Special Issue "Novel Polymeric Biomaterials for Tissue Engineering and Regenerative Medicine"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 30 September 2023 | Viewed by 596

Special Issue Editors

Departamento de Farmacia, Facultad de Química, Ciudad Universitaria, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Del. Coyoacán, Ciudad de México 04510, Mexico
Interests: films; nanoparticles; wound healing; blood–brain barrier; skin care
Special Issues, Collections and Topics in MDPI journals
Tecnologico de Monterrey, School of Engineering and Sciences, Mexico City Campus, C. Puente 222, Mexico City 14380, Mexico
Interests: nanoparticles; tissue engineering; control microbial biofilm; skin; aerogels
Special Issues, Collections and Topics in MDPI journals
Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico
Interests: skin physiology; skin diseases; wound healing; nanotechnology; wound dressings; burns; natural products; phytochemicals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

According to the WHO, noncommunicable diseases (NCDs) continue to represent 7 of the 10 leading causes of death globally, with an impact on 74% of all deaths worldwide, represented by 41 million people each year. The major NCDs are cardiovascular diseases (heart attacks and strokes), cancers, chronic respiratory diseases (chronic obstructive pulmonary disease and asthma), and diabetes. Cardiovascular diseases account for the highest mortality from NCDs, with 17.9 million deaths each year, followed by cancers with 9.3 million deaths, chronic respiratory diseases with 4.1 million deaths, and diabetes with 2.0 million deaths (including deaths from kidney disease caused by diabetes). The medical and surgical approach to NCDs continuously requires novel polymeric biomaterials for tissue engineering and regenerative medicine to provide timely and adequate interventions that reduce the level of deaths and, moreover, maintain an adequate quality of life for recovering patients. Biomaterials offer architectural frameworks that simulate the native extracellular matrix to encourage cell growth, tissue repair, and regeneration. Therefore, novel biopolymers are sought to fulfill adequate mechanical and biological functions. Tissue engineering is dedicated to assembling functional constructs that restore or maintain damaged tissues, and regenerative medicine is focused on developing and applying new treatments to regrow, repair, or replace damaged or diseased cells, organs, or tissues.

This Special Issue aims to consider research on novel polymeric biomaterials and their potential application in restoring or replacing cells, organs, or tissues.

We invite authors to contribute original research articles or review articles covering different topics of interest in novel polymeric biomaterials for tissue engineering and regenerative medicine, such as (i) different routes for obtaining new polymers for tissue engineering; (ii) characterization of new biomaterials; (iii) nanotechnology for drug delivery and gene therapy; (iv) films with multifunctional properties; (v) membranes as scaffolds; (vi) injectable, thermosensitive, self-healing hydrogels; (vii) microparticles for the transport of biological components; (viii) nanotechnology for drug delivery and gene therapy; (ix) biomechanical characterization of biomaterials; (x) simulation of the interaction of biomaterials with biological components; (xi) natural products, such as new biomaterials; (xii) preclinical and clinical trials; (xiii) pharmacoeconomics of biomaterials in tissue engineering and regenerative medicine; and (xiv) case studies of commercial biomaterials.

Dr. Gerardo Leyva-Gómez
Dr. María Luisa Del Prado-Audelo
Dr. Hernán Cortés
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer targeting
  • diabetes
  • cardiovascular diseases
  • chronic respiratory diseases
  • CNS targeting
  • biomolecule-based hydrogels
  • plant extract
  • phytotherapy
  • anti-inflammatory activity
  • cell signaling
  • biopharmaceutics
  • supramolecular self-assembly
  • drug delivery systems
  • biomaterials and polymer chemistry
  • novel drug delivery designs
  • biomedical applications
  • nanomedicine
  • tissue engineering
  • regenerative medicine

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


PEG 400:Trehalose Coating Enhances Curcumin-Loaded PLGA Nanoparticle Internalization in Neuronal Cells
Pharmaceutics 2023, 15(6), 1594; https://doi.org/10.3390/pharmaceutics15061594 - 25 May 2023
Viewed by 309
This work proposes a combination of polyethylene glycol 400 (PEG) and trehalose as a surface modification approach to enhance PLGA-based nanoparticles as a drug carrier for neurons. PEG improves nanoparticles’ hydrophilicity, and trehalose enhances the nanoparticle’s cellular internalization by inducing a more auspicious [...] Read more.
This work proposes a combination of polyethylene glycol 400 (PEG) and trehalose as a surface modification approach to enhance PLGA-based nanoparticles as a drug carrier for neurons. PEG improves nanoparticles’ hydrophilicity, and trehalose enhances the nanoparticle’s cellular internalization by inducing a more auspicious microenvironment based on inhibiting cell surface receptor denaturation. To optimize the nanoprecipitation process, a central composite design was performed; nanoparticles were adsorbed with PEG and trehalose. PLGA nanoparticles with diameters smaller than 200 nm were produced, and the coating process did not considerably increase their size. Nanoparticles entrapped curcumin, and their release profile was determined. The nanoparticles presented a curcumin entrapment efficiency of over 40%, and coated nanoparticles reached 60% of curcumin release in two weeks. MTT tests and curcumin fluorescence, with confocal imaging, were used to assess nanoparticle cytotoxicity and cell internalization in SH-SY5Y cells. Free curcumin 80 µM depleted the cell survival to 13% at 72 h. Contrariwise, PEG:Trehalose-coated curcumin-loaded and non-loaded nanoparticles preserved cell survival at 76% and 79% under the same conditions, respectively. Cells incubated with 100 µM curcumin or curcumin nanoparticles for 1 h exhibited 13.4% and 14.84% of curcumin’s fluorescence, respectively. Moreover, cells exposed to 100 µM curcumin in PEG:Trehalose-coated nanoparticles for 1 h presented 28% fluorescence. In conclusion, PEG:Trehalose-adsorbed nanoparticles smaller than 200 nm exhibited suitable neural cytotoxicity and increased cell internalization proficiency. Full article
Show Figures

Graphical abstract

Back to TopTop