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Pharmaceutics
Special Issues
Novel Vaginal Drug Delivery Systems
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Novel Vaginal Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (25 September 2022) | Viewed by 5774

Special Issue Editors

Dr. José das Neves

E-Mail Website
Guest Editor
i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal
Interests: HIV/AIDS; nanomedicine; microbicides; vaginal drug delivery; women’s health
Special Issues, Collections and Topics in MDPI journals
Dr. Fernando Notario-Pérez

E-Mail Website
Guest Editor
Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
Interests: film technology; HIV/ADS prevention; mucoadhesion; topical pre-exposure prophylaxis; vaginal drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The intravaginal administration of drugs constitutes a longstanding and valuable practice in the promotion of women’s health. Major advances have been achieved in the field over the last two decades, largely propelled by the development of vaginal microbicides for preventing sexual HIV transmission. The ongoing regulatory approval of the dapivirine ring in various countries is just one good example of the accomplishments made in this area. Other clinical applications have also benefited from such developments (e.g., the treatment of sexually transmitted infections, contraception, pregnancy support, etc.) and their clinical translation is already in progress. Proper design and testing of drug delivery systems and dosage forms play a key role in the success of products intended for vaginal use, but, despite all the excitement in the field, substantial work and innovative solutions are still needed. As guest editors, we would like to encourage colleagues to submit their research work in the format of full papers or communications, as well as pertinent reviews, in all subjects pertaining to the development and characterization of drug delivery systems intended for human or veterinary vaginal use, and with application in diagnostics, imaging, therapy, prophylaxis or regenerative medicine.

Dr. José das Neves
Dr. Fernando Notario-Pérez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cervical cancer
  • contraception
  • drug delivery systems
  • drug products
  • labor inducement
  • microbicides
  • microcarriers
  • mucoadhesion
  • mucosal drug delivery
  • multipurpose prevention technologies (MPTs)
  • nanocarriers
  • nanomedicine
  • pregnancy support
  • sexually transmitted infections
  • spermicides
  • vaginal absorption
  • vaginal drug delivery
  • vaginal films
  • vaginal foams
  • vaginal gels
  • vaginal irritation
  • vaginal microbiota
  • vaginal models
  • vaginal mucosa
  • vaginal permeability
  • vaginal physiology
  • vaginal rings
  • vaginal sponges
  • vaginal suppositories
  • vulvovaginal candidiasis

Published Papers (2 papers)

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Research

15 pages, 2632 KiB  
Article
Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginalTM Tissue Model
by May Wenche Jøraholmen, Pauliina Damdimopoulou, Ganesh Acharya and Nataša Škalko-Basnet
Pharmaceutics 2022, 14(6), 1295; https://doi.org/10.3390/pharmaceutics14061295 - 17 Jun 2022
Cited by 3 | Viewed by 2228
Abstract
The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with [...] Read more.
The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydrogel as secondary vehicle. Although considered non-toxic and safe on their own, the compatibility of the final formulation must be evaluated for its biocompatibility and non-irritancy to the vaginal mucosa. As a preclinical safety assessment, the impact of RES formulation on the tissue viability, the effect on barrier function and cell monolayer integrity, and cytotoxicity were evaluated using the cell-based vaginal tissue model, the EpiVaginal™ tissue. RES liposomes-in-hydrogel formulations neither affected the mitochondrial activity, nor the integrity of the cell monolayer in RES concentration up to 60 µg/mL. Moreover, the barrier function was maintained to a greater extent by RES in formulation, emphasizing the benefits of the delivery system. Additionally, none of the tested formulations expressed an increase in lactate dehydrogenase activity compared to the non-treated tissues. The evaluation of the RES delivery system suggests that it is non-irritant and biocompatible with vaginal tissue in vitro in the RES concentrations considered as therapeutic. Full article
(This article belongs to the Special Issue Novel Vaginal Drug Delivery Systems)
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17 pages, 2422 KiB  
Article
Development of a Novel Vaginal Drug Delivery System to Control Time of Farrowing and Allow Supervision of Piglet Delivery
by Sophia A. Ward, Roy N. Kirkwood, Kate J. Plush, Sadikalmahdi Abdella, Yunmei Song and Sanjay Garg
Pharmaceutics 2022, 14(2), 340; https://doi.org/10.3390/pharmaceutics14020340 - 31 Jan 2022
Cited by 3 | Viewed by 2646
Abstract
The swine industry has evolved significantly in the recent decades, but this has come at considerable expense to piglet survival. Breeding sows for greater prolificacy has been accompanied by a greater proportion of piglets being born underweight, of lower vigor, and higher susceptibility [...] Read more.
The swine industry has evolved significantly in the recent decades, but this has come at considerable expense to piglet survival. Breeding sows for greater prolificacy has been accompanied by a greater proportion of piglets being born underweight, of lower vigor, and higher susceptibility to early mortality. Inducing sows to farrow during working hours has the potential to increase piglet survivability, but non-therapeutic injectable products are often discouraged on farms. We aimed to design and develop a novel vaginal drug delivery system (NVDDS) that could reliably trigger luteolysis and induce parturition. To achieve this, two vaginal tablets containing the luteolytic agent cloprostenol were formulated to be inserted together: one would release constituents immediately on insertion (immediate release; IR) and the other would release cloprostenol in a controlled manner (controlled release; CR). The two formulations (IR and CR) were evaluated for drug release, swelling and bio-adhesion in conditions simulating the sow vaginal environment. The IR tablet released the drug completely for 5 min whereas the CR tablet took 5 h to release 50% of the drug. Furthermore, the release kinetics were evaluated by fitting the dissolution profiles into different mathematical models. Both IR and CR tablets were best fitted by the Makoid–Banakar model which assumes release by summation of different mechanisms. The performance of the optimized formulations was studied in vivo with 161 Large White x Landrace sows of varying parity (0–5). The sows were assigned to five groups. Group 1 (SI) received a single vulval injection of cloprostenol at 0700 h (n = 32), group 2 (SDI) received the same dose split in two parts, at 0700h and 1300h (n = 33). Group 3 (IRT) animals were administered an IR tablet at 0700h (n = 32), while group 4 (IRCRT) received both IR and CR tablets at 0700 h (n = 33). Group 5 was untreated and served as a control (n = 32). The interval to farrowing was longer (p < 0.001) for controls than for treated sows, but there were no differences among cloprostenol treatments for timing of farrowing. The finding confirms the efficacy of the NVDDS for induction of farrowing in sows. Full article
(This article belongs to the Special Issue Novel Vaginal Drug Delivery Systems)
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