Special Issue "Self-Emulsifying Systems for Bioactive Compounds Delivery and Pharmaceutical Applications"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 20 January 2024 | Viewed by 599

Special Issue Editor

Department of Pharmacy, State University of Maringa, Maringa, Brazil
Interests: drug delivery systems; buccal drug administration; smart materials; biopharmaceutics; nanotechnology; biopolymers; biocompatible materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Self-emulsifying drug delivery systems (SEDDS) can improve the poor water solubility of many active pharmaceutical ingredients, from natural or synthetic origin, and resulting in increased absorption and biological availability. SEDDS systems are commonly composed of an isotropic mixture of oils, surfactants, and co-solvents. When they come into contact with the aqueous medium, they can form emulsion systems. Their physicochemical characteristics and self-emulsification ability are dependent on parameters of formulation, such as surfactant amount, oil/surfactant ratio, system polarity, droplet charge, and size and charge. Over the last few decades, many SEDDS formulations have been proposed and investigated for pharmaceutical applications. A wide variety of oils, solvents, co-solvents, surfactants, drugs, and technologies have been used to obtain self-emulsifying formulations to be administered using different routes aiming at controlled drug delivery and improved drug bioavailability.

This Special Issue highlights recent advances in self-emulsifying systems for the delivery of compounds of natural and/or synthetic origin, and also considering pharmaceutical applications. Manuscripts covering controlled drug release, including development of formulations and investigations of physicochemical and pharmaceutical properties of SEDDS are welcome. We invite articles on all aspects of research in this field, aiming to improve the scientific knowledge and the clinical applications.

Prof. Dr. Marcos Luciano Bruschi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery
  • pharmaceutical systems
  • self-emulsifying drug delivery system
  • SEDDS
  • modified release
  • technology
  • emulsion systems

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
Development of Environmentally Responsive Self-Emulsifying System Containing Copaiba Oil-Resin for Leishmaniasis Oral Treatment
Pharmaceutics 2023, 15(8), 2127; https://doi.org/10.3390/pharmaceutics15082127 - 12 Aug 2023
Viewed by 410
Abstract
Leishmaniasis is a disease caused by protozoa species of the Leishmania genus, and the current treatments face several difficulties and obstacles. Most anti-leishmanial drugs are administered intravenously, showing many side effects and drug resistance. The discovery of new anti-leishmanial compounds and the development [...] Read more.
Leishmaniasis is a disease caused by protozoa species of the Leishmania genus, and the current treatments face several difficulties and obstacles. Most anti-leishmanial drugs are administered intravenously, showing many side effects and drug resistance. The discovery of new anti-leishmanial compounds and the development of new pharmaceutical systems for more efficient and safer treatments are necessary. Copaiba oil-resin (CO) has been shown to be a promising natural compound against leishmaniasis. However, CO displays poor aqueous solubility and bioavailability. Self-emulsifying drug delivery systems (SEDDS) can provide platforms for release of hydrophobic compounds in the gastrointestinal tract, improving their aqueous solubilization, absorption and bioavailability. Therefore, the present work aimed to develop SEDDS containing CO and Soluplus® surfactant for the oral treatment of leishmaniasis. The design of the systems was accomplished using ternary phase diagrams. Emulsification and dispersion time tests were used to investigate the emulsification process in gastric and intestinal environments. The formulations were nanostructured and improved the CO solubilization. Their in vitro antiproliferative activity against promastigote forms of L. amazonensis and L. infantum, and low in vitro cytotoxicity against macrophages were also observed. More studies are necessary to determine effectiveness of SOL in these systems, which can be candidates for further pharmacokinetics and in vivo investigations. Full article
Show Figures

Figure 1

Back to TopTop