Personalisation the Management of Inflammatory Diseases
Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 13614
Interests: analytical method development; pharmacokinetics; therapeutic drug monitoring; toxicology
In inflammatory diseases (ID) such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), pharmacotherapy should be personalized. ID treatment is complex, with highly different treatment modalities ranging from small-molecular anti-inflammatory drugs and corticosteroids to important developments such as monoclonal antibodies (mAbs). In the case of mAbs, an extra dimension is caused by the production of anti-drug antibodies, complicating the choice and dose of the drug. Evidence is emerging that drug choice and especially drug dosing should be personalized and target concentration is driven. Detailed pharmacological knowledge including pharmacogenetics, pharmacodynamics and concentration-effect relationships is essential for choosing the right drug, in the right dose, in the right administration form, at the right time, for each individual patient. We are pleased to invite you to make a contribution to this Special Issue that is devoted to the personalization of inflammatory disease management.
This Special Issue aims to give an overview of the clinical pharmacodynamic and pharmacokinetic considerations needed for tailoring treatment with the most common anti-inflammatory drugs for various classes of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Special interest is for the treatment of women with inflammatory diseases of reproductive age and for the emergence of concentration-targeted therapy using therapeutic drug monitoring in inflammatory diseases.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: clinical pharmacodynamics and pharmacokinetics of non-steroid and non-antibody classes of anti-inflammatory drugs, clinical pharmacodynamics and pharmacokinetics of monoclonal antibody anti-inflammatory drugs and the role of anti-drug antibodies, the role of therapeutic drug monitoring in inflammatory diseases, treatment of pregnant women with inflammatory diseases, treatment of inflammatory diseases in lactating women, treatment of children with inflammatory diseases.
We look forward to receiving your contributions.
Prof. Dr. Daniel J. Touw
Dr. Paola Mian
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- monoclonal antibody
- therapeutic drug monitoring
- anti-drug antibody
- anti-inflammatory drugs