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Pharmaceutics
Special Issues
Metal-Based Nanoparticles for Pharmaceutical Applications
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Metal-Based Nanoparticles for Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 6489

Special Issue Editors

Dr. Elisa Panzarini

E-Mail Website
Guest Editor
Department of Biological Sciences and Technologies (Di.S.Te.B.A.), Laboratory of Comparative Anatomy and Cytology, University of Salento, 73100 Lecce, Italy
Interests: extracellular vesicles; differentiation; neuroinflammation; apoptosis; autophagy; nanotoxicology; drug delivery; cancer therapy; neurodegenerative diseases; nanoparticles
Special Issues, Collections and Topics in MDPI journals
Dr. Stefania Mariano

E-Mail Website
Guest Editor
Department of Biological Sciences and Technologies (Di.S.Te.B.A.), Laboratory of Comparative Anatomy and Cytology, University of Salento, 73100 Lecce, Italy
Interests: nanotoxicology; nanoplastics; microplastics; nanomaterials; nano-biointeraction; drug delivery; nanosafety; ecotoxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metal-based nanoparticles (MNPs) stand out as nanotechnological solutions for a wide range of open biological and medical physio/pathological questions in biomedicine.

Their optical, magnetic, and electrical activities make them very important as nanoparticle-based image tools to be used in early diagnoses; furthermore, their capability to generate reactive oxygen species (ROS), possessing multiple biological functions in health and disease, suggests their potential exploitation for the development of new therapies. Finally, their potential use as theranostic agents could result in great and exciting progressions for personalized medicine.

This Special Issue aims to collect manuscripts from all scientists producing and/or applying metal nanoparticles in a diagnostic, therapeutic, or theranostics context, providing an insight into the latest advances in the field of nanomedicine with emphasis on the benefits, limitations, and future directions of utilizing metal nanoparticles in pharmaceutical applications. Original research papers and review articles are warmly welcomed.

Dr. Elisa Panzarini
Dr. Stefania Mariano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal-based nanoparticles
  • theranostics
  • bioimaging
  • cancer therapy
  • drug delivery systems
  • nanomedicine
  • cell death
  • nanotoxicology

Published Papers (3 papers)

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Research

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14 pages, 3915 KiB  
Article
Amphotericin B-PEG Conjugates of ZnO Nanoparticles: Enhancement Antifungal Activity with Minimal Toxicity
by Saad M. Alshahrani, El-Sayed Khafagy, Yassine Riadi, Ahmed Al Saqr, Munerah M. Alfadhel and Wael A. H. Hegazy
Pharmaceutics 2022, 14(8), 1646; https://doi.org/10.3390/pharmaceutics14081646 - 07 Aug 2022
Cited by 16 | Viewed by 1593
Abstract
Amphotericin B (AMB) is commonly used to treat life-threatening systemic fungal infections. AMB formulations that are more efficient and less nephrotoxic are currently unmet needs. In the current study, new ZnO-PEGylated AMB (ZnO-AMB-PEG) nanoparticles (NPs) were synthesized and their antifungal effects on the [...] Read more.
Amphotericin B (AMB) is commonly used to treat life-threatening systemic fungal infections. AMB formulations that are more efficient and less nephrotoxic are currently unmet needs. In the current study, new ZnO-PEGylated AMB (ZnO-AMB-PEG) nanoparticles (NPs) were synthesized and their antifungal effects on the Candida spp. were investigated. The size and zeta potential values of AMB-PEG and ZnO-AMB-PEG NPs were 216.2 ± 26.9 to 662.3 ± 24.7 nm and −11.8 ± 2.02 to −14.2 ± 0.94 mV, respectively. The FTIR, XRD, and EDX spectra indicated that the PEG-enclosed AMB was capped by ZnO, and SEM images revealed the ZnO distribution on the surface NPs. In comparison to ZnO-AMB NPs and free AMB against C.albicans and C.neoformans, ZnO-AMB-PEG NPs significantly reduced the MIC and MFC. After a week of single and multiple dosage, the toxicity was investigated utilizing in vitro blood hemolysis, in vivo nephrotoxicity, and hepatic functions. ZnO-AMB-PEG significantly lowered WBC count and hematocrit concentrations when compared to AMB and ZnO-AMB. RBC count and hemoglobulin content, on the other hand, were unaltered. ZnO-AMB-PEG considerably lowered creatinine and blood urea nitrogen (BUN) levels when compared to AMB and ZnO-AMB. The difference in liver function indicators was determined to be minor by all formulae. These findings imply that ZnO-AMB-PEG could be utilized in the clinic with little nephrotoxicity, although more research is needed to determine the formulation’s in vivo efficacy. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles for Pharmaceutical Applications)
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Review

