Special Issue "Formulation and Delivery of Traditional Medicines and Natural Products"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 710

Special Issue Editors

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, MS 2-35F, 8613-114 Street, Edmonton, AB, Canada
Interests: pharmacokinetics; chirality; drug interactions; formulation and drug delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Arunporn Itharat
E-Mail Website
Guest Editor
Head of Department of Applied Thai Traditional Medicine, Faculty of Medicine and Director of Center of Excellence in Applied Thai Traditional Medicine Research, Thammasat University, Khlong Nueng, Khlong Luang, Pathum Thani 12120, Thailand
Interests: pharmacognosy; Thai traditional medicine; natural products; flavonoids; stilbenes; microemulsions; topical delivery

Special Issue Information

Dear Colleagues,

Traditional medicines and natural products from plant and animal sources require pharmaceutic formulation techniques and understanding of disposition able to overcome barriers, using carriers for bioavailability, solubility and stability issues and the possibility of formulating using delivery systems with controlled release rates. On these bases, traditional medicines and natural products and their dosage forms can represent effective therapeutic platforms for disease. The active molecules need to be formulated to achieve optimal efficacy. Most of the applied techniques include robust analytical method development and the study of delivery systems.

This Special Issue will cover different aspects of the delivery and disposition of traditional medicines and natural products as a means to control or modify the release of natural substances in traditional, contemporary and advanced delivery systems. Since clinical efficacies and toxicities have been reported to be improved by the formulation of the bioavailability of traditional medicines and natural products, release kinetics, stability concerns, taste masking, and overcoming natural barriers including the skin will be discussed.

Prof. Dr. Neal M. Davies
Dr. Arunporn Itharat
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • solubility
  • microencapsulation
  • hydrogel patch
  • coacervation
  • nanoparticles
  • in silico
  • lipid formulation
  • microemulsion
  • microspheres
  • microparticles
  • microcapsules
  • nanoemulsion
  • polymeric drug delivery systems
  • topical delivery

Published Papers (1 paper)

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Research

Article
Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release
Pharmaceutics 2023, 15(6), 1592; https://doi.org/10.3390/pharmaceutics15061592 - 25 May 2023
Viewed by 358
Abstract
Luteolin (LUT) is a flavonoid found in several edible and medicinal plants. It is recognized for its biological activities such as antioxidant, anti-inflammatory, neuroprotective, and antitumor effects. However, the limited water solubility of LUT leads to poor absorption after oral administration. Nanoencapsulation may [...] Read more.
Luteolin (LUT) is a flavonoid found in several edible and medicinal plants. It is recognized for its biological activities such as antioxidant, anti-inflammatory, neuroprotective, and antitumor effects. However, the limited water solubility of LUT leads to poor absorption after oral administration. Nanoencapsulation may improve the solubility of LUT. Nanoemulsions (NE) were selected for the encapsulation of LUT due to their biodegradability, stability, and ability to control drug release. In this work, chitosan (Ch)-based NE was developed to encapsulate luteolin (NECh-LUT). A 23 factorial design was built to obtain a formulation with optimized amounts of oil, water, and surfactants. NECh-LUT showed a mean diameter of 67.5 nm, polydispersity index 0.174, zeta potential of +12.8 mV, and encapsulation efficiency of 85.49%. Transmission electron microscopy revealed spherical shape and rheological analysis verified the Newtonian behavior of NECh-LUT. SAXS technique confirmed the bimodal characteristic of NECh-LUT, while stability analysis confirmed NECh-LUT stability when stored at room temperature for up to 30 days. Finally, in vitro release studies showed LUT controlled release up to 72 h, indicating the promising potential of NECh-LUT to be used as novel therapeutic option to treat several disorders. Full article
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