Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Advances in Solid Lipid Micro- and Nanoparticle Technology, 2nd Edition
share announcement

Advances in Solid Lipid Micro- and Nanoparticle Technology, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1356

Special Issue Editors

Dr. Stefano Giovagnoli

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy
Interests: controlled release; solid state properties; organic and inorganic nano- microparticles; inhaled dry powders; drug physical modification; cell microencapsulation and engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Paolo Blasi

E-Mail Website
Guest Editor
Department of Pharmacy and Biotechnology, University of Bologna, 40127 Bologna, Italy
Interests: drug delivery; pharmaceutical nanotechnology; nanomedicine; pulmonary drug delivery; cell encapsulation; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Aurélie Schoubben

E-Mail Website
Guest Editor
Department of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy
Interests: controlled release; inhaled dry powders; drug physical modification; micro- and nanoparticles; drug targeting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Undoubtedly, solid lipid micro- and nanoparticles show high potential in a number of different therapeutic areas. The massive use of lipid nanoparticles in COVID-19 mRNA vaccines has shed new light on these carriers due to the proven safety and the availability of large-scale manufacturing, ranking solid lipid particles among the most attractive technologies. Unfortunately, the intrinsic solid-state properties of lipids are detrimental to particle storage stability and sometimes restrict their market appeal. Therefore, in spite of the recorded progress, solid lipid particle technology is still striving to overcome unmet development issues.

This Special Issue aims to include the most recent research efforts addressing lipid particle technology challenges. Special attention will be dedicated to manufacturing and novel cutting-edge technologies that may help prevent the well-known issues of lipid materials and could foster the industrial development of these versatile delivery systems. 

Detailed topics are: advanced manufacturing techniques; new solid lipid particle engineering approaches to enhance stability and delivery performances; new approaches in the use of solid lipid particles for targeted or local drug delivery; and technologies addressing the delivery of large biomacromolecules, such as peptide, proteins, DNA, siRNA and mRNA.

Dr. Stefano Giovagnoli
Dr. Paolo Blasi
Dr. Aurélie Schoubben
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • solid lipid nanoparticles
  • solid lipid microparticles
  • manufacturing methods
  • targeted delivery
  • local delivery
  • small interfering RNA, siRNA
  • messenger RNA, mRNA
  • proteins and peptides
  • solid-state properties
  • stability

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 3755 KiB  
Article
Lipid Nanoparticles Loading Steroidal Alkaloids of Tomatoes Affect Neuroblastoma Cell Viability in an In Vitro Model
by Debora Santonocito, Agatina Campisi, Rosalia Pellitteri, Giovanni Sposito, Manuela Giovanna Basilicata, Giovanna Aquino, Giacomo Pepe, Maria Grazia Sarpietro, Maria Gaetana Giovanna Pittalà, Aurelie Schoubben, Rosario Pignatello and Carmelo Puglia
Pharmaceutics 2023, 15(11), 2573; https://doi.org/10.3390/pharmaceutics15112573 - 02 Nov 2023
Cited by 2 | Viewed by 1091
Abstract
Tomato by-products represent a good source of phytochemical compounds with health properties, such as the steroidal glycoalkaloid α-tomatine (α-TM) and its aglycone tomatidine (TD). Both molecules have numerous beneficial properties, such as potential anticancer activity. Unfortunately, their therapeutic application is limited due to [...] Read more.
Tomato by-products represent a good source of phytochemical compounds with health properties, such as the steroidal glycoalkaloid α-tomatine (α-TM) and its aglycone tomatidine (TD). Both molecules have numerous beneficial properties, such as potential anticancer activity. Unfortunately, their therapeutic application is limited due to stability and bioavailability issues. Therefore, a valid strategy seems to be their encapsulation into Solid Lipid Nanoparticles (SLN). The nanoformulations containing α-TM (α-TM-SLN) and TD (TD-SLN) were prepared by solvent-diffusion technique and subsequently characterized in terms of technological parameters (particle size, polydispersity index, zeta potential, microscopy, and calorimetric studies). To assess the effect of α-TM and TD on the percentage of cellular viability in Olfactory Ensheathing Cells (OECs), a peculiar glial cell type of the olfactory system used as normal cells, and in SH-SY5Y, a neuroblastoma cancer cell line, an MTT test was performed. In addition, the effects of empty, α-TM-SLN, and TD-SLN were tested. Our results show that the treatment of OECs with blank-SLN, free α-TM (0.25 µg/mL), and TD (0.50 µg/mL) did not induce any significant change in the percentage of cell viability when compared with the control. In contrast, in SH-SY5Y-treated cells, a significant decrease in the percentage of cell viability when compared with the control was found. In particular, the effect appeared more evident when SH-SY5Y cells were exposed to α-TM-SLN and TD-SLN. No significant effect in blank-SLN-treated SH-SY5T cells was observed. Therefore, SLN is a promising approach for the delivery of α-TM and TD. Full article
(This article belongs to the Special Issue Advances in Solid Lipid Micro- and Nanoparticle Technology, 2nd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop