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Pharmaceutics
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Chitosan Nanoparticles in Drug Delivery 2022
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Chitosan Nanoparticles in Drug Delivery 2022

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (10 June 2023) | Viewed by 7338

Special Issue Editor

Dr. Ellen Wasan

E-Mail Website
Guest Editor
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
Interests: lipid-based drug delivery; lipid nanoparticles; polymer nanoparticles; vaccine adjuvants; immunology; oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chitosan is a polysaccharide derived through the deacetylation of the naturally occurring polymer chitin, which occurs in crustacean shells. Chitosan is widely available commercially in various forms, and its chemistry lends itself to functionalization. Due to its excellent biocompatibility, biodegradability and versatility, chitosan has been applied to diverse drug delivery systems for nearly every route of administration. The close relationship between the physical properties of the specific chitosan polymer used and its performance in drug delivery systems requires that we gain a further understanding not only of advanced fabrication methodologies and key physical characterization parameters, but also of biological interactions with chitosan at the cellular and systems levels. This Special Issue of Pharmaceutics plans to provide readers an overview and considerable depth on the current state of chitosan nanoparticle technology, application and analysis.

Dr. Ellen Wasan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticle fabrication
  • nanoparticle characterization
  • nanoparticle toxicology
  • controlled drug release
  • smart polymers
  • biocompatibility
  • targeted drug delivery
  • gene therapy
  • theranostics

Related Special Issue

Published Papers (3 papers)

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Research

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16 pages, 4583 KiB  
Article
Synergistic Effect of Thermoresponsive and Photocuring Methacrylated Chitosan-Based Hybrid Hydrogels for Medical Applications
by Chun-Cheng Chen, Jie-Mao Wang, Yun-Ru Huang, Yi-Hsuan Yu, Tzong-Ming Wu and Shinn-Jyh Ding
Pharmaceutics 2023, 15(4), 1090; https://doi.org/10.3390/pharmaceutics15041090 - 29 Mar 2023
Cited by 4 | Viewed by 1337
Abstract
The thermoresponsive drug-loaded hydrogels have attracted widespread interest in the field of medical applications due to their ease of delivery to structurally complex tissue defects. However, drug-resistant infections remain a challenge, which has prompted the development of new non-antibiotic hydrogels. To this end, [...] Read more.
The thermoresponsive drug-loaded hydrogels have attracted widespread interest in the field of medical applications due to their ease of delivery to structurally complex tissue defects. However, drug-resistant infections remain a challenge, which has prompted the development of new non-antibiotic hydrogels. To this end, we prepared chitosan-methacrylate (CTSMA)/gelatin (GEL) thermoresponsive hydrogels and added natural phenolic compounds, including tannic acid, gallic acid, and pyrogallol, to improve the efficacy of hydrogels. This hybrid hydrogel imparted initial crosslinking at physiological temperature, followed by photocuring to further provide a mechanically robust structure. Rheological analysis, tensile strength, antibacterial activity against E. coli, S. aureus, P. gingivalis, and S. mutans, and L929 cytotoxicity were evaluated. The experimental results showed that the hybrid hydrogel with CTSMA/GEL ratio of 5/1 and tannic acid additive had a promising gelation temperature of about 37 °C. The presence of phenolic compounds not only significantly (p < 0.05) enhanced cell viability, but also increased the tensile strength of CTSMA/GEL hybrid hydrogels. Moreover, the hydrogel containing tannic acid revealed potent antibacterial efficacy against four microorganisms. It was concluded that the hybrid hydrogel containing tannic acid could be a potential composite material for medical applications. Full article
(This article belongs to the Special Issue Chitosan Nanoparticles in Drug Delivery 2022)
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13 pages, 4989 KiB  
Article
Enhancement of Storage Stability and Masking Effect of Curcumin by Turmeric Extract-Loaded Nanoemulsion and Water-Soluble Chitosan Coating
by Bom Nae Lee, Su Jung Hong, Mi Hee Yu, Gye Hwa Shin and Jun Tae Kim
Pharmaceutics 2022, 14(8), 1547; https://doi.org/10.3390/pharmaceutics14081547 - 25 Jul 2022
Cited by 4 | Viewed by 2100
Abstract
This study focused on improving curcumin stability in various pHs and NaCl concentrations and reducing the strong scent of turmeric by the nanoemulsions system and further coating with water-soluble chitosan (WSC). Turmeric extract-loaded nanoemulsions (TE-NEs) were firstly prepared by mixing an oil phase [...] Read more.
This study focused on improving curcumin stability in various pHs and NaCl concentrations and reducing the strong scent of turmeric by the nanoemulsions system and further coating with water-soluble chitosan (WSC). Turmeric extract-loaded nanoemulsions (TE-NEs) were firstly prepared by mixing an oil phase containing turmeric extract, MCT oil, and lecithin, and an aqueous phase containing tween 80 using an ultrasonication method. TE-NEs were further coated with WSC in the ratio of TE-NEs and WSC (1:1 to 1:10). The optimum WSC-TE-NEs exhibited an average particle size of 182 nm, a PDI of 0.317, and a zeta potential of +30.42 mV when WSC-TE-NEs were prepared in the ratio of 1:1. The stability of the WSC-TE-NEs was also assessed by determining the remained curcumin content. The remained curcumin contents of the TE-NEs and the WSC-TE-NEs were higher than that of the turmeric extract (TE) at pH 2~7 and NaCl concentrations of 100~400 mM. Fourier transform infrared (FT-IR) spectra, transmission electron microscope (TEM), and confocal laser scanning microscope (CLSM) images confirmed that the TE-NEs were successfully encapsulated with a WSC coating. As a result of GC analysis, the content of aromatic-turmerone was significantly decreased in the TE-NEs and the WSC-TE-NEs compared to the pristine TE, but there was no significant difference between the TE-NEs and the WSC-TE-NEs. These results suggest that water-soluble chitosan-coated nanoemulsions may be suitable for improving the chemical stability and masking effect of curcumin to facilitate its application in food. Full article
(This article belongs to the Special Issue Chitosan Nanoparticles in Drug Delivery 2022)
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Review

