Novel Therapeutic Approaches for Neurodegenerative Diseases Treatment, 2nd Edition
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".
Deadline for manuscript submissions: closed (10 November 2023) | Viewed by 2439
Special Issue Editor
Interests: bioactive compounds; cell signaling; drug delivery; drug discovery; enzymology; high-throughput screening; metalloproteases; molecular pharmacology; nanoparticles; neuropeptides; neurodegenerative diseases; parkinson's disease; protein-protein interaction inhibitors; protein engineering; protein structure; protease inhibitors; protein folding and aggregation; substrate specificity; X-ray crystallography
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Special Issue Information
Dear Colleagues,
Neurodegenerative disorders are typically characterized by the progressive loss of specific populations of neurons in the brain. They can be classified according to a variety of primary clinical features and are associated with characteristic molecular abnormalities. The most common neurodegenerative disorders are amyloidoses, tauopathies, α-synucleinopathies, and TDP-43 proteinopathies. Nearly all of these disorders are associated with the accumulation of protein deposits and with alterations in normal proteostasis. Despite recent advances in the field, most of the molecular mechanisms involved in disease progression are not completely understood. However, since protein aggregation is a central event in neurological disorders, a variety of novel approaches have been focused on developing novel pharmacologically active molecules targeting this process. In addition, our understanding of amyloid structures has been boosted by recent advances in the field of structural biology and cryo-EM; these advances have facilitated the recent elucidation of a large number of high-resolution amyloid structures associated with neurodegeneration. Without a doubt, such ground-breaking discoveries will facilitate the structure-based design of novel, functional, and specific protein aggregation inhibitors. Additionally, there is an increasing focus on the utilization of nanomaterials as efficient drug delivery systems targeting neurodegenerative disorders.
The focus of this Special Issue is on the development and identification of novel molecules and therapeutic approaches dedicated to treating neurodegenerative diseases. The topics include (but are not limited to) the following: the design and development of novel protein-aggregation inhibitors; drug delivery using nanotechnology; and the development and characterization of pharmacologically active compounds targeting proteostasis and neurodegeneration.
Dr. Javier Garcia-Pardo
Guest Editor
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Keywords
- neurodegenerative diseases
- structure of amyloid fibrils
- protein aggregation
- Parkinson’s disease
- amyloidoses
- α-synucleinopathies
- tauopathies
- TDP-43 proteinopathies
- cell signaling
- drug discovery
- drug delivery
- nanotechnology
- high-throughput screening
- aggregation inhibitor
- protease inhibitor
- proteostasis