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34 pages, 11203 KiB  
Review
Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques
by Simona Tarantino, Anna Paola Caricato, Rosaria Rinaldi, Caterina Capomolla and Valeria De Matteis
Pharmaceutics 2023, 15(2), 500; https://doi.org/10.3390/pharmaceutics15020500 - 02 Feb 2023
Cited by 4 | Viewed by 1748
Abstract
The conventional methods of cancer treatment and diagnosis, such as radiotherapy, chemotherapy, and computed tomography, have developed a great deal. However, the effectiveness of such methods is limited to the possible failure or collateral effects on the patients. In recent years, nanoscale materials [...] Read more.
The conventional methods of cancer treatment and diagnosis, such as radiotherapy, chemotherapy, and computed tomography, have developed a great deal. However, the effectiveness of such methods is limited to the possible failure or collateral effects on the patients. In recent years, nanoscale materials have been studied in the field of medical physics to develop increasingly efficient methods to treat diseases. Gold nanoparticles (AuNPs), thanks to their unique physicochemical and optical properties, were introduced to medicine to promote highly effective treatments. Several studies have confirmed the advantages of AuNPs such as their biocompatibility and the possibility to tune their shapes and sizes or modify their surfaces using different chemical compounds. In this review, the main properties of AuNPs are analyzed, with particular focus on star-shaped AuNPs. In addition, the main methods of tumor treatment and diagnosis involving AuNPs are reviewed. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles for Pharmaceutical Applications)
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21 pages, 4725 KiB  
Review
Inorganic Nanoflowers—Synthetic Strategies and Physicochemical Properties for Biomedical Applications: A Review
by Su Jung Lee, Hongje Jang and Do Nam Lee
Pharmaceutics 2022, 14(9), 1887; https://doi.org/10.3390/pharmaceutics14091887 - 06 Sep 2022
Cited by 5 | Viewed by 2562
Abstract
Nanoflowers, which are flower-shaped nanomaterials, have attracted significant attention from scientists due to their unique morphologies, facile synthetic methods, and physicochemical properties such as a high surface-to-volume ratio, enhanced charge transfer and carrier immobility, and an increased surface reaction efficiency. Nanoflowers can be [...] Read more.
Nanoflowers, which are flower-shaped nanomaterials, have attracted significant attention from scientists due to their unique morphologies, facile synthetic methods, and physicochemical properties such as a high surface-to-volume ratio, enhanced charge transfer and carrier immobility, and an increased surface reaction efficiency. Nanoflowers can be synthesized using inorganic or organic materials, or a combination of both (called a hybrid), and are mainly used for biomedical applications. Thus far, researchers have focused on hybrid nanoflowers and only a few studies on inorganic nanoflowers have been reported. For the first time in the literature, we have consolidated all the reports on the biomedical applications of inorganic nanoflowers in this review. Herein, we review some important inorganic nanoflowers, which have applications in antibacterial treatment, wound healing, combinatorial cancer therapy, drug delivery, and biosensors to detect diseased conditions such as diabetes, amyloidosis, and hydrogen peroxide poisoning. In addition, we discuss the recent advances in their biomedical applications and preparation methods. Finally, we provide a perspective on the current trends and potential future directions in nanoflower research. The development of inorganic nanoflowers for biomedical applications has been limited to date. Therefore, a diverse range of nanoflowers comprising inorganic elements and materials with composite structures must be synthesized using ecofriendly synthetic strategies. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles for Pharmaceutical Applications)
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