Biomedical Applications and Biosafety Assessment of Biologically Fabricated Nanomaterials

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2509

Special Issue Editors

Marine College, Shandong University, Weihai 264209, China
Interests: nanobiotechnology; nanomedicine; nanobiomaterials; biopolymers; polymeric biomaterials; bionano composites; polymeric nanocomposites; nano drug delivery; marine polymers; microbial biofilm control; food packaging
Special Issues, Collections and Topics in MDPI journals
Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPIbpC), Partner Laboratory of the Max Planck Institute for Biophysical Chemistry (MPIbpC, MPG), CONICET Rosario, Maipú 1065, Rosario S2000, Argentina
Interests: nanobiomaterials; drug delivery; biomaterials; biopolymers; nanoparticles (lipid, metallic, polymeric); biocatalysis; enzyme immobilization
Special Issues, Collections and Topics in MDPI journals
Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires 1113, Argentina
Interests: biomaterials; nanomaterials; nanocomposites; wound healing; bionanotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The general word "nanobiotechnology," which describes the connection between nanotechnology and biology, is now receiving significant attention as a cutting-edge field of study. It is extensively used to produce very small materials that are helpful in a variety of disciplines, including biology, material science, and especially energy science. Nanobiotechnology is regarded as an advanced subject in the field of technology. Applications of nanobiotechnology have progressed in numerous fields over the past few decades. Every element of contemporary living now benefits from the use of nanoparticles (NP) and nanocomposites, including healthcare, food packing, food preservation, and other sectors. Industries have been forced to produce metal and metal oxide nanoparticles on a large scale in order to satisfy market demand and supply, but with such pervasive use in commerce, safety concerns have also been raised about the toxicity of these nanomaterials. Metal and metal oxides are produced and used extensively, which leads to their gradual build up and concern over their harm to both human health and the environment (plants and animals). Researchers have evaluated the biosafety evaluation or toxicity of metal and metal oxides using various in vitro and in vivo models, including cell lines, plants, mice, and zebrafish, to resolve this issue.

This Special Issue research topic intends to collect recent advances that focus on the synthesis, physicochemical characterization, functionalization, and biomedical applications and biosafety assessments of novel biofabricated various nanomaterials. We invite authors to submit manuscripts for publication in this Special Issue. We welcome research papers focused on emerging bionanomaterials, and their potential applications in the biomedical field, i.e., nano chemotherapy, nanoantibiotics, nano drug delivery, nanophototherapy, in vitro and in vivo studies and nanoecotoxicology. Original research articles, reviews, but not limited to, the following keywords can be included:

  • Bionanomaterials;
  • Nanocomposites and nanoparticles;
  • Anticancer;
  • Antibiofilm;
  • Wound healing;
  • Microbial synthesis;
  • Green synthesis (plants and gums);
  • Biosynthesis (animal-based or protein);
  • In vivo toxicity analysis (rats, mice and rabbits);
  • In vitro studies;
  • Ecotoxicity analysis (zebra fish, Artemia, Daphnia, phytotoxicity and C.elegans);
  • Biological activities (antimicrobial, antioxidant, antidiabetic, etc.).

Dr. Vijayakumar Sekar
Prof. Dr. Guillermo R. Castro
Dr. Martin Federico Desimone
Guest Editors

Manuscript Submission Information

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Published Papers (1 paper)

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Review

48 pages, 6275 KiB  
Review
Updates on Biogenic Metallic and Metal Oxide Nanoparticles: Therapy, Drug Delivery and Cytotoxicity
by Maria P. Nikolova, Payal B. Joshi and Murthy S. Chavali
Pharmaceutics 2023, 15(6), 1650; https://doi.org/10.3390/pharmaceutics15061650 - 03 Jun 2023
Cited by 7 | Viewed by 2113
Abstract
The ambition to combat the issues affecting the environment and human health triggers the development of biosynthesis that incorporates the production of natural compounds by living organisms via eco-friendly nano assembly. Biosynthesized nanoparticles (NPs) have various pharmaceutical applications, such as tumoricidal, anti-inflammatory, antimicrobials, [...] Read more.
The ambition to combat the issues affecting the environment and human health triggers the development of biosynthesis that incorporates the production of natural compounds by living organisms via eco-friendly nano assembly. Biosynthesized nanoparticles (NPs) have various pharmaceutical applications, such as tumoricidal, anti-inflammatory, antimicrobials, antiviral, etc. When combined, bio-nanotechnology and drug delivery give rise to the development of various pharmaceutics with site-specific biomedical applications. In this review, we have attempted to summarize in brief the types of renewable biological systems used for the biosynthesis of metallic and metal oxide NPs and the vital contribution of biogenic NPs as pharmaceutics and drug carriers simultaneously. The biosystem used for nano assembly further affects the morphology, size, shape, and structure of the produced nanomaterial. The toxicity of the biogenic NPs, because of their pharmacokinetic behavior in vitro and in vivo, is also discussed, together with some recent achievements towards enhanced biocompatibility, bioavailability, and reduced side effects. Because of the large biodiversity, the potential biomedical application of metal NPs produced via natural extracts in biogenic nanomedicine is yet to be explored. Full article
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