Special Issue "Nitric Oxide Synthase: New Insights on Function, Regulation, NO Delivery & Therapeutics"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 250

Special Issue Editors

Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi 110025, India
Interests: nitric oxide biology and chemistry; nitric oxide synthase; flavoheme proteins; NO in cardiovascular disorders
Department of Biotechnology & Centre for Genetic Engineering & Biotechnology, University of Calcutta, Kolkata 700019, India
Interests: nitric oxide biology; nitric oxide synthase structure-function; oxido-nitrosative stress; inflammation & inflammatory diseases

Special Issue Information

Dear Colleagues,

Ever since its discovery in mammals as the producer of the inorganic signaling molecules, nitric oxide (NO), the enzyme nitric oxide synthase (NOS) has been the subject of extensive scientific research for the potential regulation of various life-sustaining and disease processes involving NO. Studies continue to uncover newer physiological and pathophysiological roles of NOS in mammals, as well as attempt to answer why this enzyme exists in three different isoforms with diverse catalytic activities in our body as neuronal NOS (nNOS) or NOS I, inducible NOS (iNOS) or NOS II, and endothelial NOS (eNOS) or NOS III. Emerging reports not only reveal novel roles for the three different isoforms of NOS in both physiological and disease processes, but also their unknown functions and mechanisms of in vivo regulation. These, in turn, pave for fresh strategies for the therapeutic control of NOS, especially for the clinical management of diseases associated with its dysfunctional expression.

This Special Issue aims to present recent advances in the study of the functions of NOS, its regulation, as well as therapeutic intervention in vivo. The Special Issue aims to publish manuscripts on molecular targets of NO, NO as a marker used for diagnostic purposes, the mechanism of action of NO, inhaled NO in the light of viral infections, the structure-function of NOS enzymes, and the chemistry and biology of NO and NOS enzymes. Both reviews and research manuscripts are welcome for updating our understanding of the precise role of this versatile enzyme in human physiology and diseases, therapeutics, delivery of NO, as well as strategies for its effective control, particularly in a clinical setting.

Prof. Dr. Mohammad Mahfuzul Haque
Prof. Dr. Koustubh Panda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nitric oxide synthase
  • NOS
  • nitric oxide
  • NO
  • iNOS
  • nNOS
  • eNOS
  • nitrosative stress
  • protein nitration
  • protein nitrosylation

Published Papers

There is no accepted submissions to this special issue at this moment.
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