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6.9
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Pharmaceutics
Special Issues
Nanotechnology for Drug and Vaccine Delivery
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Nanotechnology for Drug and Vaccine Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (1 July 2023) | Viewed by 4219

Special Issue Editor

Dr. Jie Tang

E-Mail Website
Guest Editor
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane 4072, Australia
Interests: nanomaterials; gene delivery; adjuvant; vaccine; cancer treatment; cancer immunotherapy; mucosal delivery

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to a Special Issue of Pharmaceutics entitled, “Nanotechnology for Drug and Vaccine Delivery”. Nanotechnology-based delivery strategies offer important advantages over conventional delivery platforms for therapeutics and vaccines.

This Special Issue aims to cover applications of nanotechnology in the advancement of drugs, vaccines, and targeted delivery systems.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: the design and evaluation of nanoparticle-based delivery systems for chemotherapeutics, proteins, and genes (siRNA, DNA, and mRNA), and their applications in vaccination, cancer therapy, antimicrobial and antiviral activities, would healing, or tissue regeneration.

I look forward to receiving your contributions.

Dr. Jie Tang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticle
  • vaccine delivery
  • cancer treatment
  • vaccine
  • anti-infection
  • gene delivery
  • mRNA
  • adjuvant
  • immune response

Published Papers (2 papers)

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Research

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10 pages, 2754 KiB  
Article
Self-Assembled Ru(II)-Coumarin Complexes for Selective Cell Membrane Imaging
by Jiyin Liu, Xiaochun Xie, Junna Lu, Yi He, Dan Shao and Fangman Chen
Pharmaceutics 2022, 14(11), 2284; https://doi.org/10.3390/pharmaceutics14112284 - 25 Oct 2022
Cited by 3 | Viewed by 1110
Abstract
The cell membrane, as the protecting frontier of cells, is closely related to crucial biological behaviors including cell growth, death, and division. Lots of fluorescent probes have been fabricated to monitor cell membranes due to their simplicity and intuitiveness. However, the efficiency of [...] Read more.
The cell membrane, as the protecting frontier of cells, is closely related to crucial biological behaviors including cell growth, death, and division. Lots of fluorescent probes have been fabricated to monitor cell membranes due to their simplicity and intuitiveness. However, the efficiency of those traditional probes has been limited by their susceptibility to photobleaching and poor water solubility. In this study, we have reported Ru(II)-coumarin complexes consisting of ruthenium, 1,10-phenanthroline, and coumarin 6 to further form self-assembled nanoprobes, for cell membrane targeting and imaging. The fluorescent property could be switchable from red to green through the dynamic disassembly of nanoprobes. Compared with commercial Dil, biocompatible nanoprobes exhibited superior stability for long-term cell imaging, along with remarkedly reduced background interference. Therefore, our self-assembled nanoprobe provides a powerful solution for investigating lipid trafficking with optical imaging. Full article
(This article belongs to the Special Issue Nanotechnology for Drug and Vaccine Delivery)
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Review

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18 pages, 2060 KiB  
Review
Recent Advances and Innovations in the Preparation and Purification of In Vitro-Transcribed-mRNA-Based Molecules
by Jingjing Zhang, Yuheng Liu, Chao Li, Qin Xiao, Dandan Zhang, Yang Chen, Joseph Rosenecker, Xiaoyan Ding and Shan Guan
Pharmaceutics 2023, 15(9), 2182; https://doi.org/10.3390/pharmaceutics15092182 - 23 Aug 2023
Cited by 1 | Viewed by 2514
Abstract
The coronavirus disease 2019 (COVID-19) pandemic poses a disruptive impact on public health and the global economy. Fortunately, the development of COVID-19 vaccines based on in vitro-transcribed messenger RNA (IVT mRNA) has been a breakthrough in medical history, benefiting billions of people with [...] Read more.
The coronavirus disease 2019 (COVID-19) pandemic poses a disruptive impact on public health and the global economy. Fortunately, the development of COVID-19 vaccines based on in vitro-transcribed messenger RNA (IVT mRNA) has been a breakthrough in medical history, benefiting billions of people with its high effectiveness, safety profile, and ease of large-scale production. This success is the result of decades of continuous RNA research, which has led to significant improvements in the stability and expression level of IVT mRNA through various approaches such as sequence optimization and improved preparation processes. IVT mRNA sequence optimization has been shown to have a positive effect on enhancing the mRNA expression level. The innovation of IVT mRNA purification technology is also indispensable, as the purity of IVT mRNA directly affects the success of downstream vaccine preparation processes and the potential for inducing unwanted side effects in therapeutic applications. Despite the progress made, challenges related to IVT mRNA sequence design and purification still require further attention to enhance the quality of IVT mRNA in the future. In this review, we discuss the latest innovative progress in IVT mRNA design and purification to further improve its clinical efficacy. Full article
(This article belongs to the Special Issue Nanotechnology for Drug and Vaccine Delivery)
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