Novel Cell and Bioinspired Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 January 2024) | Viewed by 3974

Special Issue Editors


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Guest Editor
1. Department of Pharmaceutical Sciences, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Salamanca, Salamanca, Spain
2. Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
Interests: erythrocytes; drug delivery; cell-based platforms; nanoparticles; exosomes
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Pharmaceutical Sciences, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Salamanca, Salamanca, Spain
2. Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
Interests: controlled drug delivery; nanoparticles; cell-based drug delivery; antiinfective therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our new Special Issue entitled Novel Cell and Bioinspired Drug Delivery Systems.

The development of delivery systems capable of specific drug targeting while ensuring stability and tolerability is still a challenge. Carriers of natural origin have emerged as alternatives to synthetic formulations due to their advantages such as biocompatibility, biodegradability, and targeting abilities. Among them, whole cells and, more recently, cell-derived extracellular vesicles (EVs) have been proposed as drug carriers. These allow the vectorization of the incorporated therapeutic molecules due to their intrinsic properties and additional functions. Additionally, in order to combine the advantages of natural cells and synthetic polymers, membrane-coated nanoparticles and synthetic biomimetic systems have emerged as novel delivery strategies. Despite their promising potential, research into efficient manufacturing and quality-control techniques is needed to develop clinical therapeutic strategies based on these carriers.

This Special Issue aims to provide an overview of state-of-the-art and recent trends in cell-based drug delivery system research. It will also include cell-based derivatives such as exosomes and synthetic nanoparticles camouflaged with cell membranes. Finally, synthetic vehicles that mimic those of natural origin for drug delivery will also be considered.

In light of your expertise in the field and wide research interests, we are convinced that your work could make an excellent contribution to this Special Issue.

Original research articles and reviews are both welcome. Research areas may include, but are by no means limited to, the following:

  • Cell-based platforms with therapeutic or theranostic applications;
  • Cell-based platform applications in cancer therapy;
  • Cell-derived systems for drug delivery;
  • Nanoparticle-loaded cell-based systems;
  • Artificial cell applications for drug delivery;
  • Biomimetic synthetic/hybrid systems for drug delivery;
  • Cell-mimicking particles for drug delivery;
  • Applications of cell-derived vesicles in drug delivery;
  • Erythrocytes for drug delivery;     
  • Stem cell drug delivery systems;
  • Dendritic cells in drug delivery;
  • Bacterial ghosts as drug carriers;
  • Nanoparticles coated with cell membranes;
  • Applications of exosomes in drug delivery.

We look forward to receiving your contributions.

Dr. Carmen Gutierez-Millan
Dr. Clara Isabel Colino Gandarillas
Guest Editors

Manuscript Submission Information

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Keywords

  • drug delivery
  • cell-based platforms
  • ghost erythrocytes
  • stem cells
  • bacterial ghosts
  • extracellular vesicles
  • biomimetic drug delivery systems
  • cell-mimicking particles
  • exosomes

Published Papers (2 papers)

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Research

12 pages, 2007 KiB  
Article
Evaluation of Two Osmosis-Based Methods for the Preparation of Drug Delivery Systems Based on Red Blood Cells
by Carmen Gutierrez-Millan, Celia Barez Diaz, Lydia Alvarez Vizan and Clara I. Colino
Pharmaceutics 2023, 15(9), 2281; https://doi.org/10.3390/pharmaceutics15092281 - 05 Sep 2023
Viewed by 1017
Abstract
Erythrocytes have been thoroughly investigated as drug delivery systems for a wide range of therapeutic molecules and using different kinds of loading methods, outstanding the osmosis-based methods as the most used ones. Most of them involve too much handling of blood components and [...] Read more.
Erythrocytes have been thoroughly investigated as drug delivery systems for a wide range of therapeutic molecules and using different kinds of loading methods, outstanding the osmosis-based methods as the most used ones. Most of them involve too much handling of blood components and the immediate obtention of fresh blood. Based on our group’s considerable experience in dialysis-based carrier erythrocyte preparation, this study details a simple method based on hypotonic dilution and subsequent resealing that has been developed for stavudine using packed erythrocytes from a local blood bank. Properties of the obtained carrier erythrocytes were studied in comparison to those prepared by dialysis. Erythrocytes’ morphology, osmotic fragility, hematological parameters, and in vitro release profiles were evaluated. Loaded erythrocytes obtained with the proposed method did not show impaired properties in comparison with those obtained with our reference method, provided that the buffer composition remained the same. In the present work, we have optimized a simplified method for erythrocytes’ drug loading, which can use blood transfusion products and could be easily automatized and scalable. Full article
(This article belongs to the Special Issue Novel Cell and Bioinspired Drug Delivery Systems)
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12 pages, 2663 KiB  
Article
Blautia coccoides JCM1395T Achieved Intratumoral Growth with Minimal Inflammation: Evidence for Live Bacterial Therapeutic Potential by an Optimized Sample Preparation and Colony PCR Method
by Shoko Nomura, Erike W. Sukowati, Yuko Shigeno, Maiko Takahashi, Akari Kato, Yoshimi Benno, Fumiyoshi Yamashita and Hidefumi Mukai
Pharmaceutics 2023, 15(3), 989; https://doi.org/10.3390/pharmaceutics15030989 - 19 Mar 2023
Cited by 1 | Viewed by 2455
Abstract
We demonstrate that Blautia coccoides JCM1395T has the potential to be used for tumor-targeted live bacterial therapeutics. Prior to studying its in vivo biodistribution, a sample preparation method for reliable quantitative analysis of bacteria in biological tissues was required. Gram-positive bacteria have [...] Read more.
We demonstrate that Blautia coccoides JCM1395T has the potential to be used for tumor-targeted live bacterial therapeutics. Prior to studying its in vivo biodistribution, a sample preparation method for reliable quantitative analysis of bacteria in biological tissues was required. Gram-positive bacteria have a thick outer layer of peptidoglycans, which hindered the extraction of 16S rRNA genes for colony PCR. We developed the following method to solve the issue; the method we developed is as follows. The homogenates of the isolated tissue were seeded on agar medium, and bacteria were isolated as colonies. Each colony was heat-treated, crushed with glass beads, and further treated with restriction enzymes to cleave DNAs for colony PCR. With this method, Blautia coccoides JCM1395T and Bacteroides vulgatus JCM5826T were individually detected from tumors in mice intravenously receiving their mixture. Since this method is very simple and reproducible, and does not involve any genetic modification, it can be applied to exploring a wide range of bacterial species. We especially demonstrate that Blautia coccoides JCM1395T efficiently proliferate in tumors when intravenously injected into tumor-bearing mice. Furthermore, these bacteria showed minimal innate immunological responses, i.e., elevated serum tumor necrosis factor α and interleukin-6, similar to Bifidobacterium sp., which was previously studied as a therapeutic agent with a small immunostimulating effect. Full article
(This article belongs to the Special Issue Novel Cell and Bioinspired Drug Delivery Systems)
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