Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Non-Ionic Surfactant Vesicles for Drug Delivery
share announcement

Non-Ionic Surfactant Vesicles for Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (20 December 2018) | Viewed by 46110

Special Issue Editor

Prof. Dr. Rita Muzzalupo

E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Interests: colloid systems; multifunctional nanoparticles; transdermal and topical delivery; polymeric nanoparticles; controlled release
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The self-assembly of non-ionic surfactants in vesicular structures is an object of research in pharmaceutical technology. In particular, these formulations have been developed for the many advantages offered by these systems, for example, the ability to increase the capacity of delivery vehicles as drug release control, to reduce drug side effects, to increase drug solubilization, to reduce drug degradation, and also to control drug uptake and biological response.

An efficient therapeutic strategy involves choices about, not only of the drug, but also of the drug delivery system and the administration route. Furthermore, the development of target vesicular structures based on non-ionic surfactants seems to be an interesting way to improve the bioavailability of biologically-active substances.

This Special Issue aims to provide a collection of innovative approaches in drug delivery developed in the last decade and we see in vesicles non-ionic surfactants the main protagonists.

We invite you to contribute to this Special Issue with your research to highlight the potential of such systems for the development of nanomedicines.

Prof. Rita Muzzalupo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-ionic surfactant
  • niosomes
  • vesicles
  • drug delivery
  • target release
  • stimuli response vesicles

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

18 pages, 5363 KiB  
Article
Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells
by Cristina Ana Constantinescu, Elena Valeria Fuior, Daniela Rebleanu, Mariana Deleanu, Viorel Simion, Geanina Voicu, Virginie Escriou, Ileana Manduteanu, Maya Simionescu and Manuela Calin
Pharmaceutics 2019, 11(1), 47; https://doi.org/10.3390/pharmaceutics11010047 - 21 Jan 2019
Cited by 20 | Viewed by 5149
Abstract
: The progress in small-interfering RNA (siRNA) therapeutics depends on the development of suitable nanocarriers to perform specific and effective delivery to dysfunctional cells. In this paper, we questioned whether P-selectin, a cell adhesion molecule specifically expressed on the surface of activated endothelial [...] Read more.
: The progress in small-interfering RNA (siRNA) therapeutics depends on the development of suitable nanocarriers to perform specific and effective delivery to dysfunctional cells. In this paper, we questioned whether P-selectin, a cell adhesion molecule specifically expressed on the surface of activated endothelial cells (EC) could be employed as a target for nanotherapeutic intervention. To this purpose, we developed and characterized P-selectin targeted PEGylated cationic liposomes able to efficiently pack siRNA and to function as efficient vectors for siRNA delivery to tumour necrosis factor-α (TNF-α) activated EC. Targeted cationic liposomes were obtained by coupling a peptide with high affinity for P-selectin to a functionalized PEGylated phospholipid inserted in the liposomes’ bilayer (Psel-lipo). As control, scrambled peptide coupled cationic liposomes (Scr-lipo) were used. The lipoplexes obtained by complexation of Psel-lipo with siRNA (Psel-lipo/siRNA) were taken up specifically and at a higher extent by TNF-α activated b.End3 endothelial cells as compared to non-targeted Scr-lipo/siRNA. The Psel-lipo/siRNA delivered with high efficiency siRNA into the cells. The lipoplexes were functional as demonstrated by the down-regulation of the selected gene (GAPDH). The results demonstrate an effective targeted delivery of siRNA into cultured activated endothelial cells using P-selectin directed PEGylated cationic liposomes, which subsequently knock-down the desired gene. Full article
(This article belongs to the Special Issue Non-Ionic Surfactant Vesicles for Drug Delivery)
►▼ Show Figures

Graphical abstract

12 pages, 2363 KiB  
Article
A New Generation of Dihydropyridine Calcium Channel Blockers: Photostabilization of Liquid Formulations Using Nonionic Surfactants
by Giuseppina Ioele, Miyase Gözde Gündüz, Claudia Spatari, Michele De Luca, Fedora Grande and Gaetano Ragno
Pharmaceutics 2019, 11(1), 28; https://doi.org/10.3390/pharmaceutics11010028 - 11 Jan 2019
Cited by 10 | Viewed by 3735
Abstract
The stability profile of a new 1,4-dihydropyridine derivative (DHP), representative of a series with a hexahydroquinoline ring, was studied to design light-stable liquid formulations. This molecule, named M3, has been shown among the analogs to have a high capacity to block both L- [...] Read more.
The stability profile of a new 1,4-dihydropyridine derivative (DHP), representative of a series with a hexahydroquinoline ring, was studied to design light-stable liquid formulations. This molecule, named M3, has been shown among the analogs to have a high capacity to block both L- and T-type calcium channels. The ethanol solution of the drug was subjected to a photodegradation test, in accordance with standard rules. The concentrations of the drug and its byproducts were estimated using multivariate curve resolution, applied to the spectral data collected during the test. The improvement of both the photostability and water solubility of M3 was investigated by adding the surfactant polysorbate 20 in a 1:5 ratio to aqueous solutions of the drug. These formulations were exposed to stressing light in containers of bleu polyethylene terephthalate (PET), amber PET, and covered amber PET. The best results were obtained when using the covered amber PET container, reaching a degradation percentage of the drug less than 5% after 12 h under an irradiance power of 450 W/m2. The stability of the compound was compared to that of nimodipine (NIM) under the same conditions. Full article
(This article belongs to the Special Issue Non-Ionic Surfactant Vesicles for Drug Delivery)
►▼ Show Figures

Graphical abstract

15 pages, 5375 KiB  
Article
Brief Effect of a Small Hydrophobic Drug (Cinnarizine) on the Physicochemical Characterisation of Niosomes Produced by Thin-Film Hydration and Microfluidic Methods
by Li Key Yeo, Temidayo O. B. Olusanya, Cheng Shu Chaw and Amal Ali Elkordy
Pharmaceutics 2018, 10(4), 185; https://doi.org/10.3390/pharmaceutics10040185 - 13 Oct 2018
Cited by 53 | Viewed by 6529
Abstract
Novel niosomal formulations containing cinnarizine were developed to enhance its drug characteristics. In this work, niosomes (non-ionic surfactant vesicles) were prepared by conventional thin-film hydration (TFH) and microfluidic (MF) methods with sorbitan monostearate (Span® 60), cholesterol, and co-surfactants (Cremophor® ELP, Cremophor [...] Read more.
Novel niosomal formulations containing cinnarizine were developed to enhance its drug characteristics. In this work, niosomes (non-ionic surfactant vesicles) were prepared by conventional thin-film hydration (TFH) and microfluidic (MF) methods with sorbitan monostearate (Span® 60), cholesterol, and co-surfactants (Cremophor® ELP, Cremophor® RH40 and Solutol® HS15) as key excipients. The aim was to study the effect of cinnarizine on the characteristics of different niosomal formulations manufactured by using different methods. For effective targeted oral drug delivery, the efficacy of niosomes for therapeutic applications is correlated to their physiochemical properties. Niosome vesicles prepared were characterised using dynamic light scattering technique and the morphology of niosomes dispersion was characterised using optical microscopy. Dialysis was carried out to purify niosome suspensions to determine drug loading and drug release studies was performed to study the potential use of niosomal systems for cinnarizine. Full article
(This article belongs to the Special Issue Non-Ionic Surfactant Vesicles for Drug Delivery)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

16 pages, 4594 KiB  
Review
Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery
by Xuemei Ge, Minyan Wei, Suna He and Wei-En Yuan
Pharmaceutics 2019, 11(2), 55; https://doi.org/10.3390/pharmaceutics11020055 - 29 Jan 2019
Cited by 307 | Viewed by 18140
Abstract
Non-Ionic surfactant based vesicles, also known as niosomes, have attracted much attention in pharmaceutical fields due to their excellent behavior in encapsulating both hydrophilic and hydrophobic agents. In recent years, it has been discovered that these vesicles can improve the bioavailability of drugs, [...] Read more.
Non-Ionic surfactant based vesicles, also known as niosomes, have attracted much attention in pharmaceutical fields due to their excellent behavior in encapsulating both hydrophilic and hydrophobic agents. In recent years, it has been discovered that these vesicles can improve the bioavailability of drugs, and may function as a new strategy for delivering several typical of therapeutic agents, such as chemical drugs, protein drugs and gene materials with low toxicity and desired targeting efficiency. Compared with liposomes, niosomes are much more stable during the formulation process and storage. The required pharmacokinetic properties can be achieved by optimizing components or by surface modification. This novel delivery system is also easy to prepare and scale up with low production costs. In this paper, we summarize the structure, components, formulation methods, quality control of niosome and its applications in chemical drugs, protein drugs and gene delivery. Full article
(This article belongs to the Special Issue Non-Ionic Surfactant Vesicles for Drug Delivery)
►▼ Show Figures

Figure 1

24 pages, 2699 KiB  
Review
Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
by Santiago Grijalvo, Gustavo Puras, Jon Zárate, Myriam Sainz-Ramos, Nuseibah A. L. Qtaish, Tania López, Mohamed Mashal, Noha Attia, David Díaz Díaz, Ramon Pons, Eduardo Fernández, José Luis Pedraz and Ramon Eritja
Pharmaceutics 2019, 11(2), 50; https://doi.org/10.3390/pharmaceutics11020050 - 22 Jan 2019
Cited by 58 | Viewed by 6283
Abstract
Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly [...] Read more.
Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation and properties of the encapsulated hydrophobic or hydrophilic molecules. This review is aimed at providing recent information for using cationic niosomes for gene delivery purposes with particular emphasis on improving the transportation of antisense oligonucleotides (ASOs), small interference RNAs (siRNAs), aptamers and plasmids (pDNA). Full article
(This article belongs to the Special Issue Non-Ionic Surfactant Vesicles for Drug Delivery)
►▼ Show Figures

Graphical abstract

20 pages, 1440 KiB  
Review
Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy
by Elisabetta Mazzotta, Lorena Tavano and Rita Muzzalupo
Pharmaceutics 2018, 10(3), 150; https://doi.org/10.3390/pharmaceutics10030150 - 05 Sep 2018
Cited by 46 | Viewed by 5199
Abstract
Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its [...] Read more.
Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its advantageous combination with vesicular systems, recent investigations on thermo-sensitive vesicles useful for controlled drug delivery in cancer treatment are reported in this review. In particular, the influence of bilayer composition on the in vitro and in vivo behaviour of thermo-sensitive formulations currently under investigation have been extensively explored. Full article
(This article belongs to the Special Issue Non-Ionic Surfactant Vesicles for Drug Delivery)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop