods (GNR) as [...] Read more.
In terms of synergistic cancer therapy, biological nanomaterials with a second near-infrared (NIR-II) window response can greatly increase photothermal effects and photoacoustic imaging performance. Herein, we report a novel stimuli-responsive multifunctional drug-loading system which was constructed by integrating miniature gold nanorods (GNR) as the NIR-II photothermal nanorods and cyclic ternary aptamer (CTA) composition as a carrier for chemotherapy drugs. In this system, doxorubicin hydrochloride (DOX, a chemotherapy drug) binds to the G-C base pairs of the CTA, which exhibited a controlled release behavior based on the instability of G-C base pairs in the slightly acidic tumor microenvironment. Upon the 1064 nm (NIR-II biowindow) laser irradiation, the strong photothermal and promoted cargo release properties endow gold nanorods@CTA (GNR@CTA) nanoparticles displaying excellent synergistic anti-cancer effect. Moreover, the GNR@CTA of NIR also possesses thermal imaging and photoacoustic (PA) imaging properties due to the strong NIR region absorbance. This work enables to obtaining a stimuli-responsive “all-in-one” nanocarrier, which are promising candidate for bimodal imaging diagnosis and chemo-photothermal synergistic therapy. Full article
(This article belongs to the Special Issue Polymer and Lipid-based Materials for Nanodrug Delivery Systems)
►▼ Show Figures

Figure 1

Review

Jump to: Research

22 pages, 4989 KiB  
Review
Vascular Repair by Grafting Based on Magnetic Nanoparticles
by Xin Liu, Nan Wang, Xiyu Liu, Rongrong Deng, Ran Kang and Lin Xie
Pharmaceutics 2022, 14(7), 1433; https://doi.org/10.3390/pharmaceutics14071433 - 08 Jul 2022
Cited by 3 | Viewed by 2021
Abstract
Magnetic nanoparticles (MNPs) have attracted much attention in the past few decades because of their unique magnetic responsiveness. Especially in the diagnosis and treatment of diseases, they are mostly involved in non-invasive ways and have achieved good results. The magnetic responsiveness of MNPs [...] Read more.
Magnetic nanoparticles (MNPs) have attracted much attention in the past few decades because of their unique magnetic responsiveness. Especially in the diagnosis and treatment of diseases, they are mostly involved in non-invasive ways and have achieved good results. The magnetic responsiveness of MNPs is strictly controlled by the size, crystallinity, uniformity, and surface properties of the synthesized particles. In this review, we summarized the classification of MNPs and their application in vascular repair. MNPs mainly use their unique magnetic properties to participate in vascular repair, including magnetic stimulation, magnetic drive, magnetic resonance imaging, magnetic hyperthermia, magnetic assembly scaffolds, and magnetic targeted drug delivery, which can significantly affect scaffold performance, cell behavior, factor secretion, drug release, etc. Although there are still challenges in the large-scale clinical application of MNPs, its good non-invasive way to participate in vascular repair and the establishment of a continuous detection process is still the future development direction. Full article
(This article belongs to the Special Issue Polymer and Lipid-based Materials for Nanodrug Delivery Systems)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop