Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Recent Advances in Metal-Organic Materials for Drug Delivery
share announcement

Recent Advances in Metal-Organic Materials for Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 7179

Special Issue Editors

Dr. Rosario Mercedes Pérez Colodrero

E-Mail Website
Guest Editor
Dpto Química Inorgánica, Cristalografía y Mineralogía. Facultad de Ciencias. Universidad de Málaga, 29071 Málaga, Spain
Interests: metal phosphonates; coordination polymers; proton conductivity; composite membrane; PEMFCs; electrocatalyst
Special Issues, Collections and Topics in MDPI journals
Dr. Konstantinos E. Papathanasiou

E-Mail Website
Guest Editor
1. Faculty of Sciences & Engineering, University of Wolverhampton, Wolerhampton WV1 1LY, UK
2. International Laboratory of Nanochemistry and Ecology, National University of Science and Technology MISiS, Moscow, Leninsky Prosp. 4, 119991 Moscow, Russia
Interests: metal-organic frameworks; MOF; metal-phosphonates; metal-nanoparticles; controlled release; hydrogels; silica gels; crystal growth

Special Issue Information

Dear Colleagues,

Tremendous scientific efforts have been dedicated to expanding the field of controlled drug release so far. The majority of the studied materials exhibit poor performance due to poor loadings of the pharmaceutical agent. Apart from that, intermolecular interactions dictate release phenomena, and, as a result, controlling the release of the drugs remains a big challenge. In the last two decades, novel, porous hybrid materials have shown their ability to host pharmaceutical agents due to their porosity. Materials with tuneable frameworks and/or functionalized cavities show promising results in better drug-interaction and loadings. More specifically, metal-organic materials can be possible candidates, as they can act as carriers and pharmaceutics simultaneously. In this regard, we cordially welcome the researchers working in the field to submit their contributions on the aspects mentioned above or other topics relevant to the theme. Original research articles, reviews, letters, and communications are suitable submissions.

Dr. Rosario Mercedes Pérez Colodrero
Dr. Konstantinos E. Papathanasiou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal-organic frameworks
  • materials
  • controlled-release
  • metal-nanoparticles
  • metals
  • drug delivery
  • porous
  • pharmaceutical

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

18 pages, 4109 KiB  
Article
Iron-Gallic Acid Peptide Nanoparticles as a Versatile Platform for Cellular Delivery with Synergistic ROS Enhancement Effect
by Faqian Shen, Yi Lin, Miriam Höhn, Xianjin Luo, Markus Döblinger, Ernst Wagner and Ulrich Lächelt
Pharmaceutics 2023, 15(7), 1789; https://doi.org/10.3390/pharmaceutics15071789 - 21 Jun 2023
Cited by 1 | Viewed by 1280
Abstract
Cytosolic delivery of peptides is of great interest owing to their biological functions, which could be utilized for therapeutic applications. However, their susceptibility to enzymatic degradation and multiple cellular barriers generally hinders their clinical application. Integration into nanoparticles, which can enhance the stability [...] Read more.
Cytosolic delivery of peptides is of great interest owing to their biological functions, which could be utilized for therapeutic applications. However, their susceptibility to enzymatic degradation and multiple cellular barriers generally hinders their clinical application. Integration into nanoparticles, which can enhance the stability and membrane permeability of bioactive peptides, is a promising strategy to overcome extracellular and intracellular obstacles. Herein, we present a versatile platform for the cellular delivery of various cargo peptides by integration into metallo-peptidic coordination nanoparticles. Both termini of cargo peptides were conjugated with gallic acid (GA) to assemble GA-modified peptides into nanostructures upon coordination of Fe(III). Initial pre-complexation of Fe(III) by poly-(vinylpolypyrrolidon) (PVP) as a template favored the formation of nanoparticles, which are able to deliver the peptides into cells efficiently. Iron–gallic acid peptide nanoparticles (IGPNs) are stable in water and are supposed to generate reactive oxygen species (ROS) from endogenous H2O2 in cells via the Fenton reaction. The strategy was successfully applied to an exemplary set of peptide sequences varying in length (1–7 amino acids) and charge (negative, neutral, positive). To confirm the capability of transporting bioactive cargos into cells, pro-apoptotic peptides were integrated into IGPNs, which demonstrated potent killing of human cervix carcinoma HeLa and murine neuroblastoma N2a cells at a 10 µM peptide concentration via the complementary mechanisms of peptide-triggered apoptosis and Fe(III)-mediated ROS generation. This study demonstrates the establishment of IGPNs as a novel and versatile platform for the assembly of peptides into nanoparticles, which can be used for cellular delivery of bioactive peptides combined with intrinsic ROS generation. Full article
(This article belongs to the Special Issue Recent Advances in Metal-Organic Materials for Drug Delivery)
►▼ Show Figures

Figure 1

18 pages, 4176 KiB  
Article
Development of Copper Complexes with Diimines and Dipicolinate as Anticancer Cytotoxic Agents
by Natalia Alvarez, Analu Rocha, Victoria Collazo, Javier Ellena, Antonio J. Costa-Filho, Alzir A. Batista and Gianella Facchin
Pharmaceutics 2023, 15(5), 1345; https://doi.org/10.3390/pharmaceutics15051345 - 27 Apr 2023
Cited by 3 | Viewed by 1549
Abstract
Coordination complexes may act as anticancer agents. Among others, the formation of the complex may facilitate the ligand uptake by the cell. Searching for new copper compounds with cytotoxic activity, the complex Cu-dipicolinate was studied as a neutral scaffold to form ternary complexes [...] Read more.
Coordination complexes may act as anticancer agents. Among others, the formation of the complex may facilitate the ligand uptake by the cell. Searching for new copper compounds with cytotoxic activity, the complex Cu-dipicolinate was studied as a neutral scaffold to form ternary complexes with diimines. A series of [Cu(dipicolinate)(diimine)] complexes (where diimine: Phenanthroline, phen, 5-NO2-phenanthroline, 4-methyl-phenanthroline, neocuproine, 3,4,7,8-tetramethyl-phenanthroline, tmp, bathophenanthroline, bipyridine, dimethyl-bipyridine, as well as the ligand 2,2-dipyridil-amine, bam) were synthesized and characterized both in the solid state, including a new crystal structure of [Cu2(dipicolinate)2(tmp)2]·7H2O. Their chemistry in aqueous solution was explored by UV/vis spectroscopy, conductivity, cyclic voltammetry, and electron paramagnetic resonance studies. Their DNA binding was analyzed by electronic spectroscopy (determining Kb values), circular dichroism, and viscosity methods. The cytotoxicity of the complexes was assessed on human cancer cell lines MDA-MB-231, MCF-7 (breast, the first triple negative), A549 (lung epithelial) and A2780cis (ovarian, Cisplatin-resistant), and non-tumor cell lines MRC-5 (lung) and MCF-10A (breast). The major species are ternary, in solution and solid state. Complexes are highly cytotoxic as compared to Cisplatin. Complexes containing bam and phen are interesting candidates to study their in vivo activity in triple-negative breast cancer treatment. Full article
(This article belongs to the Special Issue Recent Advances in Metal-Organic Materials for Drug Delivery)
►▼ Show Figures

