Special Issue "Nitric Oxide Synthase: New Insights on Function, Regulation, NO Delivery & Therapeutics"
Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 250
Interests: nitric oxide biology and chemistry; nitric oxide synthase; flavoheme proteins; NO in cardiovascular disorders
Ever since its discovery in mammals as the producer of the inorganic signaling molecules, nitric oxide (NO), the enzyme nitric oxide synthase (NOS) has been the subject of extensive scientific research for the potential regulation of various life-sustaining and disease processes involving NO. Studies continue to uncover newer physiological and pathophysiological roles of NOS in mammals, as well as attempt to answer why this enzyme exists in three different isoforms with diverse catalytic activities in our body as neuronal NOS (nNOS) or NOS I, inducible NOS (iNOS) or NOS II, and endothelial NOS (eNOS) or NOS III. Emerging reports not only reveal novel roles for the three different isoforms of NOS in both physiological and disease processes, but also their unknown functions and mechanisms of in vivo regulation. These, in turn, pave for fresh strategies for the therapeutic control of NOS, especially for the clinical management of diseases associated with its dysfunctional expression.
This Special Issue aims to present recent advances in the study of the functions of NOS, its regulation, as well as therapeutic intervention in vivo. The Special Issue aims to publish manuscripts on molecular targets of NO, NO as a marker used for diagnostic purposes, the mechanism of action of NO, inhaled NO in the light of viral infections, the structure-function of NOS enzymes, and the chemistry and biology of NO and NOS enzymes. Both reviews and research manuscripts are welcome for updating our understanding of the precise role of this versatile enzyme in human physiology and diseases, therapeutics, delivery of NO, as well as strategies for its effective control, particularly in a clinical setting.
Prof. Dr. Mohammad Mahfuzul Haque
Prof. Dr. Koustubh Panda
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- nitric oxide synthase
- nitric oxide
- nitrosative stress
- protein nitration
- protein nitrosylation