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26 pages, 4092 KiB  
Review
Chitosans and Nanochitosans: Recent Advances in Skin Protection, Regeneration, and Repair
by Patricia Garcia Ferreira, Vitor Francisco Ferreira, Fernando de Carvalho da Silva, Cyntia Silva Freitas, Patricia Ribeiro Pereira and Vania Margaret Flosi Paschoalin
Pharmaceutics 2022, 14(6), 1307; https://doi.org/10.3390/pharmaceutics14061307 - 20 Jun 2022
Cited by 21 | Viewed by 3066
Abstract
Chitosan displays a dual function, acting as both an active ingredient and/or carrier for pharmaceutical bioactive molecules and metal ions. Its hydroxyl- and amino-reactive groups and acetylation degree can be used to adjust this biopolymer’s physicochemical and pharmacological properties in different forms, including [...] Read more.
Chitosan displays a dual function, acting as both an active ingredient and/or carrier for pharmaceutical bioactive molecules and metal ions. Its hydroxyl- and amino-reactive groups and acetylation degree can be used to adjust this biopolymer’s physicochemical and pharmacological properties in different forms, including scaffolds, nanoparticles, fibers, sponges, films, and hydrogels, among others. In terms of pharmacological purposes, chitosan association with different polymers and the immobilization or entrapment of bioactive agents are effective strategies to achieve desired biological responses. Chitosan biocompatibility, water entrapment within nanofibrils, antioxidant character, and antimicrobial and anti-inflammatory properties, whether enhanced by other active components or not, ensure skin moisturization, as well as protection against bacteria colonization and oxidative imbalance. Chitosan-based nanomaterials can maintain or reconstruct skin architecture through topical or systemic delivery of hydrophilic or hydrophobic pharmaceuticals at controlled rates to treat skin affections, such as acne, inflammatory manifestations, wounds, or even tumorigenesis, by coating chemotherapy drugs. Herein, chitosan obtention, physicochemical characteristics, chemical modifications, and interactions with bioactive agents are presented and discussed. Molecular mechanisms involved in chitosan skin protection and recovery are highlighted by overlapping the events orchestrated by the signaling molecules secreted by different cell types to reconstitute healthy skin tissue structures and components. Full article
(This article belongs to the Special Issue Chitosan Nanoparticles in Drug Delivery 2022)
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