Special Issue "Advances in Drug Targeting for Central Nervous System Disease"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 30 June 2023 | Viewed by 1804

Special Issue Editors

Dipartimento di Farmacia, Università degli Studi “G. D'Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy
Interests: Alzheimer's disease; Parkinson's disease; antimicrobials; synthesis of peptides
Special Issues, Collections and Topics in MDPI journals
Department of Pharmacology and Toxicology, Medical University of Lodz, 7/9 Zeligowskiego, 90-752 Lodz, Poland
Interests: endoplasmic reticulum stress; inflammation; NSAIDs; antidepressants; antioxidants; pharmacology
Department of Pharmacology and Toxicology, Medical University of Lodz, 7/9 Zeligowskiego, 90-752 Lodz, Poland
Interests: neuroprotection; neurotoxicology; nanoparticles; nanomedicine; drug development; cell signaling

Special Issue Information

Dear Colleagues,

Central nervous system (CNS) diseases such as psychiatric and neurological are a major challenge for medicine and public health worldwide. Currently available drugs offer temporary relief from the symptoms of the neurodegenerative disorder, but they do not arrest or reverse the disease. Adverse effects and resistance to traditional therapies require looking for new options. CNS diseases are multifaceted disorders with diverse and not fully understood pathophysiological mechanisms, e.g., the development of inflammatory processes, oxidative and endoplasmic reticulum stress, disturbance of neuronal-glial communication. The pathological processes are associated with specific signaling pathways, and their elements can become strategic points for development of new drugs and for new applications of already approved.

This Special Issue of Pharmaceutics titled “Advances in Drug Targeting for Central Nervous System Diseases”, will gather discoveries of new drug targets, drug formation and targeted delivery with emphasis on strategies that may alter signaling pathways involved in pathological processes of CNS diseases to stop their progress or even prevent them. Research papers and Reviews on drugs already approved and new molecules are welcome.

We are looking forward for your contribution.

Dr. Ivana Cacciatore
Dr. Anna Wiktorowska-Owczarek
Dr. Sokołowska Paulina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • CNS diseases
  • disturbance of neuronal-glial communication
  • drug targeting
  • drug formation
  • targeted drug delivery
  • endoplasmic reticulum stress
  • neurodegeneration
  • neuroinflammation
  • neuroplasticity
  • neuroprotection
  • neurotransmitters
  • neurotrophins
  • oxidative stress
  • signaling pathways

Published Papers (1 paper)

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Review

Review
Current Treatments and New, Tentative Therapies for Parkinson’s Disease
Pharmaceutics 2023, 15(3), 770; https://doi.org/10.3390/pharmaceutics15030770 - 25 Feb 2023
Viewed by 1446
Abstract
Parkinson’s disease (PD) is a neurodegenerative pathology, the origin of which is associated with the death of neuronal cells involved in the production of dopamine. The prevalence of PD has increased exponentially. The aim of this review was to describe the novel treatments [...] Read more.
Parkinson’s disease (PD) is a neurodegenerative pathology, the origin of which is associated with the death of neuronal cells involved in the production of dopamine. The prevalence of PD has increased exponentially. The aim of this review was to describe the novel treatments for PD that are currently under investigation and study and the possible therapeutic targets. The pathophysiology of this disease is based on the formation of alpha-synuclein folds that generate Lewy bodies, which are cytotoxic and reduce dopamine levels. Most pharmacological treatments for PD target alpha-synuclein to reduce the symptoms. These include treatments aimed at reducing the accumulation of alpha-synuclein (epigallocatechin), reducing its clearance via immunotherapy, inhibiting LRRK2, and upregulating cerebrosidase (ambroxol). Parkinson’s disease continues to be a pathology of unknown origin that generates a significant social cost for the patients who suffer from it. Although there is still no definitive cure for this disease at present, there are numerous treatments available aimed at reducing the symptomatology of PD in addition to other therapeutic alternatives that are still under investigation. However, the therapeutic approach to this pathology should include a combination of pharmacological and non-pharmacological strategies to maximise outcomes and improve symptomatological control in these patients. It is therefore necessary to delve deeper into the pathophysiology of the disease in order to improve these treatments and therefore the quality of life of the patients. Full article
(This article belongs to the Special Issue Advances in Drug Targeting for Central Nervous System Disease)
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