Metal-Drug Complexes for Targeted Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 433

Special Issue Editor

Department of Chemistry, Faculty of Science, University of Cairo, Gamma street, Giza 12613, Egypt
Interests: metal-complex drug; inorganic chemistry; pharmaceutical chemistry

Special Issue Information

Dear Colleagues,

Recent research has revealed that carbon monoxide, the “silent killer” molecule, is an important signalling molecule in human physiology. As a result, efforts are being undertaken to deliver small amounts of CO to biological targets in an effort to produce advantageous effects. Several studies have demonstrated that CO produced endogenously and/or exogenously has beneficial anti-coagulative, anti-apoptotic, anti-inflammatory, and anti-proliferative properties as well as therapeutic benefits such as decreased organ graft rejection and defence against ischaemia reperfusion injury. The development of stable molecules that release CO only when prompted by an internal or external trigger is one approach to more regulated, targeted delivery. Carbon-monoxide-releasing molecules (CORMs) have the advantage of delivering potentially toxic levels of CO to certain organs and tissues without distributing CO to the entire body. The first-generation metal-based CORMs (CORM-1 and CORM-2) were a turning point for researchers who wanted to look into the possibility of using metal carbonyl complexes as prodrugs for CO delivery, and it encouraged them to continue with trials to make CO clinical applications a reality, using CORMs based on other metal ions and co-ligands.

With advancements in a variety of scientific fields, from synthetic/structural chemistry to biology, the varied architectures and properties of metal-based CORMs have become a very productive area of research. This Special Issue invites contributions in the most recent advances of metal-based CORM research, welcoming reviews and research articles on CORMs’ bio-inorganic chemistry, mechanistic insights, and applications in biological systems and medicine.

Dr. Ahmed M. Mansour
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photoCORM
  • metal carbonyls
  • therapeutic properties
  • antimicrobial properties
  • drug delivery

Published Papers

There is no accepted submissions to this special issue at this moment.
Back to TopTop