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Pharmaceutics
Special Issues
Pharmaceutical Powders for Respiratory Drug Delivery
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Pharmaceutical Powders for Respiratory Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 864

Special Issue Editor

Prof. Dr. Winston Duo Wu

E-Mail Website
Guest Editor
Engineering Research Centre of Advanced Powder Technology (ERCAPT), School of Chemical and Environmental Engineering (SCEE), Soochow University, Suzhou 215123, China
Interests: spray (freeze) drying technology; particle science and engineering; respiratory drug delivery

Special Issue Information

Dear Colleagues,

Dry powder for respiratory drug delivery has attracted extensive attention in the field of innovative pharmaceutical product design. However, pulmonary and intranasal delivery of biologics, i.e., vaccines, therapeutic peptides and proteins, and high-dose active pharmaceutical ingredients, i.e., antibiotics, antibacterial and antiviral drugs, are still challenging. To tackle such problems, innovative strategies of formulation design, pharmaceutical process and engineering, as well as powder characterization methods, are urgently required. Moreover, investigation of the structure regulation and pulmonary/intranasal delivery performance of inhalable dry powder should be involved.

This Special Issue aims to highlight recent advances in the fabrication and characterization methods of pharmaceutical powders for respiratory drug delivery.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Quality-by-Design (QbD) strategies;
  • Innovative pharmaceutical process and engineering;
  • Advanced powder characterization method;
  • High-dose respiratory drug delivery;
  • Inhaled nanomedicines;
  • Inhaled vaccines of dry powder.

We look forward to receiving your contributions.

Prof. Dr. Winston Duo Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inhalable dry powder
  • high-dose formulation
  • pharmaceuticals process
  • powder technology
  • powder characterization
  • scale-up strategies
  • controlled release

Published Papers (1 paper)

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Research

20 pages, 7608 KiB  
Article
Development of Large Hollow Particles for Pulmonary Delivery of Cyclosporine A
by Yongpeng Huang, Hui Tang, Xiangyan Meng, Zitong Zhao, Yanli Liu, Dongxin Liu, Bo Chen and Zhiyun Zou
Pharmaceutics 2023, 15(9), 2204; https://doi.org/10.3390/pharmaceutics15092204 - 25 Aug 2023
Cited by 1 | Viewed by 669
Abstract
The purpose of this study was to prepare large hollow particles (LHPs) by spray drying for pulmonary delivery of cyclosporine A (CsA), using L-Leucine (LEU) and hydroxypropyl methylcellulose (HPMC) as excipients and ammonium bicarbonate (AB) as a porogen. The prepared LHPs were spherical [...] Read more.
The purpose of this study was to prepare large hollow particles (LHPs) by spray drying for pulmonary delivery of cyclosporine A (CsA), using L-Leucine (LEU) and hydroxypropyl methylcellulose (HPMC) as excipients and ammonium bicarbonate (AB) as a porogen. The prepared LHPs were spherical particles composed of both CsA and LEU on the surface and HPMC on the inner layer. The formulation of CsA-LEU-0.8HPMC-AB as typical LHPs showed excellent in vitro aerodynamic performance with a minimum mass median aerodynamic diameter (MMAD) of 1.15 μm. The solubility of CsA-LEU-0.8HPMC-AB was about 5.5-fold higher than that of raw CsA, and the dissolution of CsA-LEU-0.8HPMC-AB suggested that the drug was released within 1 h. The cell viability of the A549 cell line showed that CsA-LEU-0.8HPMC-AB was safe for delivering CsA to the lungs. In addition, inhalation administration of CsA-LEU-0.8HPMC-AB with the Cmax and AUC0–∞ increasing by about 2-fold and 2.8-fold compared with the oral administration of Neoral® could achieve therapeutic drug concentrations with lower systemic exposure and significantly improve the in vivo bioavailability of CsA. From these findings, the LHPs, with the advantage of avoiding alveolar macrophage clearance, could be a viable choice for delivering CsA by inhalation administration relative to oral administration. Full article
(This article belongs to the Special Issue Pharmaceutical Powders for Respiratory Drug Delivery)
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