Special Issue "Transporter-Mediated Drug Interactions"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (31 May 2011) | Viewed by 6774
Advances in the field of in-vitro tools to accurately describe NME’s interactions with enzymes and transport proteins have led to an improved qualitative understanding of putative interaction points and elimination pathways of the NME. Additionally, more sophisticated in vivo methods (KO or humanized animals) are explored and an increasing number of clinical examples of transporter and transporter/enzyme mediated interactions are reported. Scientific and technological development impacts furthermore on the regulatory views on drug interactions. This special issue highlights advances in in vitro and in vivo studies to mechanistically describe drug-transporter interactions and the complementary modeling approaches to quantitatively predict clinical consequences of such interactions. We invite articles covering all aspects from in-vitro work to modeling and clinical interaction studies.
Dr. Constanze Hilgendorf
- vectorial transport
- enzyme-transporter interplay