Graphical abstract

21 pages, 4540 KiB  
Article
Pt(II)-PLGA Hybrid in a pH-Responsive Nanoparticle System Targeting Ovarian Cancer
by Marek T. Wlodarczyk, Sylwia A. Dragulska, Ying Chen, Mina Poursharifi, Maxier Acosta Santiago, John A. Martignetti and Aneta J. Mieszawska
Pharmaceutics 2023, 15(2), 607; https://doi.org/10.3390/pharmaceutics15020607 - 10 Feb 2023
Cited by 3 | Viewed by 2152
Abstract
Platinum-based agents are the main treatment option in ovarian cancer (OC). Herein, we report a poly(lactic-co-glycolic acid) (PLGA) nanoparticle (NP) encapsulating platinum (II), which is targeted to a cell-spanning protein overexpressed in above 90% of late-stage OC, mucin 1 (MUC1). The NP is [...] Read more.
Platinum-based agents are the main treatment option in ovarian cancer (OC). Herein, we report a poly(lactic-co-glycolic acid) (PLGA) nanoparticle (NP) encapsulating platinum (II), which is targeted to a cell-spanning protein overexpressed in above 90% of late-stage OC, mucin 1 (MUC1). The NP is coated with phospholipid-DNA aptamers against MUC1 and a pH-sensitive PEG derivative containing an acid-labile hydrazone linkage. The pH-sensitive PEG serves as an off–on switch that provides shielding effects at the physiological pH and is shed at lower pH, thus exposing the MUC1 ligands. The pH-MUC1-Pt NPs are stable in the serum and display pH-dependent PEG cleavage and drug release. Moreover, the NPs effectively internalize in OC cells with higher accumulation at lower pH. The Pt (II) loading into the NP was accomplished via PLGA-Pt (II) coordination chemistry and was found to be 1.62 wt.%. In vitro screening using a panel of OC cell lines revealed that pH-MUC1-Pt NP has a greater effect in reducing cellular viability than carboplatin, a clinically relevant drug analogue. Biodistribution studies have demonstrated NP accumulation at tumor sites with effective Pt (II) delivery. Together, these results demonstrate a potential for pH-MUC1-Pt NP for the enhanced Pt (II) therapy of OC and other solid tumors currently treated with platinum agents. Full article
(This article belongs to the Special Issue Recent Advances in Metal-Organic Materials for Drug Delivery)
►▼ Show Figures

Figure 1

14 pages, 2258 KiB  
Article
Antitumoral and Antimicrobial Activities of Block Copolymer Micelles Containing Gold Bisdithiolate Complexes
by Andreia Sousa, Joana F. Santos, Francisco Silva, Sílvia A. Sousa, Jorge H. Leitão, António P. Matos, Teresa Pinheiro, Rafaela A. L. Silva, Dulce Belo, Manuel Almeida, Fernanda Marques and Célia Fernandes
Pharmaceutics 2023, 15(2), 564; https://doi.org/10.3390/pharmaceutics15020564 - 08 Feb 2023
Cited by 3 | Viewed by 1732
Abstract
Gold(III) bisdithiolate complexes have been reported as potential antimicrobial and antitumoral agents. The complex [Au(cdc)2]− (cdc=cyanodithioimido carbonate) displayed antimicrobial and outstanding antitumor activity against the ovarian cancer cells A2780 and A2780cisR, which are sensitive and resistant to cisplatin, respectively. However, [...] Read more.
Gold(III) bisdithiolate complexes have been reported as potential antimicrobial and antitumoral agents. The complex [Au(cdc)2]− (cdc=cyanodithioimido carbonate) displayed antimicrobial and outstanding antitumor activity against the ovarian cancer cells A2780 and A2780cisR, which are sensitive and resistant to cisplatin, respectively. However, poor water solubility may hamper its clinical use. Block copolymer micelles (BCMs) may solubilize hydrophobic drugs, improving their bioavailability and circulation time in blood. Aiming to provide water solubility, prolonged availability, and enhanced therapeutic indexes, BCMs loaded with [Au(cdc)2]− were synthesized and characterized. The BCM-[Au(cdc)2] micelles were prepared with a loading efficiency of 64.6% and a loading content of 35.3 mg [Au(cdc)2]−/gBCM. A hydrodynamic diameter of 77.31 ± 27.00 nm and a low polydispersity index of 0.18 indicated that the micelles were homogenous and good candidates for drug delivery. Cytotoxic activity studies against A2780/A2780cisR cells showed that BCM-[Au(cdc)2] maintained relevant cytotoxic activity comparable to the cytotoxicity observed for the same concentration of gold complexes. The Au uptake in A2780 cells, determined by PIXE, was ca. 17% higher for BCMs-[Au(cdc)2] compared to [Au(cdc)2]−. The BCMs-[Au(cdc)2] presented antimicrobial activity against S. aureus Newman and C. glabrata CBS138. These results evidenced the potential of BCM-[Au(cdc)2] for drug delivery and its promising anticancer and antimicrobial activities. Full article
(This article belongs to the Special Issue Recent Advances in Metal-Organic Materials for Drug Delivery)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop