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Pharmaceutics
Special Issues
Nanotechnology-Based Drug Delivery Systems, 2nd Edition
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Nanotechnology-Based Drug Delivery Systems, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 6935

Special Issue Editor

Dr. Andrey Kuskov

E-Mail Website
Guest Editor
Department of Technology of Chemical Pharmaceutical and Cosmetic Substances, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia
Interests: nanoparticle preparation; polymers; biomaterials; nanobiotechnology; nanoscience; polymer nanoscience; nanotechnology in drug delivery; polymeric biomaterials; nanoparticles; controlled drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

To date, there has been growing interest in the use of nanotechnologies for the creation and investigation of drug delivery systems (DDSs) in the development of novel forms of efficient pharmaceutical dosages. Such nanosized drug carriers may be used not only to maintain a required blood level of a pharmaceutical agent for an extended period of time for a better drug bioavailability, but also to decrease a drug’s toxicity or provide the dissolubility of poorly soluble active substances for injection-administrated medicines in the form of highly dispersed aqueous systems. Numerous nanoscaled DDSs, such as liposomes, metal nanoparticles, carbon nanoparticles and nanotubes, nanocrystals, polymeric nanospheres, nanocapsules and micelles, dendrimers, ghost bacteria and viruses, and even quantum dots, are being thoroughly investigated for the delivery of various drugs and diagnostic agents, both of a low- and high-molecular-weight origin.

The aim of this Special Issue of the Pharmaceutics journal is to collect research and review papers regarding nanotechnology-based DDS applications in the pharmaceutical field. We welcome articles dealing with all aspects of nanoscaled drug-delivery systems and invite researchers and drug developers to publish their original research or review articles, including expert opinions and perspectives in the area of therapeutics and diagnostics.

Dr. Andrey Kuskov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery system
  • nanoparticle
  • controlled release
  • targeted delivery
  • bioavailability
  • nanotoxicity
  • nanoscale
  • theranostic

Related Special Issue

Published Papers (4 papers)

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Research

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16 pages, 6846 KiB  
Article
Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models
by Anna L. Luss, Dmitry V. Bagrov, Anne V. Yagolovich, Ekaterina V. Kukovyakina, Irina I. Khan, Vadim S. Pokrovsky, Maria V. Shestovskaya, Marine E. Gasparian, Dmitry A. Dolgikh and Andrey N. Kuskov
Pharmaceutics 2024, 16(1), 8; https://doi.org/10.3390/pharmaceutics16010008 - 19 Dec 2023
Viewed by 1440
Abstract
Curcumin attracts huge attention because of its biological properties: it is antiproliferative, antioxidant, anti-inflammatory, immunomodulatory and so on. However, its usage has been limited by poor water solubility and low bioavailability. Herein, to solve these problems, we developed curcumin-loaded nanoparticles based on end-capped [...] Read more.
Curcumin attracts huge attention because of its biological properties: it is antiproliferative, antioxidant, anti-inflammatory, immunomodulatory and so on. However, its usage has been limited by poor water solubility and low bioavailability. Herein, to solve these problems, we developed curcumin-loaded nanoparticles based on end-capped amphiphilic poly(N-vinylpyrrolidone). Nanoparticles were obtained using the solvent evaporation method and were characterized by dynamic and electrophoretic light scattering, transmission electron (TEM) and atomic force (AFM) microscopy. The average particle size was 200 nm, and the ζ-potential was −4 mV. Curcumin-release studies showed that nanoparticles are stable in aqueous solutions. An in vitro release study showed prolonged action in gastric, intestinal and colonic fluids, consistently, and in PBS. In vitro studies on epidermoid carcinoma and human embryonic kidney cells showed that the cells absorbed more curcumin in nanoparticles compared to free curcumin. Nanoparticles are safe for healthy cells and show high cytotoxicity for glioblastoma cells in cytotoxicity studies in vitro. The median lethal dose was determined in an acute toxicity assay on zebrafish and was 23 μM. Overall, the curcumin-loaded nanoparticles seem promising for cancer treatment. Full article
(This article belongs to the Special Issue Nanotechnology-Based Drug Delivery Systems, 2nd Edition)
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21 pages, 9606 KiB  
Article
Enhancing Osteoporosis Treatment through Targeted Nanoparticle Delivery of Risedronate: In Vivo Evaluation and Bioavailability Enhancement
by Zoya Saifi, Sadat Shafi, Tanya Ralli, Shreshta Jain, Divya Vohora, Showkat Rasool Mir, Abdulsalam Alhalmi, Omar M. Noman, Ahmad Alahdab and Saima Amin
Pharmaceutics 2023, 15(9), 2339; https://doi.org/10.3390/pharmaceutics15092339 - 18 Sep 2023
Viewed by 1165
Abstract
Risedronate-loaded mPEG-coated hydroxyapatite, thiolated chitosan-based (coated) and non-coated nanoparticles were tested for their potential effects in the treatment of osteoporosis. The prepared nanoparticles were evaluated for their bone-targeting potential by inducing osteoporosis in female Wistar rats via oral administration of Dexona (dexamethasone sodium [...] Read more.
Risedronate-loaded mPEG-coated hydroxyapatite, thiolated chitosan-based (coated) and non-coated nanoparticles were tested for their potential effects in the treatment of osteoporosis. The prepared nanoparticles were evaluated for their bone-targeting potential by inducing osteoporosis in female Wistar rats via oral administration of Dexona (dexamethasone sodium phosphate). In vivo pharmacokinetic and pharmacodynamic studies were performed on osteoporotic rat models treated with different formulations. The osteoporotic model treated with the prepared nanoparticles indicated a significant effect on bone. The relative bioavailability was enhanced for RIS-HA-TCS-mPEG nanoparticles given orally compared to RIS-HA-TCS, marketed, and API suspension. Biochemical investigations also showed a significant change in biomarker levels, ultimately leading to bone formation/resorption. Micro-CT analysis of bone samples also demonstrated that the RIS-HA-TCS-mPEG-treated group showed the best results compared to other treatment groups. Moreover, the histology of bone treated with RIS-HA-TCS-mPEG showed a marked restoration of the architecture of trabecular bone along with a well-connected bone matrix and narrow inter-trabecular spaces compared to the toxic group. A stability analysis was also carried out according to ICH guidelines (Q1AR2), and it was found that RIS-HA-TCS-mPEG was more stable than RIS-HA-TCS at 25 °C. Thus, the results of present study indicated that mPEG-RIS-HA-TCS has excellent potential for sustained delivery of RIS for the treatment and prevention of osteoporosis, and for minimizing the adverse effects of RIS typically induced via oral administration. Full article
(This article belongs to the Special Issue Nanotechnology-Based Drug Delivery Systems, 2nd Edition)
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14 pages, 4082 KiB  
Article
Colloidal Silver Nanoparticles Obtained via Radiolysis: Synthesis Optimization and Antibacterial Properties
by Mario Menéndez Miranda, Wenbo Liu, Jesus Alfredo Godinez-Leon, Aisara Amanova, Ludivine Houel-Renault, Isabelle Lampre, Hynd Remita and Ruxandra Gref
Pharmaceutics 2023, 15(7), 1787; https://doi.org/10.3390/pharmaceutics15071787 - 21 Jun 2023
Cited by 3 | Viewed by 1386
Abstract
Silver nanoparticles (AgNPs) with broad-spectrum antimicrobial properties are gaining increasing interest in fighting multidrug-resistant bacteria. Herein, we describe the synthesis of AgNPs, stabilized by polyvinyl alcohol (PVA), with high purity and homogeneous sizes, using radiolysis. Solvated electrons and reducing radicals are induced from [...] Read more.
Silver nanoparticles (AgNPs) with broad-spectrum antimicrobial properties are gaining increasing interest in fighting multidrug-resistant bacteria. Herein, we describe the synthesis of AgNPs, stabilized by polyvinyl alcohol (PVA), with high purity and homogeneous sizes, using radiolysis. Solvated electrons and reducing radicals are induced from solvent radiolysis and no other chemical reducing agents are needed to reduce the metal ions. Another advantage of this method is that it leads to sterile colloidal suspensions, which can be directly used for medical applications. We systematically investigated the effect of the silver salt precursor on the optical properties, particle size, and morphology of the resulting colloidal AgNPs. With Ag2SO4 precursor, the AgNPs displayed a narrow size distribution (20 ± 2 nm). In contrast, AgNO3 and AgClO4 precursors lead to inhomogeneous AgNPs of various shapes. Moreover, the optimized AgNPs synthesized from Ag2SO4 were stable upon storage in water and phosphate-buffered saline (PBS) and were very effective in inhibiting the growth of Staphylococcus aureus (S. aureus) at a concentration of 0.6 μg·mL−1 while completely eradicating it at a concentration of 5.6 μg·mL−1. When compared with other AgNPs prepared by other strategies, the remarkable bactericidal ability against S. aureus of the AgNPs produced here opens up new perspectives for further applications in medicine, cosmetics, the food industry, or in elaborating antibacterial surfaces and other devices. Full article
(This article belongs to the Special Issue Nanotechnology-Based Drug Delivery Systems, 2nd Edition)
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Review

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18 pages, 1207 KiB  
Review
Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity
by Maria V. Shestovskaya, Anna L. Luss, Olga A. Bezborodova, Valentin V. Makarov and Anton A. Keskinov
Pharmaceutics 2023, 15(10), 2406; https://doi.org/10.3390/pharmaceutics15102406 - 30 Sep 2023
Cited by 3 | Viewed by 2445
Abstract
The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads to an increase in the potency of radiation therapy and allows for decreasing radiation dose and the concomitant side effects. Radiosensitization by metal oxide nanoparticles is [...] Read more.
The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads to an increase in the potency of radiation therapy and allows for decreasing radiation dose and the concomitant side effects. Radiosensitization by metal oxide nanoparticles is widely discussed, but the range of mechanisms studied is not sufficiently codified and often does not reflect the ability of nanocarriers to have a specific impact on cells. This review is focused on the magnetic iron oxide nanoparticles while they occupied a special niche among the prospective radiosensitizers due to unique physicochemical characteristics and reactivity. We collected data about the possible molecular mechanisms underlying the radiosensitizing effects of iron oxide nanoparticles (IONPs) and the main approaches to increase their therapeutic efficacy by variable modifications. Full article
(This article belongs to the Special Issue Nanotechnology-Based Drug Delivery Systems, 2nd Edition)
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