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Special Issue "Antimicrobial Agents Based on Nanomaterials"

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A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 20 January 2024 | Viewed by 2339

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Special Issue Editors

Dr. Ting Du

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Guest Editor

State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China
Interests: hydrogel; antibacterial; wound healing

Dr. Zhiyong Song

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Guest Editor

College of Science, Huazhong Agricultural University, Wuhan 430070, China
Interests: antibacterial nanomaterials design; construction of stimulus-responsive nanodelivery systems and treatment of drug-resistant bacterial infections; nano-vaccine

Special Issue Information

Dear Colleagues,

This Special Issue is devoted to reporting the latest developments in nanomaterials, capable of combating microorganisms such as bacteria and viruses. Around the world, the surge in bacterial diseases is causing serious health threats and potential other problems. The emergence and global spread of bacterial resistance to currently available antibiotics highlights the urgent need for new alternative antibacterial agents. In recent years, the metal ion release and photodynamic and photothermal effects of nanomaterials have shown positive efficiency in eliminating bacterial resistance and proliferation. Nanomaterials with surface plasmon resonance, photocatalysis, structural complexity and optical properties have been used to control the release of metal ions, and generate reactive oxygen species and heat for antibacterial applications. The properties of nanomaterials provide an opportunity to explore and enhance their antibacterial activities for clinical applications. For this Special Issue, we invite authors to contribute original research or review articles on the application of nanomaterials as antimicrobial agents or for antimicrobial drug delivery.

Dr. Ting Du
Dr. Zhiyong Song
Guest Editors

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Keywords

nanomaterials
photodynamic
photothermal
antibacterial mechanism
biofilm

Published Papers (4 papers)

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Research

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Open AccessArticle

Fullerenes on a Nanodiamond Platform Demonstrate Antibacterial Activity with Low Cytotoxicity

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Pharmaceutics 2023, 15(7), 1984; https://doi.org/10.3390/pharmaceutics15071984 - 19 Jul 2023

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Abstract

Carbon nanoparticles with antimicrobial properties, such as fullerenes, can be distinguished among the promising means of combating pathogens characterized by resistance to commercial antibiotics. However, they have a number of limitations for their use in medicine. In particular, the insolubility of carbon nanoparticles in water leads to a low biocompatibility and especially strong aggregation when transferred to liquid media. To overcome the negative factors and enhance the action of fullerenes in an extended range of applications, for example, in antimicrobial photodynamic therapy, we created new water-soluble complexes containing, in addition to C60 fullerene, purified detonation nanodiamonds (AC960) and/or polyvinylpyrrolidone (PVP). The in vitro antibacterial activity and toxicity to human cells of the three-component complex C60+AC960+PVP were analyzed in comparison with binary C60+PVP and C60+AC960. All complexes showed a low toxicity to cultured human skin fibroblasts and ECV lines, as well as significant antimicrobial activity, which depend on the type of microorganisms exposed, the chemical composition of the complex, its dosage and exposure time. Complex C60+PVP+AC960 at a concentration of 175 µg/mL showed the most stable and pronounced inhibitory microbicidal/microbiostatic effect. Full article

(This article belongs to the Special Issue Antimicrobial Agents Based on Nanomaterials)

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Open AccessArticle

The Antibiofilm Effects of Antimony Tin Oxide Nanoparticles against Polymicrobial Biofilms of Uropathogenic Escherichia coli and Staphylococcus aureus

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Pharmaceutics 2023, 15(6), 1679; https://doi.org/10.3390/pharmaceutics15061679 - 08 Jun 2023

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Abstract

Biofilms are responsible for persistent or recurring microbial infections. Polymicrobial biofilms are prevalent in environmental and medical niches. Dual-species biofilms formed by Gram-negative uropathogenic Escherichia coli (UPEC) and Gram-positive Staphylococcus aureus are commonly found in urinary tract infection sites. Metal oxide nanoparticles (NPs) are widely studied for their antimicrobial and antibiofilm properties. We hypothesized that antimony-doped tin (IV) oxide (ATO) NPs, which contain a combination of antimony (Sb) and tin (Sn) oxides, are good antimicrobial candidates due to their large surface area. Thus, we investigated the antibiofilm and antivirulence properties of ATO NPs against single- and dual-species biofilms formed by UPEC and S. aureus. ATO NPs at 1 mg/mL significantly inhibited biofilm formation by UPEC, S. aureus, and dual-species biofilms and reduced their main virulence attributes, such as the cell surface hydrophobicity of UPEC and hemolysis of S. aureus and dual-species biofilms. Gene expression studies showed ATO NPs downregulated the hla gene in S. aureus, which is essential for hemolysin production and biofilm formation. Furthermore, toxicity assays with seed germination and Caenorhabditis elegans models confirmed the non-toxic nature of ATO NPs. These results suggest that ATO nanoparticles and their composites could be used to control persistent UPEC and S. aureus infections. Full article

(This article belongs to the Special Issue Antimicrobial Agents Based on Nanomaterials)

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Review

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Antimicrobial Activity of Selenium Nanoparticles (SeNPs) against Potentially Pathogenic Oral Microorganisms: A Scoping Review

Eulàlia Sans-Serramitjana

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Pharmaceutics 2023, 15(9), 2253; https://doi.org/10.3390/pharmaceutics15092253 - 31 Aug 2023

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Abstract

Biofilms are responsible for the most prevalent oral infections such as caries, periodontal disease, and pulp and periapical lesions, which affect the quality of life of people. Antibiotics have been widely used to treat these conditions as therapeutic and prophylactic compounds. However, due to the emergence of microbial resistance to antibiotics, there is an urgent need to develop and evaluate new antimicrobial agents. This scoping review offers an extensive and detailed synthesis of the potential role of selenium nanoparticles (SeNPs) in combating oral pathogens responsible for causing infectious diseases. A systematic search was conducted up until May 2022, encompassing the MEDLINE, Embase, Scopus, and Lilacs databases. We included studies focused on evaluating the antimicrobial efficacy of SeNPs on planktonic and biofilm forms and their side effects in in vitro studies. The selection process and data extraction were carried out by two researchers independently. A qualitative synthesis of the results was performed. A total of twenty-two articles were considered eligible for this scoping review. Most of the studies reported relevant antimicrobial efficacy against C. albicans, S. mutans, E. faecalis, and P. gingivalis, as well as effective antioxidant activity and limited toxicity. Further research is mandatory to critically assess the effectiveness of this alternative treatment in ex vivo and in vivo settings, with detailed information about SeNPs concentrations employed, their physicochemical properties, and the experimental conditions to provide enough evidence to address the construction and development of well-designed and safe protocols. Full article

(This article belongs to the Special Issue Antimicrobial Agents Based on Nanomaterials)

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Open AccessReview

An Overview of Stimuli-Responsive Intelligent Antibacterial Nanomaterials

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Pharmaceutics 2023, 15(8), 2113; https://doi.org/10.3390/pharmaceutics15082113 - 09 Aug 2023

Cited by 1 | Viewed by 512

Abstract

Drug-resistant bacteria and infectious diseases associated with biofilms pose a significant global health threat. The integration and advancement of nanotechnology in antibacterial research offer a promising avenue to combat bacterial resistance. Nanomaterials possess numerous advantages, such as customizable designs, adjustable shapes and sizes, and the ability to synergistically utilize multiple active components, allowing for precise targeting based on specific microenvironmental variations. They serve as a promising alternative to antibiotics with diverse medical applications. Here, we discuss the formation of bacterial resistance and antibacterial strategies, and focuses on utilizing the distinctive physicochemical properties of nanomaterials to achieve inherent antibacterial effects by investigating the mechanisms of bacterial resistance. Additionally, we discuss the advancements in developing intelligent nanoscale antibacterial agents that exhibit responsiveness to both endogenous and exogenous responsive stimuli. These nanomaterials hold potential for enhanced antibacterial efficacy by utilizing stimuli such as pH, temperature, light, or ultrasound. Finally, we provide a comprehensive outlook on the existing challenges and future clinical prospects, offering valuable insights for the development of safer and more effective antibacterial nanomaterials. Full article

(This article belongs to the Special Issue Antimicrobial Agents Based on Nanomaterials)

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Special Issue "Antimicrobial Agents Based on Nanomaterials"

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