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Special Issue "Functional Biomaterials for Biomedical Applications"

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Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA
Interests: translational nanomedicine; nanofabricated drug delivery systems; ocular drug delivery; ocular nanomedicine

Special Issue Information

Dear Colleagues,

Biomaterials with specific immuno- and inflammation modulatory attributes in synergy with therapeutics, biologics, and tissue systems are extremely useful within clinical translation. Current biomaterials are mainly developed as drug carriers or inert scaffolds in tissue culture systems without any intrinsic functional attributes.

This Special Issue aims to introduce high-impact research articles focused on the development of functional biomaterials for specific disease therapy, drug delivery, and innate immune and inflammation modulatory systems. This Special Issue will compile high-impact research articles that guide the development of next-generation functional biomaterials.

Dr. Ghanashyam S. Acharya
Guest Editor

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Keywords

functional biomaterials
anti-inflammatory
antifibrotic
antiangiogenic
wound healing
fibrosis

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Research

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Open AccessArticle

Demonstrating the In Vitro and In Situ Antimicrobial Activity of Oxide Mineral Microspheres: An Innovative Technology to Be Incorporated into Porous and Nonporous Materials

and

Pharmaceutics 2023, 15(4), 1261; https://doi.org/10.3390/pharmaceutics15041261 - 17 Apr 2023

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Abstract

The antimicrobial activity of surfaces treated with zinc and/or magnesium mineral oxide microspheres is a patented technology that has been demonstrated in vitro against bacteria and viruses. This study aims to evaluate the efficiency and sustainability of the technology in vitro, under simulation-of-use conditions, and in situ. The tests were undertaken in vitro according to the ISO 22196:2011, ISO 20473:2013, and NF S90-700:2019 standards with adapted parameters. Simulation-of-use tests evaluated the robustness of the activity under worst-case scenarios. The in situ tests were conducted on high-touch surfaces. The in vitro results show efficient antimicrobial activity against referenced strains with a log reduction of >2. The sustainability of this effect was time-dependent and detected at lower temperatures (20 ± 2.5 °C) and humidity (46%) conditions for variable inoculum concentrations and contact times. The simulation of use proved the microsphere’s efficiency under harsh mechanical and chemical tests. The in situ studies showed a higher than 90% reduction in CFU/25 cm² per treated surface versus the untreated surfaces, reaching a targeted value of <50 CFU/cm². Mineral oxide microspheres can be incorporated into unlimited surface types, including medical devices, to efficiently and sustainably prevent microbial contamination. Full article

(This article belongs to the Special Issue Functional Biomaterials for Biomedical Applications)

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Revolutionizing Drug Delivery and Therapeutics: The Biomedical Applications of Conductive Polymers and Composites-Based Systems

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Pharmaceutics 2023, 15(4), 1204; https://doi.org/10.3390/pharmaceutics15041204 - 10 Apr 2023

Cited by 1 | Viewed by 703

Abstract

The first conductive polymers (CPs) were developed during the 1970s as a unique class of organic substances with properties that are electrically and optically comparable to those of inorganic semiconductors and metals while also exhibiting the desirable traits of conventional polymers. CPs have become a subject of intensive research due to their exceptional qualities, such as high mechanical and optical properties, tunable electrical characteristics, ease of synthesis and fabrication, and higher environmental stability than traditional inorganic materials. Although conducting polymers have several limitations in their pure state, coupling with other materials helps overcome these drawbacks. Owing to the fact that various types of tissues are responsive to stimuli and electrical fields has made these smart biomaterials attractive for a range of medical and biological applications. For various applications, including the delivery of drugs, biosensors, biomedical implants, and tissue engineering, electrical CPs and composites have attracted significant interest in both research and industry. These bimodalities can be programmed to respond to both internal and external stimuli. Additionally, these smart biomaterials have the ability to deliver drugs in various concentrations and at an extensive range. This review briefly discusses the commonly used CPs, composites, and their synthesis processes. Further highlights the importance of these materials in drug delivery along with their applicability in various delivery systems. Full article

(This article belongs to the Special Issue Functional Biomaterials for Biomedical Applications)

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Special Issue "Functional Biomaterials for Biomedical Applications"

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