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Pharmaceutics
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Carbon-Based Nanomaterials as Multifunctional Nanoplatforms for Cancer Diagnosis and Treatment
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Carbon-Based Nanomaterials as Multifunctional Nanoplatforms for Cancer Diagnosis and Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 4421

Special Issue Editors

Dr. Consuelo Celesti

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Guest Editor
Department of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, Italy
Interests: organic Synthesis; nanomedicine; drug delivery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Daniela Iannazzo

E-Mail Website
Guest Editor
Department of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, Italy
Interests: organic chemistry; nanomaterials functionalization; biomaterials for tissue engineering; biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite the outstanding advances in cancer diagnosis and therapy, it still remains a leading cause of death worldwide. The use of conventional chemotherapy is often limited by the systemic toxicity of anticancer drugs and their hydrophobic nature. In this context, carbon-based nanomaterials, including carbon nanotubes, fullerenes, graphene oxide, and graphene quantum dots, have shown unprecedented opportunities in cancer therapy. Their outstanding size-dependent physical, chemical, electrical, and optical properties, their large surface area, and the presence of more reactive groups on the graphene surface allow the multimodal conjugation of these nanomaterials with different functional groups and biologically active molecules, making them ideal nanoplatforms for cancer diagnosis and treatment. Current research in nano-oncology is focused on developing cancer-targeted nanoparticles with the ability to overcome drug resistance mechanisms and achieve a more efficient cancer drug delivery with minimal damage to healthy tissues. The optical properties of engineered small graphene fragments have also shown the potential to revolutionize cancer therapy by developing new theranostic nanoparticles for simultaneous imaging and therapy, thus translating the nanoscale science to benefit patients.

The Special Issue “Carbon-based nanomaterials as Multifunctional Nanoplatforms for Cancer Treatment” aims at collecting full papers, communications, and reviews that clearly demonstrate the ongoing efforts in developing carbon-based materials as nanoplatforms for cancer diagnosis and treatment. This Special Issue aims to cover a broad range of topics, from carbon nanomaterials synthesis to the design and development of nanopharmaceutics to be used as drug delivery systems, imaging agents, and nanotheranostic tools for cancer therapy.

Dr. Consuelo Celesti
Prof. Dr. Daniela Iannazzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon-based nanomaterials
  • drug delivery
  • cancer targeted therapy
  • carbon nanotubes
  • graphene oxide
  • graphene quantum dots
  • carbon nanomaterials functionalization
  • theranostic tools
  • cancer diagnosis
  • bio-imaging

Published Papers (2 papers)

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Research

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18 pages, 4615 KiB  
Article
Orange-Peel-Derived Nanobiochar for Targeted Cancer Therapy
by Daniela Iannazzo, Consuelo Celesti, Claudia Espro, Angelo Ferlazzo, Salvatore V. Giofrè, Mario Scuderi, Silvia Scalese, Bartolo Gabriele, Raffaella Mancuso, Ida Ziccarelli, Giuseppa Visalli and Angela Di Pietro
Pharmaceutics 2022, 14(10), 2249; https://doi.org/10.3390/pharmaceutics14102249 - 21 Oct 2022
Cited by 12 | Viewed by 1944
Abstract
Cancer-targeted drug delivery systems (DDS) based on carbon nanostructures have shown great promise in cancer therapy due to their ability to selectively recognize specific receptors overexpressed in cancer cells. In this paper, we have explored a green route to synthesize nanobiochar (NBC) endowed [...] Read more.
Cancer-targeted drug delivery systems (DDS) based on carbon nanostructures have shown great promise in cancer therapy due to their ability to selectively recognize specific receptors overexpressed in cancer cells. In this paper, we have explored a green route to synthesize nanobiochar (NBC) endowed with graphene structure from the hydrothermal carbonization (HTC) of orange peels and evaluated the suitability of this nanomaterial as a nanoplatform for cancer therapy. In order to compare the cancer-targeting ability of different widely used targeting ligands (TL), we have conjugated NBC with biotin, riboflavin, folic acid and hyaluronic acid and have tested, in vitro, their biocompatibility and uptake ability towards a human alveolar cancer cell line (A549 cells). The nanosystems which showed the best biological performances—namely, the biotin- and riboflavin- conjugated systems—have been loaded with the poorly water-soluble drug DHF (5,5-dimethyl-6a-phenyl-3-(trimethylsilyl)-6,6a-dihydrofuro[3,2-b]furan-2(5H)-one) and tested for their anticancer activity. The in vitro biological tests demonstrated the ability of both systems to internalize the drug in A549 cells. In particular, the biotin-functionalized NBC caused cell death percentages to more than double with respect to the drug alone. The reported results also highlight the positive effect of the presence of oxygen-containing functional groups, present on the NBC surface, to improve the water dispersion stability of the DDS and thus make the approach of using this nanomaterial as nanocarrier for poorly water-soluble drugs effective. Full article
(This article belongs to the Special Issue Carbon-Based Nanomaterials as Multifunctional Nanoplatforms for Cancer Diagnosis and Treatment)
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Review

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49 pages, 8253 KiB  
Review
Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems
by Hugh Mohan, Andrew Fagan and Silvia Giordani
Pharmaceutics 2023, 15(5), 1545; https://doi.org/10.3390/pharmaceutics15051545 - 19 May 2023
Cited by 2 | Viewed by 1873
Abstract
Carbon nanomaterials (CNMs) are an incredibly versatile class of materials that can be used as scaffolds to construct anticancer nanocarrier systems. The ease of chemical functionalisation, biocompatibility, and intrinsic therapeutic capabilities of many of these nanoparticles can be leveraged to design effective anticancer [...] Read more.
Carbon nanomaterials (CNMs) are an incredibly versatile class of materials that can be used as scaffolds to construct anticancer nanocarrier systems. The ease of chemical functionalisation, biocompatibility, and intrinsic therapeutic capabilities of many of these nanoparticles can be leveraged to design effective anticancer systems. This article is the first comprehensive review of CNM-based nanocarrier systems that incorporate approved chemotherapy drugs, and many different types of CNMs and chemotherapy agents are discussed. Almost 200 examples of these nanocarrier systems have been analysed and compiled into a database. The entries are organised by anticancer drug type, and the composition, drug loading/release metrics, and experimental results from these systems have been compiled. Our analysis reveals graphene, and particularly graphene oxide (GO), as the most frequently employed CNM, with carbon nanotubes and carbon dots following in popularity. Moreover, the database encompasses various chemotherapeutic agents, with antimicrotubule agents being the most common payload due to their compatibility with CNM surfaces. The benefits of the identified systems are discussed, and the factors affecting their efficacy are detailed. Full article
(This article belongs to the Special Issue Carbon-Based Nanomaterials as Multifunctional Nanoplatforms for Cancer Diagnosis and Treatment)
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