Nanocarriers for Drug Delivery in Tissue Engineering

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1917

Special Issue Editors


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Guest Editor
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
Interests: drug delivery; micro/nano carriers; new technologies for drug carriers development; innovative drug carriers; biopolymers; liposomes; nanogels
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Guest Editor
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
Interests: drug delivery systems; nanomedicine; tissue engineering; microfluidics technology; lipid nanoparticles; liposomes; polyesters-based carriers

Special Issue Information

Dear Colleagues,

We are pleased to invite you to participate in a Special Issue of the Pharmaceutics journal entitled “Nanocarriers for Drug Delivery in Tissue Engineering”.

Despite good progress made recently by tissue engineering in developing synthetic extracellular matrices, the next big challenge will be the development of engineered nano-carriers that can be directly incorporated into 3D scaffolds to promote the assembly of an advanced microenvironment in which controlled or sustained delivery of growth factors or other bioactive molecules is achieved in a designed spatiotemporal fashion. Indeed, nano-carriers can advantageously modify the pharmacokinetic profile of bioactive molecules and control their concentration in specific target tissues. Moreover, nanocarrier inclusion within scaffolds can be used to reproduce more complex biological environments. On the other hand, issues concerning advanced processes and technologies to fabricate suitable nano-carriers in terms of relievable chemical-physical properties (e.g., low cytotoxicity and high encapsulation efficiency) or their functionalization with standardized protocols have become crucial for the future of tissue engineering.

This Special Issue aims to deepen nanocarrier manufacturing processes, their characterization, and embedding protocols to enhance and standardize local drug delivery within 3D scaffolds aimed at tissue engineering or regenerative medicine. The primary purpose of this Issue is to examine novel manufacturing processes for synthesizing advanced nanocarriers and their characterization, including morphological (TEM and SEM), granulometric (DLS and NTA), and kinetic analyses. Finally, cytotoxicity and potential biological effects on in vitro and in vivo 3D bioengineered models will also be the focus of this research topic.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

  • Development of new delivery nano-systems for tissue engineering
  • Strategies to improve the encapsulation efficiency of growth factors or bioactive molecules for tissue engineering protocols
  • Innovative manufacturing processes for nano-carrier production.

We look forward to receiving your contributions.

Prof. Dr. Giovanna Della Porta
Dr. Erwin Pavel Lamparelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • controlled release
  • growth factors encapsulation
  • Innovative nanoencapsulation techniques
  • tissue engineering
  • nanomedicine

Published Papers (1 paper)

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Review

24 pages, 7399 KiB  
Review
The Other Side of Plastics: Bioplastic-Based Nanoparticles for Drug Delivery Systems in the Brain
by Erwin Pavel Lamparelli, Marianna Marino, Marta Anna Szychlinska, Natalia Della Rocca, Maria Camilla Ciardulli, Pasqualina Scala, Raffaella D'Auria, Antonino Testa, Andrea Viggiano, Francesco Cappello, Rosaria Meccariello, Giovanna Della Porta and Antonietta Santoro
Pharmaceutics 2023, 15(11), 2549; https://doi.org/10.3390/pharmaceutics15112549 - 28 Oct 2023
Cited by 1 | Viewed by 1421
Abstract
Plastics have changed human lives, finding a broad range of applications from packaging to medical devices. However, plastics can degrade into microscopic forms known as micro- and nanoplastics, which have raised concerns about their accumulation in the environment but mainly about the potential [...] Read more.
Plastics have changed human lives, finding a broad range of applications from packaging to medical devices. However, plastics can degrade into microscopic forms known as micro- and nanoplastics, which have raised concerns about their accumulation in the environment but mainly about the potential risk to human health. Recently, biodegradable plastic materials have been introduced on the market. These polymers are biodegradable but also bioresorbable and, indeed, are fundamental tools for drug formulations, thanks to their transient ability to pass through biological barriers and concentrate in specific tissues. However, this “other side” of bioplastics raises concerns about their toxic potential, in the form of micro- and nanoparticles, due to easier and faster tissue accumulation, with unknown long-term biological effects. This review aims to provide an update on bioplastic-based particles by analyzing the advantages and drawbacks of their potential use as components of innovative formulations for brain diseases. However, a critical analysis of the literature indicates the need for further studies to assess the safety of bioplastic micro- and nanoparticles despite they appear as promising tools for several nanomedicine applications. Full article
(This article belongs to the Special Issue Nanocarriers for Drug Delivery in Tissue Engineering)
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