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Pharmaceutics
Special Issues
Novel Drug Delivery Systems: Magnetic Gels
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Novel Drug Delivery Systems: Magnetic Gels

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 3552

Special Issue Editor

Dr. Carlos O. Amorim

E-Mail Website
Guest Editor
Physics Department & CICECO, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: nanomedicine; magnetic materials; nanomagnetism; magnetic hyperthermia; multifunctional materials

Special Issue Information

Dear Colleagues,

The lack of specificity in relation to drug delivery systems tends to result in inefficient therapeutic effectiveness and potentiates their possibly avoidable side effects. This is especially true in therapeutics such as chemotherapy where the side effects may lead to substantial suffering and greatly reduce survival rates.

The combination of hydrogels and functionalized magnetic nanoparticles into a single magnetic gel represents a truly promising approach to tackle the limitations of current drug delivery systems. The magnetic gels also present a huge multifunctional potential that does not only provide answers to several limitations of drug delivery, but also allows synergy with other therapeutics (such as magnetic hyperthermia) and enables simultaneous treatment diagnosis using a theranostics mindset.

In this Special Issue, authors are invited to submit their original research articles, reviews, or short communications which focus on the use of magnetic gels as novel drug delivery systems. Works focusing solely on the constituents of magnetic gels, namely gels and/or magnetic nanoparticles are also welcome.

Dr. Carlos O. Amorim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • drug delivery systems
  • magnetic gels
  • hydrogels
  • magnetic nanoparticles
  • theranostics
  • targeted therapy
  • chemotherapy
  • hyperthermia

Published Papers (2 papers)

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Research

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18 pages, 4577 KiB  
Article
Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin
by Sérgio R. S. Veloso, Eva S. Marta, Pedro V. Rodrigues, Cacilda Moura, Carlos O. Amorim, Vítor S. Amaral, Miguel A. Correa-Duarte and Elisabete M. S. Castanheira
Pharmaceutics 2023, 15(9), 2194; https://doi.org/10.3390/pharmaceutics15092194 - 24 Aug 2023
Cited by 2 | Viewed by 1653
Abstract
In this study, multicore-like iron oxide (Fe3O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures [...] Read more.
In this study, multicore-like iron oxide (Fe3O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures and displayed sizes of 20 ± 3 nm (Fe3O4) and 11 ± 2 nm (MnFe2O4). The Fe3O4 nanoparticles showed a higher saturation magnetization and heating efficiency compared with the MnFe2O4 nanoparticles. Functionalization with citrate and bovine serum albumin was found to improve the stability and modified surface properties. The nanoparticles were encapsulated in nanogels, and provided high drug encapsulation efficiencies (~70%) using doxorubicin as a model drug. The nanogels exhibited sustained drug release, with enhanced release under near-infrared (NIR) laser irradiation and acidic pH. The nanogels containing BSA-functionalized nanoparticles displayed improved sustained drug release at physiological pH, and the release kinetics followed a diffusion-controlled mechanism. These results demonstrate the potential of synthesized nanoparticles and nanogels for controlled drug delivery, offering opportunities for targeted and on-demand release in biomedical applications. Full article
(This article belongs to the Special Issue Novel Drug Delivery Systems: Magnetic Gels)
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Review

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16 pages, 2816 KiB  
Review
Magnetic Gels in Skin Cancer Treatment: A Review of Potential Applications in Diagnostics, Drug Delivery and Hyperthermia
by Marcos Luciano Bruschi and Glécilla Colombelli de Souza Nunes
Pharmaceutics 2023, 15(4), 1244; https://doi.org/10.3390/pharmaceutics15041244 - 14 Apr 2023
Cited by 1 | Viewed by 1435
Abstract
Skin cancer (SC) is affecting an increasing number of people worldwide. Its lesions affect mainly the most exposed regions of the skin. SC is classified into to main categories: non-melanoma (basal cell carcinoma of the epidermis and squamous cell carcinoma) and melanoma (the [...] Read more.
Skin cancer (SC) is affecting an increasing number of people worldwide. Its lesions affect mainly the most exposed regions of the skin. SC is classified into to main categories: non-melanoma (basal cell carcinoma of the epidermis and squamous cell carcinoma) and melanoma (the abnormal proliferation of melanocytes, which is rarer, more hazardous, and more deadly). Prevention and early diagnosis are important actions, and surgery is often considered. After the removal of cancerous lesions, the local administration of medicine can guarantee anticancer therapeutic action, rapid healing and the recovery of tissue, ensuring the absence of recurrence. Magnetic gels (MGs) have attracted increased attention regarding their pharmaceutical and biomedical applications. They are magnetic nanoparticles (e.g., iron oxide nanoparticles) dispersed in a polymeric matrix, which constitute adaptive systems under a magnetic field. MGs can combine magnetic susceptibility, high elasticity, and softness, and are thus useful platforms for diagnostics, drug delivery, and also for hyperthermia. This manuscript reviews MGs as a technological strategy for the treatment of SC. An overview of SC and the treatment, types, and methods of preparing MGs are discussed. Moreover, the applications of MGs in SC and their future perspectives are considered. The combination of polymeric gels and magnetic nanoparticles continues to be investigated, and new products must hit the market. Clinical trials and new products are expected, due to the important advantages of MGs. Full article
(This article belongs to the Special Issue Novel Drug Delivery Systems: Magnetic Gels)
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