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Special Issue "Biodegradable Nanomaterials for Targeted Drug Delivery"

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A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 31 August 2023 | Viewed by 4402

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Prof. Dr. Andriy Grafov

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Materials Chemistry Division, Department of Chemistry, University of Helsinki, 00560 Helsinki, Finland
Interests: nanochemistry; ethnomedical pharmaceutically active compounds; drug; nanoformulation

Special Issue Information

Dear Colleagues,

Nanostructures for targeted drug delivery have attracted increasing attention owing to their ability to improve drug efficacy, enhance the bioavailability of active ingredients, control their release, or provide a possibility to target cells. However, nanomedicine is still at an early stage. Different forms of nanostructures have been used for active targeting based on biorecognition by particular cells beyond purely size-dependent biological and chemical interactions. The development of pharmaceutically active compounds (PhACs) modulating immune response is a challenge for modern medicine.

This volume will deal with many technical problems associated with the synthesis and composition of promising PhACs (including ethnomedical ones) and nano-assemblies containing them, molecular modeling of those systems and their interactions, their uptake into the target cell, efficient stimuli- triggered payload release, and their bioavailability, toxicity profiles, and immunomodulatory activity.

Prof. Dr. Andriy Grafov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

nanomedicine
bioavailability
nanoformulation
drug delivery
toxicity
immunomodulation
molecular simulations

Published Papers (5 papers)

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Research

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Open AccessArticle

One Step Purification—Vaccine Delivery System

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Pharmaceutics 2023, 15(5), 1390; https://doi.org/10.3390/pharmaceutics15051390 - 01 May 2023

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Abstract

Glucan particles (GPs) are hollow, porous 3–5 µm microspheres derived from the cell walls of Baker’s yeast (Saccharomyces cerevisiae). Their 1,3-β-glucan outer shell allows for receptor-mediated uptake by macrophages and other phagocytic innate immune cells expressing β-glucan receptors. GPs have been used for the targeted delivery of a wide range of payloads, including vaccines and nanoparticles, encapsulated inside the hollow cavity of GPs. In this paper, we describe the methods to prepare GP-encapsulated nickel nanoparticles (GP-Ni) for the binding of histidine (His)-tagged proteins. His-tagged Cda2 cryptococcal antigens were used as payloads to demonstrate the efficacy of this new GP vaccine encapsulation approach. The GP-Ni-Cda2 vaccine was shown to be comparable to our previous approach utilizing mouse serum albumin (MSA) and yeast RNA trapping of Cda2 in GPs in a mouse infection model. This novel GP-Ni approach allows for the one-step binding of His-tagged vaccine antigens and encapsulation in an effective delivery vehicle to target vaccines to antigen-presenting cells (APCs), antigen discovery, and vaccine development. Full article

(This article belongs to the Special Issue Biodegradable Nanomaterials for Targeted Drug Delivery)

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Open AccessArticle

Recombinant Proteins for Assembling as Nano- and Micro-Scale Materials for Drug Delivery: A Host Comparative Overview

José Luis Corchero

Marianna T. P. Favaro

Merce Márquez-Martínez

Jara Lascorz

Carlos Martínez-Torró

Julieta M. Sánchez

Hèctor López-Laguna

Luís Carlos de Souza Ferreira

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Pharmaceutics 2023, 15(4), 1197; https://doi.org/10.3390/pharmaceutics15041197 - 09 Apr 2023

Viewed by 943

Abstract

By following simple protein engineering steps, recombinant proteins with promising applications in the field of drug delivery can be assembled in the form of functional materials of increasing complexity, either as nanoparticles or nanoparticle-leaking secretory microparticles. Among the suitable strategies for protein assembly, the use of histidine-rich tags in combination with coordinating divalent cations allows the construction of both categories of material out of pure polypeptide samples. Such molecular crosslinking results in chemically homogeneous protein particles with a defined composition, a fact that offers soft regulatory routes towards clinical applications for nanostructured protein-only drugs or for protein-based drug vehicles. Successes in the fabrication and final performance of these materials are expected, irrespective of the protein source. However, this fact has not yet been fully explored and confirmed. By taking the antigenic RBD domain of the SARS-CoV-2 spike glycoprotein as a model building block, we investigated the production of nanoparticles and secretory microparticles out of the versions of recombinant RBD produced by bacteria (Escherichia coli), insect cells (Sf9), and two different mammalian cell lines (namely HEK 293F and Expi293F). Although both functional nanoparticles and secretory microparticles were effectively generated in all cases, the technological and biological idiosyncrasy of each type of cell factory impacted the biophysical properties of the products. Therefore, the selection of a protein biofabrication platform is not irrelevant but instead is a significant factor in the upstream pipeline of protein assembly into supramolecular, complex, and functional materials. Full article

(This article belongs to the Special Issue Biodegradable Nanomaterials for Targeted Drug Delivery)

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Open AccessArticle

Electrospun Nanofibers Loaded with Plantago major L. Extract for Potential Use in Cutaneous Wound Healing

Javier M. Anaya-Mancipe

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Rossana M. S. M. Thiré

Pharmaceutics 2023, 15(4), 1047; https://doi.org/10.3390/pharmaceutics15041047 - 24 Mar 2023

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Abstract

Plantago major L. is a plant available worldwide that has been traditionally used for several medical applications due to its wound healing, anti-inflammatory, and antimicrobial properties. This work aimed to develop and evaluate a nanostructured PCL electrospun dressing with P. major extract encapsulated in nanofibers for applications in wound healing. The extract from leaves was obtained by extraction in a mixture of water:ethanol = 1:1. The freeze-dried extract presented a minimum inhibitory concentration (MIC) for Staphylococcus Aureus susceptible and resistant to methicillin of 5.3 mg/mL, a high antioxidant capacity, but a low content of total flavonoids. Electrospun mats without defects were successfully produced using two P. major extract concentrations based on the MIC value. The extract incorporation in PCL nanofibers was confirmed using FTIR and contact angle measurements. The PCL/P. major extract was evaluated using DSC and TGA demonstrating that the incorporation of the extract decreases the thermal stability of the mats as well as the degree of crystallinity of PCL-based fibers. The P. major extract incorporation on electrospun mats produced a significant swelling degree (more than 400%) and increased the capacity of adsorbing wound exudates and moisture, important characteristics for skin healing. The extract-controlled release evaluated using in vitro study in PBS (pH, 7.4) shows that the P. major extract delivery from the mats occurs in the first 24 h, demonstrating their potential capacity to be used in wound healing. Full article

(This article belongs to the Special Issue Biodegradable Nanomaterials for Targeted Drug Delivery)

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Open AccessArticle

Polylactic Acid/Poly(vinylpyrrolidone) Co-Electrospun Fibrous Membrane as a Tunable Quercetin Delivery Platform for Diabetic Wounds

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Pharmaceutics 2023, 15(3), 805; https://doi.org/10.3390/pharmaceutics15030805 - 01 Mar 2023

Cited by 2 | Viewed by 866

Abstract

Diabetic wound infections (DWI) represent one of the most costly and disruptive complications in diabetic mellitus. The hyperglycemic state induces a persistent inflammation with immunological and biochemical impairments that promotes delayed wound healing processes and wound infection that often results in extended hospitalization and limb amputations. Currently, the available therapeutic options for the management of DWI are excruciating and expensive. Hence, it is essential to develop and improve DWI-specific therapies able to intervene on multiple fronts. Quercetin (QUE) exhibits excellent anti-inflammatory, antioxidant, antimicrobial and wound healing properties, which makes it a promising molecule for the management of diabetic wounds. In the present study, Poly-lactic acid/poly(vinylpyrrolidone) (PP) co-electrospun fibers loaded with QUE were developed. The results demonstrated a bimodal diameter distribution with contact angle starting from 120°/127° and go to 0° in less than 5 s indicating the hydrophilic nature of fabricated samples. The release QUE kinetics, analyzed in simulated wound fluid (SWF), revealed a strong initial burst release, followed by a constant and continuous QUE release. Moreover, QUE-loaded membranes present excellent antibiofilm and anti-inflammatory capacity and significantly reduce the gene expression of M1 markers tumor necrosis factor (TNF)-α, and IL-1β in differentiated macrophages. In conclusion, the results suggested that the prepared mats loaded with QUE could be a hopeful drug-delivery system for the effective treatment of diabetic wound infections. Full article

(This article belongs to the Special Issue Biodegradable Nanomaterials for Targeted Drug Delivery)

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Review

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Open AccessReview

Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration

Marta Bianchini

Silvestro Micera

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Eugenio Redolfi Riva

Pharmaceutics 2023, 15(2), 640; https://doi.org/10.3390/pharmaceutics15020640 - 14 Feb 2023

Viewed by 951

Abstract

When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the nerve regeneration process. However, in the case of consistent peripheral nerve damage, the regeneration capabilities are poor. Hence, a crucial challenge in this field is the development of biodegradable micro- nanostructured polymeric carriers for controlled and sustained release of molecules to enhance nerve regeneration. The aim of these systems is to favor the cellular processes that support nerve regeneration to increase the functional recovery outcome. Drug delivery systems (DDSs) are interesting solutions in the nerve regeneration framework, due to the possibility of specifically targeting the active principle within the site of interest, maximizing its therapeutical efficacy. The scope of this review is to highlight the recent advances regarding the study of biodegradable polymeric DDS for nerve regeneration and to discuss their potential to enhance regenerative performance in those clinical scenarios characterized by severe nerve damage. Full article

(This article belongs to the Special Issue Biodegradable Nanomaterials for Targeted Drug Delivery)

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