Special Issue "Multicomponent Solid Forms as Modifying Agents for Drugs with Solubility Problems"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 499

Special Issue Editors

Instituto de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Circuito Exterior S/N, 15 C.P. 04510, Coyoacán, Ciudad de México, México
Interests: supramolecular chemistry; crystal engineering; medicinal chemistry; metallopharmaceuticals, green chemistry
Special Issues, Collections and Topics in MDPI journals
Red de Apoyo a la Investigación, Coordinación de la Investigación Científica-UNAM, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Ciudad de Mexico C.P. 14000, Mexico
Interests: coamorphous; pharmaceutical binary eutectics mixtures; mechanochemical reactions; cocrystals; crystal engineering
Dr. Viviana Reyes-Márquez
E-Mail Website
Guest Editor
Departamento de Ciencias Químico-Biológicas, Universidad de Sonora, Luis Encinas y Rosales S/N, C.P. 83000, Hermosillo, Sonora, México
Interests: supramolecular chemistry; crystal engineering; molecular recognition; sensing

Special Issue Information

Dear Colleagues,

The formation of solid multicomponent pharmaceutical forms has become very relevant in recent years because a drug's physicochemical and biological properties can be easily and directly modified without it being covalently modified. The following may be relevant within the wide variety of multicomponent forms that can be obtained: cocrystals/salts, coamorphous, and eutectic mixtures.

Although significant progress has been made in developing methods to produce these multicomponent solid forms, finding efficient and easy-to-perform preparation methods still represents a challenge; given their many possible applications, there is a growing need to use these solid forms as modifying agents for drugs with solubility problems.

Thus, this Special Issue aims to contribute to the discussion of advances in the understanding of methods for obtaining multicomponent pharmaceutical forms with the main goal of altering the solubility properties of drugs that exhibit this problem.

This call for papers is open for both articles and reviews.

Prof. Dr. David Morales-Morales
Dr. Juan Manuel Germán-Acacio
Dr. Viviana Reyes-Márquez
Guest Editors

Manuscript Submission Information

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  • cocrystals
  • multicomponent salts
  • ionic cocrystals
  • coamorphous
  • eutectic mixtures
  • polymorphs of cocrystals

Published Papers (1 paper)

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Abiraterone Acetate Complexes with Biometals: Synthesis, Characterization in Solid and Solution, and the Nature of Chemical Bonding
Pharmaceutics 2023, 15(9), 2180; https://doi.org/10.3390/pharmaceutics15092180 - 23 Aug 2023
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Abiraterone acetate (AbirAc) is the most used steroidal therapeutic agent for treatment of prostate cancer. The mainly hydrophobic molecular surface of AbirAc results in its poor solubility and plays an important role for retention of abiraterone in the cavity of the receptor formed [...] Read more.
Abiraterone acetate (AbirAc) is the most used steroidal therapeutic agent for treatment of prostate cancer. The mainly hydrophobic molecular surface of AbirAc results in its poor solubility and plays an important role for retention of abiraterone in the cavity of the receptor formed by peptide chains and heme fragments. In order to evaluate the hydrolytic stability of AbirAc, to modify its solubility by formation of new solid forms and to model bonding of this medication with the heme, a series of d-metal complexes with AbirAc was obtained. AbirAc remains stable in water, acetonitrile, tetrahydrofuran, and ethanol, and readily interacts with dications as a terminal ligand to create discrete complexes, including [FePC(AbirAc)2] and [ZnTPP(AbirAc)] (H2PC = phthalocyanine and H2TPP = 5,10,15,20-tetraphenylporphyrine) models for ligand–receptor bonding. In reactions with silver(I) nitrate, AbirAc acts as a bridge ligand. Energies of chemical bonding between AbirAc and these cations vary from 97 to 235 kJ mol−1 and exceed those between metal atoms and water molecules. This can be indicative of the ability of abiraterone to replace solvent molecules in the coordination sphere of biometals in living cells, although the model [ZnTPP] complex remains stable in CDCl3, CD2Cl2, and 1,1,2,2-tetrachloroethane-d2 solvents and decomposes in polar dimethylsulfoxide-d6 and methanol-d4 solvents, as follows from the 1H DOSY spectra. Dynamics of its behavior in 1,1,2,2-tetrachloroethane-d2 were studied by ROESY and NMR spectra. Full article
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