Special Issue "Novel Nanoparticle Formulations for Retinal Drug Delivery"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 August 2023 | Viewed by 971

Special Issue Editor

University Eye Hospital Tuebingen, Elfriede-Aulhorn - Str. 7, 72076 Tübingen, Germany
Interests: ophthalmology; neurodegeneration; neuroprotection; ex vivo retina cultures; drug delivery; retinal gene therapies; nanoparticle; small molecules therapies

Special Issue Information

Dear Colleagues,

The delivery of drugs intended to reach the retina is very complex. Nanocarriers, such as nanoparticles, can deliver ophthalmic drugs to specific targets and promise to revolutionise the treatment of many eye diseases. To date, the results strongly suggest that ophthalmology stands to benefit enormously from the use of this nanotechnology. In recent decades, nanotechnology appears to be creating new horizons for the treatment of ocular diseases by enabling the controlled release of drugs, ensuring fewer side effects, improving drug bioavailability, and forcing drug uptake into retinal cells. Numerous drug delivery systems have also been investigated regarding their ability to reach the posterior segment of the eye through topical application. The aim of this Special Issue is to provide an update on recent advancements in the synthesis, development and use of nanoparticles for drug delivery and sustained release in the retina, in view of the practical potential of nanoparticles and nanoformulations.

Dr. José Hurst
Guest Editor

Manuscript Submission Information

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Keywords

  • nano-based gene/drug delivery to target retinas/retinal explants/organoids 
  • targeted drug delivery to retinal cells 
  • neuroprotection 
  • formulation of nanoparticles for retinas 
  • organic and inorganic nanoparticles 
  • therapies for retinal diseases 
  • depot function of nanoparticles 
  • technologies for targeted delivery of DNA/RNA (ASO/nucleic acid) 
  • active transport/passive transport of nanoparticles

Published Papers (1 paper)

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Research

Article
A Multifunctional Hybrid Nanocarrier for Non-Invasive siRNA Delivery to the Retina
Pharmaceutics 2023, 15(2), 611; https://doi.org/10.3390/pharmaceutics15020611 - 11 Feb 2023
Viewed by 708
Abstract
Drug therapy for retinal diseases (e.g., age-related macular degeneration, the leading cause of blindness) is generally performed by invasive intravitreal injection because of poor drug delivery caused by the blood–retinal barrier (BRB). This study aimed to develop a nanocarrier for the non-invasive delivery [...] Read more.
Drug therapy for retinal diseases (e.g., age-related macular degeneration, the leading cause of blindness) is generally performed by invasive intravitreal injection because of poor drug delivery caused by the blood–retinal barrier (BRB). This study aimed to develop a nanocarrier for the non-invasive delivery of small interfering RNA (siRNA) to the posterior segment of the eye (i.e., the retina) by eyedrops. To this end, we prepared a hybrid nanocarrier based on a multifunctional peptide and liposomes, and the composition was optimized. A cytoplasm-responsive stearylated peptide (STR-CH2R4H2C) was used as the multifunctional peptide because of its superior ability to enhance the complexation, cell permeation, and intracellular dynamics of siRNA. By adding STR-CH2R4H2C to the surface of liposomes, intracellular uptake increased regardless of the liposome surface charge. The STR-CH2R4H2C-modified cationic nanocarrier demonstrated significant siRNA transfection efficiency with no cytotoxicity, enhanced siRNA release from endosomes, and effectively suppressed vascular endothelial growth factor expression in rat retinal pigment epithelium cells. The 2.0 mol% STR-CH2R4H2C-modified cationic nanocarrier enhanced intraocular migration into the retina after instillation into rat eyes. Full article
(This article belongs to the Special Issue Novel Nanoparticle Formulations for Retinal Drug Delivery)
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