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Pharmaceutics
Special Issues
The Role of Free Radicals and Antioxidants in Drug Activation...
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The Role of Free Radicals and Antioxidants in Drug Activation and Effectiveness in Different Biological Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 1533

Special Issue Editors

Dr. Antonio Vassallo

E-Mail Website
Guest Editor
Department of Science, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, Italy
Interests: drug delivery systems; cosmetic products; cosmetic formulations; nanomaterials and nanotechnologies; natural products; herbal medicine; antioxidant and radical scavenging; analytical chemistry; chromatography-mass spectrometry; bioactive compounds and natural extracts
Dr. Ioannis Tsamesidis

E-Mail Website
Guest Editor
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
Interests: oxidative stress; Plasmodium falciparum; artemisinin; red blood cells; thalassemia; nanoparticles; ROS; antioxidants; hemoglobinopathies; antimalarials
Special Issues, Collections and Topics in MDPI journals
Dr. Antonella Pantaleo

E-Mail Website
Guest Editor
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
Interests: oxidative stress biology; hemoglobinopathies; hereditary hemolytic diseases; malaria and drugs; nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Oxidative stress is the result of a disequilibrium in oxidants/antioxidants which results from the continuous increase in the production of reactive oxygen species (ROS) under stress conditions (inflammation, etc.). Remarkable interest has arisen in the idea that oxidative stress and specific free radicals are able to control drug activation and, in some cases, their effectiveness too. The aim of this Special Issue is to gather the latest studies which explore oxidative stress biomarkers (ROS, RNS, free radicals, antioxidants) in cell interactions (human/animal cells, bacteria, parasites) with potential compounds (drugs/edible oils) alone or encapsulated in nanomaterials (nanodrugs) for different biological applications.

Dr. Antonio Vassallo
Dr. Ioannis Tsamesidis
Dr. Antonella Pantaleo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reactive oxygen species
  • free radicals (superoxide and hydroxyl radicals)
  • antioxidants
  • nanomaterials (micro-nano particles)
  • drug activation
  • drug delivery
  • in vitro and in vivo studies
  • polymer and lipid systems
  • edible oils

Published Papers (1 paper)

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Research

20 pages, 2550 KiB  
Article
Study of Biological Behavior and Antimicrobial Properties of Cerium Oxide Nanoparticles
by Iason Chatzimentor, Ioannis Tsamesidis, Maria-Eleni Ioannou, Georgia K. Pouroutzidou, Anastasia Beketova, Veronica Giourieva, Rigini Papi and Eleana Kontonasaki
Pharmaceutics 2023, 15(10), 2509; https://doi.org/10.3390/pharmaceutics15102509 - 23 Oct 2023
Cited by 3 | Viewed by 1212
Abstract
(1) Background: An element that has gained much attention in industrial and biomedical fields is Cerium (Ce). CeO2 nanoparticles have been proven to be promising regarding their different biomedical applications for the control of infection and inflammation. The aim of the present [...] Read more.
(1) Background: An element that has gained much attention in industrial and biomedical fields is Cerium (Ce). CeO2 nanoparticles have been proven to be promising regarding their different biomedical applications for the control of infection and inflammation. The aim of the present study was to investigate the biological properties and antimicrobial behavior of cerium oxide (CeO2) nanoparticles (NPs). (2) Methods: The investigation of the NPs’ biocompatibility with human periodontal ligament cells (hPDLCs) was evaluated via the MTT assay. Measurement of alkaline phosphatase (ALP) levels and alizarine red staining (ARS) were used as markers in the investigation of CeO2 NPs’ capacity to induce the osteogenic differentiation of hPDLCs. Induced inflammatory stress conditions were applied to hPDLCs with H2O2 to estimate the influence of CeO2 NPs on the viability of cells under these conditions, as well as to reveal any ROS scavenging properties. Total antioxidant capacity (TAC) of cell lysates with NPs was also investigated. Finally, the macro broth dilution method was the method of choice for checking the antibacterial capacity of CeO2 against the anaerobic pathogens Porphyromonas gingivalis and Prevotella intermedia. (3) Results: Cell viability assay indicated that hPDLCs increase their proliferation rate in a time-dependent manner in the presence of CeO2 NPs. ALP and ARS measurements showed that CeO2 NPs can promote the osteogenic differentiation of hPDLCs. In addition, the MTT assay and ROS determination demonstrated some interesting results concerning the viability of cells under oxidative stress conditions and, respectively, the capability of NPs to decrease free radical levels over the course of time. Antimicrobial toxicity was observed mainly against P. gingivalis. (4) Conclusions: CeO2 NPs could provide an excellent choice for use in clinical practices as they could prohibit bacterial proliferation and control inflammatory conditions. Full article
(This article belongs to the Special Issue The Role of Free Radicals and Antioxidants in Drug Activation and Effectiveness in Different Biological Systems)
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