Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.525
Journals
Pharmaceutics
Special Issues
Bioanalysis and Metabolomics (Volume II)
share announcement

Special Issue "Bioanalysis and Metabolomics (Volume II)"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".

Deadline for manuscript submissions: 31 August 2023 | Viewed by 2265

Special Issue Editors

Prof. Dr. Kwang-Hyeon Liu

E-Mail Website
Guest Editor
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea
Interests: drug metabolism; metabolomics; lipidomics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Hye Suk Lee

E-Mail Website
Guest Editor
College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Korea
Interests: bioanalysis; drug metabolism; pharmacokinetics; drug interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, techniques for analyzing endogenous and exogenous substances present in biological samples have been developed due to the development of analytical instruments that combine chromatography and mass spectrometry. As a result, as micro-analysis of drugs is possible, microdosing methods for studying the pharmacokinetics of drugs in humans through the administration of sub-therapeutic doses have been developed and applied in clinical trials. In addition, metabolomics techniques that target endogenous substances in biological samples have been developed, and various studies on biomarkers that can be used to diagnose the disease early and evaluate the efficacy of drugs have been actively conducted. This Special Issue aims to highlight current progress in bioanalysis related to drug metabolism and pharmacokinetics and drug- and disease-related metabolomics.

Prof. Dr. Kwang-Hyeon Liu
Prof. Dr. Hye Suk Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioanalysis
  • method validation
  • pharmacokinetics
  • metabolomics
  • lipidomics
  • biomarkers
  • mass spectrometry

Related Special Issue

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

get_app
Article
An Approach to Evaluate the Effective Cytoplasmic Concentration of Bioactive Agents Interacting with a Selected Intracellular Target Protein
by
Yuri V. Khramtsov
,
Alexey V. Ulasov
,
Andrey A. Rosenkranz
,
Tatiana A. Slastnikova
,
Tatiana N. Lupanova
,
Georgii P. Georgiev
and
Alexander S. Sobolev
Pharmaceutics 2023, 15(2), 324; https://doi.org/10.3390/pharmaceutics15020324 - 18 Jan 2023
Cited by 1 | Viewed by 762
Abstract
To compare the effectiveness of various bioactive agents reversibly acting within a cell on a target intracellular macromolecule, it is necessary to assess effective cytoplasmic concentrations of the delivered bioactive agents. In this work, based on a simple equilibrium model and the cellular [...] Read more.
To compare the effectiveness of various bioactive agents reversibly acting within a cell on a target intracellular macromolecule, it is necessary to assess effective cytoplasmic concentrations of the delivered bioactive agents. In this work, based on a simple equilibrium model and the cellular thermal shift assay (CETSA), an approach is proposed to assess effective concentrations of both a delivered bioactive agent and a target protein. This approach was tested by evaluating the average concentrations of nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated-protein 1 (Keap1) proteins in the cytoplasm for five different cell lines (Hepa1, MEF, RAW264.7, 3LL, and AML12) and comparing the results with known literature data. The proposed approach makes it possible to analyze both binary interactions and ternary competition systems; thus, it can have a wide application for the analysis of protein–protein or molecule–protein interactions in the cell. The concentrations of Nrf2 and Keap1 in the cell can be useful not only in analyzing the conditions for the activation of the Nrf2 system, but also for comparing the effectiveness of various drug delivery systems, where the delivered molecule is able to interact with Keap1. Full article
(This article belongs to the Special Issue Bioanalysis and Metabolomics (Volume II))
►▼ Show Figures

Figure 1

Review

Jump to: Research

get_app
Review
Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis
by
Atiqah Zaid
,
Norfarizah Hanim Hassan
,
Philip J. Marriott
and
Yong Foo Wong
Pharmaceutics 2023, 15(4), 1121; https://doi.org/10.3390/pharmaceutics15041121 - 31 Mar 2023
Viewed by 1167
Abstract
Over the last decades, comprehensive two-dimensional gas chromatography (GC×GC) has emerged as a significant separation tool for high-resolution analysis of disease-associated metabolites and pharmaceutically relevant molecules. This review highlights recent advances of GC×GC with different detection modalities for drug discovery and analysis, which [...] Read more.
Over the last decades, comprehensive two-dimensional gas chromatography (GC×GC) has emerged as a significant separation tool for high-resolution analysis of disease-associated metabolites and pharmaceutically relevant molecules. This review highlights recent advances of GC×GC with different detection modalities for drug discovery and analysis, which ideally improve the screening and identification of disease biomarkers, as well as monitoring of therapeutic responses to treatment in complex biological matrixes. Selected recent GC×GC applications that focus on such biomarkers and metabolite profiling of the effects of drug administration are covered. In particular, the technical overview of recent GC×GC implementation with hyphenation to the key mass spectrometry (MS) technologies that provide the benefit of enhanced separation dimension analysis with MS domain differentiation is discussed. We conclude by highlighting the challenges in GC×GC for drug discovery and development with perspectives on future trends. Full article
(This article belongs to the Special Issue Bioanalysis and Metabolomics (Volume II))
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop