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Pharmaceutics
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Enhancement for Strategies in Liposomal and Niosomal Preparations: Formulative and...
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Enhancement for Strategies in Liposomal and Niosomal Preparations: Formulative and Technological Innovations

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 5052

Special Issue Editors

Dr. Anna Angela Barba

E-Mail Website
Guest Editor
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy
Interests: drug delivery systems; sustainable process; process intensification; micro/nano fabrication techniques; liposomes production; hydrogels
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Gaetano Lamberti

E-Mail Website
Guest Editor
Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy
Interests: hydrogels; drug delivery; modeling; liposomes; nanoparticles
Special Issues, Collections and Topics in MDPI journals
Dr. Diego Caccavo

E-Mail Website
Guest Editor
Department of Industrial Engineering, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy
Interests: drug delivery systems; liposomes production; hydrogels; pharmacokinetic/pharmacodynamic modeling

Special Issue Information

Dear Colleagues,

Currently, industrial pharmaceutical/nutraceutical manufacturing has to comply with two major needs: the mandatory regulations for formulation safety and the sustainability of production. Within this framework, the role of scientific research into more powerful drug delivery systems appears to be highly relevant because it can give responses to the industry about both the formulative and preparative issues.

Lipid-based drug delivery systems are recognized as safe and effective carriers. The different classes of liposomal and niosomal vesicles are the main expression of delivery systems for which formulation and preparation can be easily tailored to meet different disease conditions, routes of administration, structures (coated, functionalized, stealth) and size s(micro-nano), stabilities, and costs.

This Special Issue aims to collect cutting-edge research results on liposomes and niosomes that have been achieved through both formulative and preparative new approaches, with the aim of moving towards advanced technologies for pharmaceutical manufacturing. A key point of this Special Issue is to connect multidisciplinary competences in drug membrane-mimetic delivery systems.

We are pleased to invite you to share your results contributing to how we can resolve the above-introduced pharmaceutic production needs. In this Special Issue, original research articles and reviews are welcome.

Research areas may include (but are not limited to) the following:

  • New liposomal/niosomal new formulations;
  • Liposomal/niosomal production using innovative strategies;
  • In vitro, in vivo, and ex vivo testing of liposomes/niosomes ;
  • Liposomes/niosomes coating/functionalization;
  • Hybrid lipid-based drug delivery systems;
  • Enhanced stability of liposomal/niosomal production;
  • Modeling of assembled lipid vesicles phenomena;
  • Pharmacokinetic/pharmacodynamic modeling of drug release from liposomal/niosomal carriers.

We look forward to receiving your contributions.

Prof. Dr. Anna Angela Barba
Prof. Dr. Gaetano Lamberti
Dr. Diego Caccavo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • liposomes
  • niosomes
  • formulation development
  •  lipid vesicles
  • nano/microcarriers
  • coating
  • drug encapsulation
  • sustainable processes
  • process intensification

Published Papers (2 papers)

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Research

17 pages, 2859 KiB  
Article
Establishment of an Antiplasmodial Vaccine Based on PfRH5-Encoding RNA Replicons Stabilized by Cationic Liposomes
by Wesley L. Fotoran, Jamile Ramos da Silva, Christiane Glitz, Luís Carlos de Souza Ferreira and Gerhard Wunderlich
Pharmaceutics 2023, 15(4), 1223; https://doi.org/10.3390/pharmaceutics15041223 - 12 Apr 2023
Cited by 2 | Viewed by 1968
Abstract
Background: Nucleic acid-based vaccines have been studied for the past four decades, but the approval of the first messenger RNA (mRNA) vaccines during the COVID-19 pandemic opened renewed perspectives for the development of similar vaccines against different infectious diseases. Presently available mRNA vaccines [...] Read more.
Background: Nucleic acid-based vaccines have been studied for the past four decades, but the approval of the first messenger RNA (mRNA) vaccines during the COVID-19 pandemic opened renewed perspectives for the development of similar vaccines against different infectious diseases. Presently available mRNA vaccines are based on non-replicative mRNA, which contains modified nucleosides encased in lipid vesicles, allowing for entry into the host cell cytoplasm, and reducing inflammatory reactions. An alternative immunization strategy employs self-amplifying mRNA (samRNA) derived from alphaviruses, but lacks viral structural genes. Once incorporated into ionizable lipid shells, these vaccines lead to enhanced gene expression, and lower mRNA doses are required to induce protective immune responses. In the present study, we tested a samRNA vaccine formulation based on the SP6 Venezuelan equine encephalitis (VEE) vector incorporated into cationic liposomes (dimethyldioctadecyl ammonium bromide and a cholesterol derivative). Three vaccines were generated that encoded two reporter genes (GFP and nanoLuc) and the Plasmodium falciparum reticulocyte binding protein homologue 5 (PfRH5). Methods: Transfection assays were performed using Vero and HEK293T cells, and the mice were immunized via the intradermal route using a tattooing device. Results: The liposome–replicon complexes showed high transfection efficiencies with in vitro cultured cells, whereas tattooing immunization with GFP-encoding replicons demonstrated gene expression in mouse skin up to 48 h after immunization. Mice immunized with liposomal PfRH5-encoding RNA replicons elicited antibodies that recognized the native protein expressed in P. falciparum schizont extracts, and inhibited the growth of the parasite in vitro. Conclusion: Intradermal delivery of cationic lipid-encapsulated samRNA constructs is a feasible approach for developing future malaria vaccines. Full article
(This article belongs to the Special Issue Enhancement for Strategies in Liposomal and Niosomal Preparations: Formulative and Technological Innovations)
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18 pages, 2214 KiB  
Article
A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems
by Raffaella De Piano, Diego Caccavo, Gaetano Lamberti, Katrien Remaut, Hanne Seynaeve and Anna Angela Barba
Pharmaceutics 2023, 15(3), 959; https://doi.org/10.3390/pharmaceutics15030959 - 16 Mar 2023
Cited by 3 | Viewed by 1672
Abstract
The use of natural resources and the enhancing of technologies are outlining the strategies of modern scientific-technological research for sustainable health products manufacturing. In this context, the novel simil-microfluidic technology, a mild production methodology, is exploited to produce liposomal curcumin as potential powerful [...] Read more.
The use of natural resources and the enhancing of technologies are outlining the strategies of modern scientific-technological research for sustainable health products manufacturing. In this context, the novel simil-microfluidic technology, a mild production methodology, is exploited to produce liposomal curcumin as potential powerful dosage system for cancer therapies and for nutraceutical purposes. Through simil-microfluidic technology, based on interdiffusion phenomena of a lipid-ethanol phase in an aqueous flow, massive productions of liposomes at nanometric scale can be obtained. In this work, studies on liposomal production with useful curcumin loads were performed. In particular, process issues (curcumin aggregations) were elucidated and formulation optimization for curcumin load was performed. The main achieved result has been the definition of operative conditions for nanoliposomal curcumin production with interesting loads and encapsulation efficiencies. Full article
(This article belongs to the Special Issue Enhancement for Strategies in Liposomal and Niosomal Preparations: Formulative and Technological Innovations)
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