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Pharmaceutics
Special Issues
Novel Preclinical Drug Formulation and Delivery Approaches: Developments and Challenges
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Special Issue "Novel Preclinical Drug Formulation and Delivery Approaches: Developments and Challenges"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Clinical Pharmaceutics".

Deadline for manuscript submissions: 20 October 2023 | Viewed by 1008

Special Issue Editor

Dr. Anroop Nair

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia
Interests: drug delivery; nanoformulations; drug targeting; film-based formulations; pharmacokinetics

Special Issue Information

Dear Colleagues,

Developing a new chemical entity into a pharmaceutically acceptable formulation involves numerous critically validated procedures across both preclinical and clinical investigations. As a part of the drug discovery and development program, preclinical formulations and various drug delivery approaches are being actively developed to improve the physicochemical properties and in vivo exposure of drugs to advance their pharmacodynamic and pharmacokinetic properties. Rapid advancement is anticipated in areas such as digital technology, genetics, and novel materials, and the implementation of novel technologies such as 3D printing will be of major importance in the development of stable, biopharmaceutically suitable preclinical formulations. The application of Design of Experiments (DoE), Process Analytical Technology (PAT) and Artificial Neural Networks (ANNs) has been utilized in exploring the critical process parameters that can significantly influence the quality and performance characteristics of pharmaceutical drug products.

This Special Issue aims to highlight recent research or reviews with an emphasis on the recent developments in various preclinical drug formulations or delivery systems. The authors are welcome to contribute articles related to preformulation studies or drug delivery systems, irrespective of the route of administration.

Dr. Anroop Nair
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • drug targeting
  • 3D printing
  • formulation development
  • nanotechnology
  • nanocarriers
  • hydrogels
  • film
  • self-assembled nanomicelles
  • drug solubility
  • drug release kinetics
  • dissolution
  • bioavailability
  • drug stability

Published Papers (1 paper)

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Research

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Article
Injectable pH and Thermo-Responsive Hydrogel Scaffold with Enhanced Osteogenic Differentiation of Preosteoblasts for Bone Regeneration
by
Jasmine L. King
,
Roopali Shrivastava
,
Pooja D. Shah
,
Panita Maturavongsadit
and
Soumya Rahima Benhabbour
Pharmaceutics 2023, 15(9), 2270; https://doi.org/10.3390/pharmaceutics15092270 - 02 Sep 2023
Viewed by 355
Abstract
Bone fractures are common in the geriatric population and pose a great economic burden worldwide. While traditional methods for repairing bone defects have primarily been autografts, there are several drawbacks limiting its use. Bone graft substitutes have been used as alternative strategies to [...] Read more.
Bone fractures are common in the geriatric population and pose a great economic burden worldwide. While traditional methods for repairing bone defects have primarily been autografts, there are several drawbacks limiting its use. Bone graft substitutes have been used as alternative strategies to improve bone healing. However, there remain several impediments to achieving the desired healing outcomes. Injectable hydrogels have become attractive scaffold materials for bone regeneration, given their high performance in filling irregularly sized bone defects and their ability to encapsulate cells and bioactive molecules and mimic the native ECM of bone. We investigated the use of an injectable chitosan-based hydrogel scaffold to promote the differentiation of preosteoblasts in vitro. The hydrogels were characterized by evaluating cell homogeneity, cell viability, rheological and mechanical properties, and differentiation ability of preosteoblasts in hydrogel scaffolds. Cell-laden hydrogel scaffolds exhibited shear thinning behavior and the ability to maintain shape fidelity after injection. The CNC-CS hydrogels exhibited higher mechanical strength and significantly upregulated the osteogenic activity and differentiation of preosteoblasts, as shown by ALP activity assays and histological analysis of hydrogel scaffolds. These results suggest that this injectable hydrogel is suitable for cell survival, can promote osteogenic differentiation of preosteoblasts, and structurally support new bone growth. Full article
(This article belongs to the Special Issue Novel Preclinical Drug Formulation and Delivery Approaches: Developments and Challenges)
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