Recent Advances Using Enhancement Strategies and Technologies for Topical Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2943

Special Issue Editors

Laboratory of Food, Drugs, and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Brasilia 70910-900, DF, Brazil
Interests: topical drug delivery; minimally invasive drug delivery; iontophoresis; development of innovative formulations; nanoformulations; novel biological barrier models
Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, Brasília 70910-900, Brazil
Interests: nanotechnology; topical delivery; targeted delivery; iontophoresis; skin; dermatological

Special Issue Information

Dear Colleagues,

Pharmaceutical technology has been devoted to developing strategies and technologies to enhance the amount of drug permeating through external tissues such as the skin, eyes, nails, vaginal and buccal cavity. As accessible tissues, these body parts have inherent protective physiological functions and are natural barriers for drug penetration. For a long time, technological approaches have focused on using formulations, designs and excipients for circumventing such protective functions, e.g., increasing formulation residence time, consequently enhancing drug penetration amounts, or deliberately altering the barrier function of these tissues. Significant progress has been made over the years, specifically applying drug delivery nano systems that can have multiple mechanisms for enhancing drug delivery. In addition, traditional technologies used for topical drug delivery enhancement have been evaluated for other purposes, e.g., improving gene transfection efficiency and others.

This Special Issue aims to reunite recent research studies that represent advancements achieved with the use of enhancement strategies and technologies for drug delivery or for the development of the technology itself, possibly opening novel possibilities for therapies and applications. We invite articles on all aspects of improved topical drug delivery, with an emphasis on formulation strategy, performance analysis or on the use of physical enhancement technologies and its applications.

We look forward to your reply.

Dr. Taís Gratieri
Prof. Dr. Guilherme M. Gelfuso
Guest Editors

Manuscript Submission Information

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Published Papers (1 paper)

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Review

20 pages, 2695 KiB  
Review
Methodologies to Evaluate the Hair Follicle-Targeted Drug Delivery Provided by Nanoparticles
by Maíra N. Pereira, Luma L. Nogueira, Marcilio Cunha-Filho, Tais Gratieri and Guilherme M. Gelfuso
Pharmaceutics 2023, 15(7), 2002; https://doi.org/10.3390/pharmaceutics15072002 - 21 Jul 2023
Cited by 4 | Viewed by 2698
Abstract
Nanotechnology has been investigated for treatments of hair follicle disorders mainly because of the natural accumulation of solid nanoparticles in the follicular openings following a topical application, which provides a drug “targeting effect”. Despite the promising results regarding the therapeutic efficacy of topically [...] Read more.
Nanotechnology has been investigated for treatments of hair follicle disorders mainly because of the natural accumulation of solid nanoparticles in the follicular openings following a topical application, which provides a drug “targeting effect”. Despite the promising results regarding the therapeutic efficacy of topically applied nanoparticles, the literature has often presented controversial results regarding the targeting of hair follicle potential of nanoformulations. A closer look at the published works shows that study parameters such as the type of skin model, skin sections analyzed, employed controls, or even the extraction methodologies differ to a great extent among the studies, producing either unreliable results or precluding comparisons altogether. Hence, the present study proposes to review different skin models and methods for quantitative and qualitative analysis of follicular penetration of nano-entrapped drugs and their influence on the obtained results, as a way of providing more coherent study protocols for the intended application. Full article
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