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Journals
Pharmaceutics
Special Issues
Nose-To-Brain Drug Delivery System
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Nose-To-Brain Drug Delivery System

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 5051

Special Issue Editor

Dr. Takanori Kanazawa

E-Mail Website1 Website2
Guest Editor
School of Pharmaceutical Sciences, Department of Pharmaceutical Engineering and Drug Delivery Sciences, University of Shizuoka, Shizuoka, Japan
Interests: drug delivery system; ASO/siRNA delivery; nose-to-brain delivery; topical application; polymer-based micelles; liposomes; functional peptides; spinal cord diseases; CNS disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In order to develop therapeutic drugs for the central nervous system diseases such as dementia, cerebrovascular disorder, brain tumor, and genetic rare diseases, it is very important to establish a drug delivery system (DDS) for the transport of drugs into the brain that can be applied to various drug modalities. In recent years, nasal administration has attracted attention as a nose-to-brain drug delivery method that provides a direct delivery route to the brain without needing to go through the blood–brain barrier. In addition, the number of reports that shows that nanocarriers enhance nose-to-brain drug delivery has been increasing in recent years.

This Special Issue would like to drive the establishment of a universal nose-to-brain DDS by showcasing the latest nanocarrier-based nose-to-brain DDS research considering theoretical aspects according to the physical structure of the nasal mucosal barrier and drug transport route/mechanisms from nasal mucosa to the brain, and targeted area/cells (neuron, microglia, astrocyte, etc.) in the brain suitable for targeted CNS disorders.

Dr. Takanori Kanazawa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nose-to-brain
  • drug delivery system
  • nanocarrier
  • central nervous system disorders
  • lipid-based nanoparticles
  • polymer-based nanoparticles
  • nasal mucosa
  • targeting
  • neuron
  • microglia
  • astrocyte

Published Papers (1 paper)

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Research

19 pages, 5269 KiB  
Article
Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study
by Xiuhua April Si, Muhammad Sami and Jinxiang Xi
Pharmaceutics 2021, 13(6), 903; https://doi.org/10.3390/pharmaceutics13060903 - 18 Jun 2021
Cited by 11 | Viewed by 4354
Abstract
Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often suffered from a lack of quantitative dosimetry in the target region, which relied on the observer’s subjective perception of [...] Read more.
Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often suffered from a lack of quantitative dosimetry in the target region, which relied on the observer’s subjective perception of color changes in the endoscopy images. The objective of this study is to test the feasibility of gravitationally driven droplet translocation numerically to enhance the nasal spray dosages in the olfactory region and quantify the intranasal dose distribution in the regions of interest. A computational nasal spray testing platform was developed that included a nasal spray releasing model, an airflow-droplet transport model, and an Eulerian wall film formation/translocation model. The effects of both device-related and administration-related variables on the initial olfactory deposition were studied, including droplet size, velocity, plume angle, spray release position, and orientation. The liquid film formation and translocation after nasal spray applications were simulated for both a standard and a newly proposed delivery system. Results show that the initial droplet deposition in the olfactory region is highly sensitive to the spray plume angle. For the given nasal cavity with a vertex-to-floor head position, a plume angle of 10° with a device orientation of 45° to the nostril delivered the optimal dose to the olfactory region. Liquid wall film translocation enhanced the olfactory dosage by ninefold, compared to the initial olfactory dose, for both the baseline and optimized delivery systems. The optimized delivery system delivered 6.2% of applied sprays to the olfactory region and significantly reduced drug losses in the vestibule. Rheological properties of spray formulations can be explored to harness further the benefits of liquid film translocation in targeted intranasal deliveries. Full article
(This article belongs to the Special Issue Nose-To-Brain Drug Delivery System)
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